2.3.1.137: carnitine O-octanoyltransferase

This is an abbreviated version!
For detailed information about carnitine O-octanoyltransferase, go to the full flat file.

Reaction

Synonyms

carnitine acyltransferase, Carnitine medium-chain acyltransferase, carnitine octanoyltransferase, COT, CRAT, CrOT, easily solubilized mitochondrial carnitine palmitoyltransferase, medium-chain carnitine acyltransferase, medium-chain/long-chain carnitine acyltransferase, More, overt mitochondrial carnitine palmitoyltransferase, short-chain carnitine acyltransferase

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.137 carnitine O-octanoyltransferase

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Results	in table
1	Activating Compound
21	AA Sequence
1	CAS Registry Number
8	Cloned(Commentary)
1	Crystallization (Commentary)
42	Disease/ Diagnostics
1	General Information
2	General Stability
35	Inhibitors
5	Ki Value [mM]
63	KM Value [mM]
84	Localization
13	Molecular Weight [Da]
131	Natural Substrates/ Products (Substrates)
563	Organism
8	PDB ID
3	pH Optimum
2	pH Range
9	Protein Variants
14	Purification (Commentary)
4	Reaction
3	Reaction Type
64	Reference
75	Source Tissue
3	Specific Activity [micromol/min/mg]
6	Storage Stability
304	Substrates and Products (Substrate)
9	Subunits
46	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

Natural Substrates Products

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of the Enzyme Summary Page.

Natural Substrates Products on EC 2.3.1.137 - carnitine O-octanoyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

acetyl-CoA + L-carnitine

CoA + acetyl-carnitine

2 entries

acyl-CoA + L-carnitine

acyl-L-carnitine + CoA

20 entries

acyl-L-carnitine + CoA

acyl-CoA + L-carnitine

9 entries

L-carnitine + octanoyl-CoA

octanoyl-L-carnitine + CoA

7 entries

octanoyl-CoA + L-carnitine

CoA + L-octanoylcarnitine

5 entries

octanoyl-L-carnitine + CoA

L-carnitine + octanoyl-CoA

7 entries

propionyl-CoA + L-carnitine

CoA + propionyl-carnitine

2 entries

additional information

?

-

4 entries

acetyl-CoA + L-carnitine

CoA + acetyl-carnitine

Mus musculus

-

-

686028

-

-

?

acetyl-CoA + L-carnitine

CoA + acetyl-carnitine

Mus musculus 129/Sv

-

-

686028

-

-

?

acyl-CoA + L-carnitine

acyl-L-carnitine + CoA

Bos taurus

-

-

486290, 486291, 486294, 486295, 486297, 486303, 486304, 486305

-

-

r

acyl-CoA + L-carnitine

acyl-L-carnitine + CoA

Bos taurus

O19094

-

486305

-

-

r

acyl-CoA + L-carnitine

acyl-L-carnitine + CoA

Bos taurus

-

-

486306, 486307

-

-

r

acyl-CoA + L-carnitine

acyl-L-carnitine + CoA

Bos taurus

O19094

central role in fatty acid metabolism

486302

-

-

r

acyl-CoA + L-carnitine

acyl-L-carnitine + CoA

Canis lupus familiaris

-

-

486290, 486295

-

-

r

acyl-CoA + L-carnitine

acyl-L-carnitine + CoA

Columba sp.

-

-

486290, 486292

-

-

r

acyl-CoA + L-carnitine

acyl-L-carnitine + CoA

Homo sapiens

-

-

486290, 486298, 486304

-

-

r

acyl-CoA + L-carnitine

acyl-L-carnitine + CoA

Homo sapiens

Q9UKG9

-

486305

-

-

r

acyl-CoA + L-carnitine

acyl-L-carnitine + CoA

Meyerozyma guilliermondii

-

metabolic pathway of peroxisomal beta-oxidation in yeasts

486301

-

-

r

acyl-CoA + L-carnitine

acyl-L-carnitine + CoA

Mus musculus

-

-

486290, 486291, 486294, 486295, 486296, 486297, 486298

-

-

r

acyl-CoA + L-carnitine

acyl-L-carnitine + CoA

Mus musculus NMRI/Bom

-

-

486291

-

-

r

acyl-CoA + L-carnitine

acyl-L-carnitine + CoA

Oryctolagus cuniculus

-

-

486290

-

-

r

acyl-CoA + L-carnitine

acyl-L-carnitine + CoA

Platyrrhini

-

-

486290

-

-

r

acyl-CoA + L-carnitine

acyl-L-carnitine + CoA

Rattus norvegicus

-

-

486290, 486291, 486292, 486293, 486294, 486295, 486296, 486297, 486298, 486299, 486300, 486301, 486304, 486308

-

-

r

acyl-CoA + L-carnitine

acyl-L-carnitine + CoA

Rattus norvegicus

P11466

-

486305, 486307, 486310

-

-

r

acyl-CoA + L-carnitine

acyl-L-carnitine + CoA

Rattus norvegicus

-

beta-oxidation of fatty acids

486309

-

-

r

acyl-CoA + L-carnitine

acyl-L-carnitine + CoA

Rattus norvegicus Sprague-Dawley

-

-

486297, 486298, 486295

-

-

r

acyl-CoA + L-carnitine

acyl-L-carnitine + CoA

Rattus norvegicus Wistar

-

-

486296

-

-

r

acyl-CoA + L-carnitine

acyl-L-carnitine + CoA

Rattus norvegicus Wistar/Moell

-

-

486291

-

-

r

acyl-CoA + L-carnitine

acyl-L-carnitine + CoA

Sus scrofa

-

-

486290, 486292

-

-

r

acyl-L-carnitine + CoA

acyl-CoA + L-carnitine

Bos taurus

-

-

486295

-

-

r

acyl-L-carnitine + CoA

acyl-CoA + L-carnitine

Bos taurus

O19094

-

486302

-

-

r

acyl-L-carnitine + CoA

acyl-CoA + L-carnitine

Canis lupus familiaris

-

-

486295

-

-

r

acyl-L-carnitine + CoA

acyl-CoA + L-carnitine

Homo sapiens

-

-

486298

-

-

r

acyl-L-carnitine + CoA

acyl-CoA + L-carnitine

Meyerozyma guilliermondii

-

-

486301

-

-

r

acyl-L-carnitine + CoA

acyl-CoA + L-carnitine

Mus musculus

-

-

486295, 486296, 486298

-

-

r

acyl-L-carnitine + CoA

acyl-CoA + L-carnitine

Rattus norvegicus

-

-

486295, 486296, 486298, 486299, 486300, 486301

-

-

r

acyl-L-carnitine + CoA

acyl-CoA + L-carnitine

Rattus norvegicus Sprague-Dawley

-

-

486298, 486295

-

-

r

acyl-L-carnitine + CoA

acyl-CoA + L-carnitine

Rattus norvegicus Wistar

-

-

486296

-

-

r

L-carnitine + octanoyl-CoA

octanoyl-L-carnitine + CoA

Bos taurus

-

-

486290, 486291, 486294, 486295, 486297, 486305

-

-

r

L-carnitine + octanoyl-CoA

octanoyl-L-carnitine + CoA

Bos taurus

O19094

-

486305

-

-

r

L-carnitine + octanoyl-CoA

octanoyl-L-carnitine + CoA

Homo sapiens

-

-

486290

-

-

?

L-carnitine + octanoyl-CoA

octanoyl-L-carnitine + CoA

Mus musculus

-

-

486290, 486291, 486294, 486295, 486296, 486297

-

-

r

L-carnitine + octanoyl-CoA

octanoyl-L-carnitine + CoA

Rattus norvegicus

-

-

486290, 486291, 486292, 486293, 486294, 486295, 486296, 486297

-

-

r

L-carnitine + octanoyl-CoA

octanoyl-L-carnitine + CoA

Rattus norvegicus Sprague-Dawley

-

-

486295

-

-

r

L-carnitine + octanoyl-CoA

octanoyl-L-carnitine + CoA

Rattus norvegicus Wistar

-

-

486296

-

-

r

octanoyl-CoA + L-carnitine

CoA + L-octanoylcarnitine

Bos taurus

-

step in the transport of fatty acids across the inner mitochondrial membrane, reaction plays a role in balancing cellular CoA:acyl-CoA ratio

657546

-

-

r

octanoyl-CoA + L-carnitine

CoA + L-octanoylcarnitine

Mus musculus

-

-

686028

-

-

?

octanoyl-CoA + L-carnitine

CoA + L-octanoylcarnitine

Mus musculus

Q9DC50

-

659511

-

-

r

octanoyl-CoA + L-carnitine

CoA + L-octanoylcarnitine

Mus musculus 129/Sv

-

-

686028

-

-

?

octanoyl-CoA + L-carnitine

CoA + L-octanoylcarnitine

Rattus norvegicus

-

-

659306, 659372

-

-

?

octanoyl-L-carnitine + CoA

L-carnitine + octanoyl-CoA

Bos taurus

-

-

486290, 486291, 486294, 486295, 486297, 486305

-

-

r

octanoyl-L-carnitine + CoA

L-carnitine + octanoyl-CoA

Bos taurus

O19094

-

486305

-

-

r

octanoyl-L-carnitine + CoA

L-carnitine + octanoyl-CoA

Homo sapiens

-

-

486290

-

-

r

octanoyl-L-carnitine + CoA

L-carnitine + octanoyl-CoA

Mus musculus

-

-

486290, 486291, 486294, 486296, 486297

-

-

r

octanoyl-L-carnitine + CoA

L-carnitine + octanoyl-CoA

Mus musculus

-

reverse reaction

486295

-

-

r

octanoyl-L-carnitine + CoA

L-carnitine + octanoyl-CoA

Rattus norvegicus

-

-

486290, 486291, 486292, 486293, 486294, 486295, 486296, 486297

-

-

r

octanoyl-L-carnitine + CoA

L-carnitine + octanoyl-CoA

Rattus norvegicus Wistar

-

-

486296

-

-

r

propionyl-CoA + L-carnitine

CoA + propionyl-carnitine

Mus musculus

-

-

686028

-

-

?

propionyl-CoA + L-carnitine

CoA + propionyl-carnitine

Mus musculus 129/Sv

-

-

686028

-

-

?

additional information

?

-

Mus musculus

-

peroxisomal carnitine acyltransferases and acyl-CoA thioesterases are differently expressed to function as complementary enzymes for transport of beta-oxidation metabolites

686028

-

-

?

additional information

?

-

Mus musculus

-

peroxisomes contain carnitine acetyltransferase and octanoyltransferase that produce carnitine ester for transport out of the peroxisomes

686028

-

-

?

additional information

?

-

Mus musculus 129/Sv

-

peroxisomal carnitine acyltransferases and acyl-CoA thioesterases are differently expressed to function as complementary enzymes for transport of beta-oxidation metabolites

686028

-

-

?

additional information

?

-

Mus musculus 129/Sv

-

peroxisomes contain carnitine acetyltransferase and octanoyltransferase that produce carnitine ester for transport out of the peroxisomes

686028

-

-

?