2.3.1.140: rosmarinate synthase

This is an abbreviated version!
For detailed information about rosmarinate synthase, go to the full flat file.

Reaction

Synonyms

4-coumaroyl-CoA:4-hydroxyphenyllactic acid 4-coumaroyl transferase, 4-coumaroyl-CoA:hydroxyphenyllactic acid hydroxycinnamoyltransferase, AAT1, AT1, caffeoyl-coenzyme A:3,4-dihydroxyphenyllactic acid caffeoyltransferase, hydroxycinnamoyl-CoA:hydroxyphenyllactate hydroxycinnamoyltransferase, RAS, rosmarinic acid synthase

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.140 rosmarinate synthase

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Results	in table
1	Activating Compound
7	AA Sequence
2	Application
1	CAS Registry Number
4	Cloned(Commentary)
4	General Information
8	Inhibitors
1	Ki Value [mM]
60	KM Value [mM]
3	Localization
2	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
12	Organism
2	Oxidation Stability
3	Pathway
1	PDB ID
4	pH Optimum
1	pH Range
1	pH Stability
5	Purification (Commentary)
1	Reaction
1	Reaction Type
11	Reference
2	Source Tissue
1	Specific Activity [micromol/min/mg]
3	Storage Stability
70	Substrates and Products (Substrate)
2	Subunits
13	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
2	Temperature Stability [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.3.1.140 - rosmarinate synthase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

4-coumaroyl-CoA + 3-(3,4-dihydroxyphenyl)lactate

CoA + 2-O-(4-coumaroyl)-3-(3,4-dihydroxyphenyl)lactate

Melissa officinalis

-

-

720636

-

-

?

4-coumaroyl-CoA + 3-(4-hydroxyphenyl)lactate

CoA + 2-O-(4-coumaroyl)-3-(4-hydroxyphenyl)lactate

Melissa officinalis

-

-

720636

the precursor for rosmarinic acid synthesis via further hydroxylations, overview

-

?

caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)lactate

CoA + rosmarinate

2 entries

caffeoyl-CoA + 3-(4-hydroxyphenyl)lactate

CoA + 2-O-caffeoyl-3-(4-hydroxyphenyl)lactate

Melissa officinalis

-

-

720636

-

-

?

additional information

?

-

3 entries

caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)lactate

CoA + rosmarinate

Coleus scutellarioides

-

via intermediate 4-coumaroyl-4'-hydroxyphenyllactic acid

720787

-

-

?

caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)lactate

CoA + rosmarinate

Lavandula angustifolia

Q0GA14

-

720789

-

-

?

additional information

?

-

Coleus scutellarioides

-

probably 4-coumaroyl-CoA and 4-hydroxyphenyllactate are the substrates used in vivo

486319

-

-

?

additional information

?

-

Lavandula angustifolia

Q0GA14

recombinant LaAAT1 exhibits a broad substrate tolerance accepting (hydroxy)cinnamoyl-CoAs as acyl donors and not only tyramine, tryptamine, phenylethylamine, and anthranilic acid but also shikimic acid and 4-hydroxyphenyllactic acid as acceptors, showing substrate promiscuity

720789

-

-

?

additional information

?

-

Lavandula angustifolia

-

recombinant LaAAT1 exhibits a broad substrate tolerance accepting (hydroxy)cinnamoyl-CoAs as acyl donors and not only tyramine, tryptamine, phenylethylamine, and anthranilic acid but also shikimic acid and 4-hydroxyphenyllactic acid as acceptors, showing substrate promiscuity

720789

-

-

?