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2.3.1.118: N-hydroxyarylamine O-acetyltransferase

This is an abbreviated version!
For detailed information about N-hydroxyarylamine O-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.118

Reaction

acetyl-CoA
+
an N-hydroxyarylamine
=
CoA
 +
an N-acetoxyarylamine

Synonyms

acetyltransferase, N-hydroxyarylamine O-, arylamine N-acetyltransferase, arylhydroxamate N,O-acetyltransferase, N-arylamine acetyltransferase, N-hydroxy-2-aminofluorene-O-acetyltransferase, N-hydroxyarylamine O-acetyltransferase, NhoA, NhoA1, NhoA2

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.118 N-hydroxyarylamine O-acetyltransferase

Engineering

Engineering on EC 2.3.1.118 - N-hydroxyarylamine O-acetyltransferase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C69A
-
mutation in isoform NhoA1, inactive
C72A
-
mutation in isoform NhoA2, inactive
R65A
-
mutation if isoform NhoA1, inactive
R68A
-
mutation in isoform NhoA2, inactive
G127A
-
mutation has no obvious effect on enzymatic activity
K214R
-
the mutant exhibits an about 25% decrease in enzyme activity compared to the wild type enzyme
K214R/K281R
-
the mutant exhibits an about 25% decrease in enzyme activity compared to the wild type enzyme
K281R
-
the mutant exhibits an about 12% decrease in enzyme activity compared to the wild type enzyme
G127A
-
mutation has no obvious effect on enzymatic activity
-
K214R
-
the mutant exhibits an about 25% decrease in enzyme activity compared to the wild type enzyme
-
K214R/K281R
-
the mutant exhibits an about 25% decrease in enzyme activity compared to the wild type enzyme
-
K281R
-
the mutant exhibits an about 12% decrease in enzyme activity compared to the wild type enzyme
-
I238T
-
about 30% of wild-type activity
K185N
-
about 40% of wild-type activity
N172I
-
about 20% of wild-type activity
N245I
-
enzymic activity comparable to wild-type, slight increase in Km-value
W77R
-
about 25% of wild-type activity
A69C
-
reduces enzyme activity without affecting stability and mobility on SDS-PAGE
A69R
-
reduces enzyme activity without affecting stability and mobility on SDS-PAGE
A69C
-
reduces enzyme activity without affecting stability and mobility on SDS-PAGE
-
A69R
-
reduces enzyme activity without affecting stability and mobility on SDS-PAGE
-
A69C
-
reduces enzyme activity without affecting stability and mobility on SDS-PAGE
-
A69R
-
reduces enzyme activity without affecting stability and mobility on SDS-PAGE
-