2.3.1.117: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
This is an abbreviated version!
For detailed information about 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, go to the full flat file.
Word Map on EC 2.3.1.117
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2.3.1.117
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l-lysine
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meso-diaminopimelate
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diaminopimelate
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trimer
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glutamicum
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left-handed
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peptidoglycan
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corynebacterium
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beta-helix
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tuberculosis
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desuccinylase
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succinylated
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hexapeptide
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dihydrodipicolinate
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lbetah
- 2.3.1.117
- l-lysine
- meso-diaminopimelate
- diaminopimelate
- trimer
- glutamicum
-
left-handed
- peptidoglycan
- corynebacterium
-
beta-helix
- tuberculosis
-
desuccinylase
-
succinylated
- hexapeptide
- dihydrodipicolinate
-
lbetah
Reaction
Synonyms
DapD, Mtb-DapD, PA3666, succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase, succinyltransferase, tetrahydrodipicolinate, TabB, tetrahydrodipicolinate N-succinyltransferase, tetrahydrodipicolinate succinylase, tetrahydrodipicolinate succinyltransferase, tetrahydrodipicolinate-N-succinyltransferase, THDP
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Substrates Products
Substrates Products on EC 2.3.1.117 - 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
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REACTION DIAGRAM
succinyl-CoA + (2S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylic acid
CoA + (2S)-2-[(3-carboxypropanoyl)amino]-6-oxoheptanedioic acid
succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O
CoA + N-succinyl-L-2-amino-6-oxoheptanedioate
succinyl-CoA + 3,4-dihydro-2H-1,4-thiazine-3,5-dicarboxylic acid
?
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?
succinyl-CoA + 6-amino-2-hydroxypimelic acid
CoA + N-succinyl-6-amino-2-hydroxypimelate
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-
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?
succinyl-CoA + L-6-amino-L-2-hydroxypimelic acid
CoA + N-succinyl-L-6-amino-L-2-hydroxypimelate
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mixture of isomers
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?
succinyl-CoA + tetrahydrodipicolinate
CoA + (2S)-2-(3-carboxypropanamido)-6-oxoheptanedioate
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-
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?
CoA + (2S)-2-[(3-carboxypropanoyl)amino]-6-oxoheptanedioic acid
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-
-
?
succinyl-CoA + (2S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylic acid
CoA + (2S)-2-[(3-carboxypropanoyl)amino]-6-oxoheptanedioic acid
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involved in the four-step succinylase branch of the L-lysine biosynthetic pathway
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?
succinyl-CoA + (2S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylic acid
CoA + (2S)-2-[(3-carboxypropanoyl)amino]-6-oxoheptanedioic acid
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-
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?
succinyl-CoA + (2S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylic acid
CoA + (2S)-2-[(3-carboxypropanoyl)amino]-6-oxoheptanedioic acid
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product formation is strongly preferred
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r
succinyl-CoA + (2S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylic acid
CoA + (2S)-2-[(3-carboxypropanoyl)amino]-6-oxoheptanedioic acid
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involved in the biosynthesis of lysine in bacteria, blue-green algae and higher plants
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?
succinyl-CoA + (2S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylic acid
CoA + (2S)-2-[(3-carboxypropanoyl)amino]-6-oxoheptanedioic acid
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involved in the biosynthesis of lysine in bacteria, blue-green algae and higher plants
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r
succinyl-CoA + (2S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylic acid
CoA + (2S)-2-[(3-carboxypropanoyl)amino]-6-oxoheptanedioic acid
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-
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?
succinyl-CoA + (2S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylic acid
CoA + (2S)-2-[(3-carboxypropanoyl)amino]-6-oxoheptanedioic acid
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-
-
?
succinyl-CoA + (2S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylic acid
CoA + (2S)-2-[(3-carboxypropanoyl)amino]-6-oxoheptanedioic acid
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involved in the biosynthesis of lysine in bacteria, blue-green algae and higher plants
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?
CoA + N-succinyl-L-2-amino-6-oxoheptanedioate
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the enzyme is absolutely specific for the L-2-aminopimelate enantiomer
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-
?
succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O
CoA + N-succinyl-L-2-amino-6-oxoheptanedioate
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the enzyme is absolutely specific for the L-2-aminopimelate enantiomer, L-2-aminopimelate and weak inhibitor D-2-aminopimelate bind at the same site of the enzyme. Binding interaction analysis of the ligands in the enzyme active site suggests a misalignment of the amino group of D-2-aminopimelate for nucleophilic attack on the succinate moiety of the co-substrate succinyl-CoA as the structural basis of specificity and inhibition
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?
CoA + N-succinyl-L-aminopimelate
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-
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?
succinyl-CoA + L-2-aminopimelate
CoA + N-succinyl-L-aminopimelate
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tetrahydrodipicolinate analogue
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?
?
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no activity ith L-lysine, adipic acid, alpha-amino-adipic acid, L-epsilon-acetyl-lysine, L-glutamate, L-glutamine, L-norleucine, substrate specificity for DapD, overview. Binding of CoA to PaDapD does not induce any large conformational changes, ternary complex structure of DapD with bound CoA and succinate, overview
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additional information
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no substrates: 5,5'-dithio-bis-(2-nitrobenzoic acid), L-aminoadipic acid, poor substrate: acetyl-CoA
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