2.3.1.122: trehalose O-mycolyltransferase
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For detailed information about trehalose O-mycolyltransferase, go to the full flat file.
Word Map on EC 2.3.1.122
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2.3.1.122
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tuberculosis
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mycobacterium
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bovis
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esat-6
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antigen-specific
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ifn-gamma
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bacille
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ankara
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prime-boost
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mva85a
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immunodominant
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mycolylation
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bcg-vaccinated
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mycolic
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tuberculin
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booster
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polyfunctional
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aerosol
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bcg-primed
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calmette-guerin
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elispot
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drug development
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th1-type
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fibronectin-binding
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bcg-induced
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medicine
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tuberculosis-infected
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biotechnology
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dimycolate
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post-vaccination
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ifn-gamma-producing
- 2.3.1.122
- tuberculosis
- mycobacterium
- bovis
-
esat-6
-
antigen-specific
- ifn-gamma
-
bacille
- ankara
-
prime-boost
-
mva85a
-
immunodominant
-
mycolylation
-
bcg-vaccinated
-
mycolic
-
tuberculin
-
booster
-
polyfunctional
-
aerosol
-
bcg-primed
- calmette-guerin
-
elispot
- drug development
-
th1-type
-
fibronectin-binding
-
bcg-induced
- medicine
-
tuberculosis-infected
- biotechnology
-
dimycolate
-
post-vaccination
-
ifn-gamma-producing
Reaction
2 alpha,alpha-trehalose 6-mycolate
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Synonyms
Ag85A, ag85C, alpha,alpha'-trehalose 6-monomycolate:alpha,alpha'-trehalose mycolyltransferase, antigen 85A, antigen 85C, cg0413, CMT1, corynomycoloyl transferase C, FbpA mycolyltransferase, mycoloyl transferase, mycolyl-transferase Ag85A, mycolyltransferase, mycolyltransferase, trehalose 6-monomycolate-trehalose, MytC
ECTree
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Application on EC 2.3.1.122 - trehalose O-mycolyltransferase
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APPLICATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
biotechnology
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an enzyme assay using the natural substrate trehalose dimycolate is developed. The colorimetric assay is based on the quantification of glucose from the degradation of trehalose, which is the product from catalytic activity of antigen 85A. This assay is suitable for robust high-throughput screening (HTS) for compound library screening against mycolyltransferase. The assay has a very low coefficient of variance (0.04) in 96-well plates and shows a Z' factor of 0.67-0.73, indicating the robustness of the assay
medicine
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the enzyme is immunogenic in C57BL/6 mice and effective as tuberculosis vaccine, usage of vaccines combining mycolyl-transferase Ag85A and phosphate transport receptor PstS-3, overview
