2.3.1.129: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase
This is an abbreviated version!
For detailed information about acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase, go to the full flat file.
Word Map on EC 2.3.1.129
-
2.3.1.129
-
udp-glcnac
-
lipopolysaccharide
-
left-handed
-
acyl-acp
-
endotoxin
-
drug development
-
beta-helix
-
beta-helical
-
homotrimer
-
udp-3-o-r-3-hydroxymyristoyl-glcnac
-
raetz
-
medicine
- 2.3.1.129
- udp-glcnac
- lipopolysaccharide
-
left-handed
- acyl-acp
- endotoxin
- drug development
-
beta-helix
-
beta-helical
-
homotrimer
-
udp-3-o-r-3-hydroxymyristoyl-glcnac
-
raetz
- medicine
Reaction
Synonyms
acyltransferase, uridine diphosphoacetylglucosamine, LiLpxA, LpxA, type II ACP-dependent UDP-N-acetylglucosamine acyltransferase, type II acyl carrier protein-dependent UDP-N-acetylglucosamine acyltransferase, UDP-N-acetylglucosamine 3-O-acyltransferase, UDP-N-acetylglucosamine acyltransferase, uridine diphosphoacetylglucosamine acyltransferase
ECTree
2.3.1.129 acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferaseAdvanced search results
results (
results (Reference
top
Reference on EC 2.3.1.129 - acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Anderson, M.S.; Bulawa, C.E.; Raetz, C.R.
The biosynthesis of gram-negative endotoxin. Formation of lipid A precursors from UDP-GlcNAc in extracts of Escherichia coli
J. Biol. Chem.
260
15536-15541
1985
Escherichia coli, Escherichia coli JB1104
Anderson, M.S.; Raetz, C.R.
UDP-N-acetylglucosamine 3-O-acyltransferase from Escherichia coli
Methods Enzymol.
209
449-454
1992
Escherichia coli
Anderson, M.S.; Raetz, C.R.
Biosynthesis of lipid A precursors in Escherichia coli. A cytoplasmic acyltransferase that converts UDP-N-acetylglucosamine to UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine
J. Biol. Chem.
262
5159-5169
1987
Escherichia coli, Escherichia coli W3106, Escherichia coli JB1104
Anderson, M.S.; Bull, H.G.; Galloway, S.M.; Kelly, T.M.; Mohan, S.; Radika, K.; Raetz, C.R.
UDP-N-acetylglucosamine acyltransferase of Escherichia coli. The first step of endotoxin biosynthesis is thermodynamically unfavorable
J. Biol. Chem.
268
19858-19865
1993
Escherichia coli
Williamson, J.M.; Anderson, M.S.; Raetz, C.R.
Acyl-acyl carrier protein specificity of UDP-GlcNAc acyltransferases from gram-negative bacteria: relationship to lipid A structure
J. Bacteriol.
173
3591-3596
1991
Acinetobacter calcoaceticus, Klebsiella aerogenes, Citrobacter freundii, Escherichia coli, Klebsiella oxytoca, Proteus mirabilis, Pseudomonas aeruginosa, Cereibacter sphaeroides, Serratia marcescens, Escherichia coli SM105, Escherichia coli JB1104
Vaara, M.
Eight bacterial proteins, including UDP-N-acetylglucosamine acyltransferase (LpxA) and three other transferases of Escherichia coli, consist of a six-residue periodicity theme
FEMS Microbiol. Lett.
97
249-254
1992
Escherichia coli
-
Raetz, C.R.H.; Roderick, S.L.
A left-handed parallel beta helix in the structure of UDP-N-acetylglucosamine acyltransferase
Science
270
997-1000
1995
Escherichia coli
Sorensen, P.G.; Lutkenhaus, J.; Young, K.; Eveland, S.S.; Anderson, M.S.; Raetz, C.R.H.
Regulation of UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase in Escherichia coli. The second enzymic step of lipid A biosynthesis
J. Biol. Chem.
271
25898-25905
1996
Escherichia coli, Escherichia coli SM105
Wyckoff, T.J.O.; Raetz, C.R.H.
The active site of Escherichia coli UDP-N-acetylglucosamine acyltransferase. Chemical modification and site-directed mutagenesis
J. Biol. Chem.
274
27047-27055
1999
Escherichia coli
Odegaard, T.J.; Kaltashov, I.A.; Cotter, R.J.; Steeghs, L.; Van Der Ley, P.; Khan, S.; Maskell, D.J.; Raetz, C.R.H.
Shortened hydroxyacyl chains on lipid A of Escherichia coli cells expressing a foreign UDP-N-acetylglucosamine O-acyltransferase
J. Biol. Chem.
272
19688-19696
1997
Escherichia coli, Neisseria meningitidis
Wyckoff, T.J.O.; Lin, S.; Cotter, R.J.; Dotson, G.D.; Raetz, C.R.H.
Hydrocarbon rulers in UDP-N-acetylglucosamine acyltransferases
J. Biol. Chem.
273
32369-32372
1998
Escherichia coli, Pseudomonas aeruginosa
Dotson, G.D.; Kaltashov, I.A.; Cotter, R.J.; Raetz, C.R.H.
Expression cloning of a Pseudomonas gene encoding a hydroxydecanoyl-acyl carrier protein-dependent UDP-GlcNAc acyltransferase
J. Bacteriol.
180
330-337
1998
Pseudomonas aeruginosa
Sweet, C.R.; Preston, A.; Toland, E.; Ramirez, S.M.; Cotter, R.J.; Maskell, D.J.; Raetz, C.R.H.
Relaxed acyl chain specificity of Bordetella UDP-N-acetylglucosamine acyltransferases
J. Biol. Chem.
277
18281-18290
2002
Bordetella bronchiseptica, Bordetella parapertussis, Bordetella pertussis
Sweet, C.R.; Lin, S.; Cotter, R.J.; Raetz, C.R.H.
A Chlamydia trachomatis UDP-N-acetylglucosamine acyltransferase selective for myristoyl-acyl carrier protein. Expression in Escherichia coli and formation of hybrid lipid A species
J. Biol. Chem.
276
19565-19574
2001
Chlamydia trachomatis
Lee, B.I.; Lee, J.Y.; Moon, J.; Han, B.W.; Suh, S.W.
Crystallization and preliminary x-ray crystallographic analysis of UDP-N-acetylglucosamine acyltransferase from Helicobacter pylori
Acta Crystallogr. Sect. D
58
864-866
2002
Helicobacter pylori
Sweet, C.R.; Williams, A.H.; Karbarz, M.J.; Werts, C.; Kalb, S.R.; Cotter, R.J.; Raetz, C.R.
Enzymatic synthesis of lipid A molecules with four amide-linked acyl chains. LpxA acyltransferases selective for an analog of UDP-N-acetylglucosamine in which an amine replaces the 3"-hydroxyl group
J. Biol. Chem.
279
25411-25419
2004
Escherichia coli, Leptospira interrogans, Mesorhizobium loti, Acidithiobacillus ferrooxidans (Q6QHI7)
Lee, B.I.; Suh, S.W.
Crystal structure of UDP-N-acetylglucosamine acyltransferase from Helicobacter pylori
Proteins
53
772-774
2003
Helicobacter pylori
Peng, D.; Hong, W.; Choudhury, B.P.; Carlson, R.W.; Gu, X.X.
Moraxella catarrhalis bacterium without endotoxin, a potential vaccine candidate
Infect. Immun.
73
7569-7577
2005
Moraxella catarrhalis (Q3BDJ0), Moraxella catarrhalis, Moraxella catarrhalis O35E (Q3BDJ0)
Gong, H.; Murphy, A.; McMaster, C.R.; Byers, D.M.
Neutralization of acidic residues in helix II stabilizes the folded conformation of acyl carrier protein and variably alters its function with different enzymes
J. Biol. Chem.
282
4494-4503
2007
Vibrio harveyi
Ulaganathan, V.; Buetow, L.; Hunter, W.N.
Nucleotide substrate recognition by UDP-N-acetylglucosamine acyltransferase (LpxA) in the first step of lipid A biosynthesis
J. Mol. Biol.
369
305-312
2007
Escherichia coli (P0A722), Escherichia coli
Williams, A.H.; Immormino, R.M.; Gewirth, D.T.; Raetz, C.R.
Structure of UDP-N-acetylglucosamine acyltransferase with a bound antibacterial pentadecapeptide
Proc. Natl. Acad. Sci. USA
103
10877-10882
2006
Escherichia coli (P0A722), Escherichia coli
Williams, A.H.; Raetz, C.R.
Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine acyltransferase
Proc. Natl. Acad. Sci. USA
104
13543-13550
2007
Escherichia coli (P0A722), Escherichia coli
Gong, H.; Murphy, P.W.; Langille, G.M.; Minielly, S.J.; Murphy, A.; McMaster, C.R.; Byers, D.M.
Tryptophan fluorescence reveals induced folding of Vibrio harveyi acyl carrier protein upon interaction with partner enzymes
Biochim. Biophys. Acta
1784
1835-1843
2008
Escherichia coli
Robins, L.I.; Williams, A.H.; Raetz, C.R.
Structural basis for the sugar nucleotide and acyl-chain selectivity of Leptospira interrogans LpxA
Biochemistry
48
6191-6201
2009
Leptospira interrogans (Q8EZA6), Leptospira interrogans
Choi, J.H.; May, B.C.; Govaerts, C.; Cohen, F.E.
Site-directed mutagenesis demonstrates the plasticity of the beta helix: implications for the structure of the misfolded prion protein
Structure
17
1014-1023
2009
Escherichia coli (P0A722), Escherichia coli
Jenkins, R.J.; Dotson, G.D.
Dual targeting antibacterial peptide inhibitor of early lipid a biosynthesis
ACS Chem. Biol.
7
1170-1177
2012
Escherichia coli
Jenkins, R.J.; Dotson, G.D.
A continuous fluorescent enzyme assay for early steps of lipid A biosynthesis
Anal. Biochem.
425
21-27
2012
Escherichia coli
Joo, S.H.; Chung, H.S.; Raetz, C.R.; Garrett, T.A.
Activity and crystal structure of Arabidopsis thaliana UDP-N-acetylglucosamine acyltransferase
Biochemistry
51
4322-4330
2012
Arabidopsis thaliana (Q9SU91), Arabidopsis thaliana
Das, A.; Mukhopadhyay, C.
LpxA: a natural nanotube
Biopolymers
93
845-853
2010
Escherichia coli
Shapiro, A.B.; Ross, P.L.; Gao, N.; Livchak, S.; Kern, G.; Yang, W.; Andrews, B.; Thresher, J.
A high-throughput-compatible fluorescence anisotropy-based assay for competitive inhibitors of Escherichia coli UDP-N-acetylglucosamine acyltransferase (LpxA)
J. Biomol. Screen.
18
341-347
2013
Escherichia coli
Li, C.; Guan, Z.; Liu, D.; Raetz, C.R.
Pathway for lipid A biosynthesis in Arabidopsis thaliana resembling that of Escherichia coli
Proc. Natl. Acad. Sci. USA
108
11387-11392
2011
Arabidopsis thaliana (Q9SU91)
Ngo, A.; Fong, K.T.; Cox, D.L.; Chen, X.; Fisher, A.J.
Structures of Bacteroides fragilis uridine 5-diphosphate-N-acetylglucosamine (UDP-GlcNAc) acyltransferase (BfLpxA)
Acta Crystallogr. Sect. D
71
1068-1076
2015
Bacteroides fragilis (Q5LH16), Bacteroides fragilis DSM 2151 (Q5LH16)
Smith, E.W.; Zhang, X.; Behzadi, C.; Andrews, L.D.; Cohen, F.; Chen, Y.
Structures of Pseudomonas aeruginosa LpxA reveal the basis for its substrate selectivity
Biochemistry
54
5937-5948
2015
Pseudomonas aeruginosa (A6V1E4), Pseudomonas aeruginosa, Pseudomonas aeruginosa PA7 (A6V1E4)
Jenkins, R.J.; Heslip, K.A.; Meagher, J.L.; Stuckey, J.A.; Dotson, G.D.
Structural basis for the recognition of peptide RJPXD33 by acyltransferases in lipid A biosynthesis
J. Biol. Chem.
289
15527-15535
2014
Escherichia coli (P0A722), Escherichia coli
Joo, S.H.; Chung, H.S.
Crystal structure and activity of Francisella novicida UDP-N-acetylglucosamine acyltransferase
Biochem. Biophys. Res. Commun.
478
1223-1229
2016
Francisella tularensis subsp. novicida
Bhaskar, B.; Babu, T.; Rammohan, A.; Zheng, G.; Zyryanov, G.; Gu, W.
Structure-based virtual screening of Pseudomonas aeruginosa Lpxa inhibitors using pharmacophore-based approach
Biomolecules
10
266
2020
Pseudomonas aeruginosa (A6V1E4), Pseudomonas aeruginosa PA7 (A6V1E4)
Pratap, S.; Kesari, P.; Yadav, R.; Dev, A.; Narwal, M.; Kumar, P.
Acyl chain preference and inhibitor identification of Moraxella catarrhalis LpxA Insight through crystal structure and computational studies
Int. J. Biol. Macromol.
96
759-765
2017
Moraxella catarrhalis (D5VAW8), Moraxella catarrhalis, Moraxella catarrhalis BBH18 (D5VAW8)
Kim, S.; Yoon, H.; Ryu, S.
New virulence factor CSK29544_02616 as LpxA binding partner in Cronobacter sakazakii
Sci. Rep.
8
835
2018
Cronobacter sakazakii
html completed
