2.3.1.108: alpha-tubulin N-acetyltransferase

This is an abbreviated version!
For detailed information about alpha-tubulin N-acetyltransferase, go to the full flat file.

Reaction

Synonyms

acetyl-CoA:alpha-tubulin-L-lysine Ne-acetyltransferase, alpha-TAT, alpha-tubulin acetylase, alpha-tubulin acetyltransferase, alpha-tubulin K40 acetyltransferase, alpha-tubulin N-acetyltransferase 1, alphaTAT, alphaTAT1, alphaTAT2, ATAT-2, ATAT1, ATAT1 acetylase, ATAT1 tubulin acetyltransferase, elongator, KAT, lysine acetyltransferase, Mec-17, TAT, tubulin acetyltransferase

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.108 alpha-tubulin N-acetyltransferase

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Results	in table
1	Activating Compound
1631	AA Sequence
1	CAS Registry Number
9	Cloned(Commentary)
11	Cofactor
3	Crystallization (Commentary)
303	Disease/ Diagnostics
1	Expression
47	General Information
5	Inhibitors
20	kcat/KM [mM/s]
1	Ki Value [mM]
22	KM Value [mM]
22	Localization
6	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
40	Organism
18	PDB ID
5	pH Optimum
2	Posttranslational Modification
44	Protein Variants
3	Purification (Commentary)
1	Reaction
1	Reaction Type
39	Reference
36	Source Tissue
42	Substrates and Products (Substrate)
3	Subunits
53	Synonyms
1	Systematic Name
20	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.3.1.108 - alpha-tubulin N-acetyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

acetyl-CoA + alpha-tubulin L-lysine

CoA + alpha-tubulin N6-acetyl-L-lysine

13 entries

acetyl-CoA + cortactin

CoA + N-acetyl-cortactin

2 entries

acetyl-CoA + [alpha-TAT1]-L-lysine

CoA + [alpha-TAT1]-N6-acetyl-L-lysine

Mus musculus

Q8K341

-

736795

enzyme TAT1 acetylates itself in a regulatory mechanism that is required for effective modification of tubulin. Acetylation of multiple lysine residues on itself

-

?

acetyl-CoA + [alpha-tubulin]-L-lysine

CoA + [alpha-tubulin]-N6-acetyl-L-lysine

12 entries

acetyl-CoA + [alpha-tubulin]-L-lysine40

CoA + [alpha-tubulin]-N6-acetyl-L-lysine40

3 entries

additional information

?

-

8 entries

acetyl-CoA + alpha-tubulin L-lysine

CoA + alpha-tubulin N6-acetyl-L-lysine

Bos taurus

-

-

486115

-

486115

?

acetyl-CoA + alpha-tubulin L-lysine

CoA + alpha-tubulin N6-acetyl-L-lysine

Bos taurus

-

-

486116

-

-

?

acetyl-CoA + alpha-tubulin L-lysine

CoA + alpha-tubulin N6-acetyl-L-lysine

Bos taurus

-

acetylation of the lysine residue at position 40

486116

-

486116

?

acetyl-CoA + alpha-tubulin L-lysine

CoA + alpha-tubulin N6-acetyl-L-lysine

Bos taurus

-

alpha-tubulin from calf is acetylated

486116

-

486116

?

acetyl-CoA + alpha-tubulin L-lysine

CoA + alpha-tubulin N6-acetyl-L-lysine

Chlamydomonas reinhardtii

-

alpha-tubulin from mouse is acetylated

486115

-

486115

?

acetyl-CoA + alpha-tubulin L-lysine

CoA + alpha-tubulin N6-acetyl-L-lysine

Chlamydomonas reinhardtii

-

alpha-tubulin from calf is acetylated

486118

-

-

?

acetyl-CoA + alpha-tubulin L-lysine

CoA + alpha-tubulin N6-acetyl-L-lysine

Chlamydomonas reinhardtii

-

alpha-tubulin from Chlamydomonas is acetylated

486115

-

486115

?

acetyl-CoA + alpha-tubulin L-lysine

CoA + alpha-tubulin N6-acetyl-L-lysine

Chlamydomonas reinhardtii

-

alpha-tubulin from Chlamydomonas is acetylated

486117, 486118

-

-

?

acetyl-CoA + alpha-tubulin L-lysine

CoA + alpha-tubulin N6-acetyl-L-lysine

Chlamydomonas reinhardtii

-

post-translational modification of alpha-tubulin

486115

-

-

?

acetyl-CoA + alpha-tubulin L-lysine

CoA + alpha-tubulin N6-acetyl-L-lysine

Chlamydomonas reinhardtii 21 gr

-

alpha-tubulin from calf is acetylated

486118

-

-

?

acetyl-CoA + alpha-tubulin L-lysine

CoA + alpha-tubulin N6-acetyl-L-lysine

Chlamydomonas reinhardtii 21 gr

-

alpha-tubulin from Chlamydomonas is acetylated

486118

-

-

?

acetyl-CoA + alpha-tubulin L-lysine

CoA + alpha-tubulin N6-acetyl-L-lysine

Homo sapiens

Q5SQI0

-

736637

-

-

?

acetyl-CoA + alpha-tubulin L-lysine

CoA + alpha-tubulin N6-acetyl-L-lysine

Homo sapiens

Q5SQI0

-

735638

alpha-tubulin residue Ser38 is crucial for substrate recognition,whereas Asp39, Ile42, the glycine stretch (amino acid residues 43–45) and Asp46 are also involved

-

?

acetyl-CoA + cortactin

CoA + N-acetyl-cortactin

Homo sapiens

-

-

719403

-

-

?

acetyl-CoA + cortactin

CoA + N-acetyl-cortactin

Homo sapiens

-

ATAT1 acetylates, binds and colocalizes with cortactin at the adherent surface of MDA-MB-231 cells

719403

-

-

?

acetyl-CoA + [alpha-tubulin]-L-lysine

CoA + [alpha-tubulin]-N6-acetyl-L-lysine

Caenorhabditis elegans

-

-

719320, 720906

-

-

?

acetyl-CoA + [alpha-tubulin]-L-lysine

CoA + [alpha-tubulin]-N6-acetyl-L-lysine

Caenorhabditis elegans

-

acetylation of the epsilon-amino group of Lys40

720540

-

-

?

acetyl-CoA + [alpha-tubulin]-L-lysine

CoA + [alpha-tubulin]-N6-acetyl-L-lysine

Caenorhabditis elegans

-

K40 of alpha-tubulin is the sole site of acetylation by alphaTAT1, alphaTAT1 specifically acetylates K40 of alpha-tubulin and prefers microtubules over free tubulin, overview

720907

-

-

?

acetyl-CoA + [alpha-tubulin]-L-lysine

CoA + [alpha-tubulin]-N6-acetyl-L-lysine

Caenorhabditis elegans

-

alphaTAT1 acetylates tubulin through its GNAT domain in vitro. K40 of alpha-tubulin is the sole site of acetylation by alphaTAT1. alphaTAT1 displays a greater catalytic efficiency for taxol-stabilized microtubules than for free tubulin

720907

-

-

?

acetyl-CoA + [alpha-tubulin]-L-lysine

CoA + [alpha-tubulin]-N6-acetyl-L-lysine

Chlamydomonas reinhardtii

-

acetylation of the epsilon-amino group of Lys40

720540

-

-

?

acetyl-CoA + [alpha-tubulin]-L-lysine

CoA + [alpha-tubulin]-N6-acetyl-L-lysine

Danio rerio

-

acetylation of the epsilon-amino group of Lys40

720540

-

-

?

acetyl-CoA + [alpha-tubulin]-L-lysine

CoA + [alpha-tubulin]-N6-acetyl-L-lysine

Homo sapiens

-

-

719403, 720906

-

-

?

acetyl-CoA + [alpha-tubulin]-L-lysine

CoA + [alpha-tubulin]-N6-acetyl-L-lysine

Homo sapiens

-

acetylation of alpha-tubulin mostly occurs on lysine residue 40, which is localized in the microtubule lumen

719403

-

-

?

acetyl-CoA + [alpha-tubulin]-L-lysine

CoA + [alpha-tubulin]-N6-acetyl-L-lysine

Mus musculus

-

acetylation of the epsilon-amino group of Lys40

720540

-

-

?

acetyl-CoA + [alpha-tubulin]-L-lysine

CoA + [alpha-tubulin]-N6-acetyl-L-lysine

Tetrahymena sp.

-

-

720906

-

-

?

acetyl-CoA + [alpha-tubulin]-L-lysine

CoA + [alpha-tubulin]-N6-acetyl-L-lysine

Tetrahymena thermophila

-

acetylation of the epsilon-amino group of Lys40

720540

-

-

?

acetyl-CoA + [alpha-tubulin]-L-lysine

CoA + [alpha-tubulin]-N6-acetyl-L-lysine

Tetrahymena thermophila

-

acetylation of the epsilon-amino group of Lys40, in Tetrahymena, alpha-tubulin is the major if not the only substrate of MEC-17-dependent K acetylation

720540

-

-

?

acetyl-CoA + [alpha-tubulin]-L-lysine40

CoA + [alpha-tubulin]-N6-acetyl-L-lysine40

Chlorocebus aethiops

-

-

755997

-

-

?

acetyl-CoA + [alpha-tubulin]-L-lysine40

CoA + [alpha-tubulin]-N6-acetyl-L-lysine40

Homo sapiens

Q5SQI0

-

756850

-

-

?

acetyl-CoA + [alpha-tubulin]-L-lysine40

CoA + [alpha-tubulin]-N6-acetyl-L-lysine40

Mus musculus

Q8K341

-

736795

-

-

?

additional information

?

-

Caenorhabditis elegans

-

alphaTAT/MEC-17 is a lysine acetyltransferase for tubulin and not histones

720906

-

-

?

additional information

?

-

Caenorhabditis elegans

-

wild-type adults have a strong signal for acetylated alpha-tubulin in the six touch receptor neurons

720540

-

-

?

additional information

?

-

Caenorhabditis elegans

-

in vitro, MEC-17 exclusively acetylates Lys40 of alpha-tubulin

720540

-

-

?

additional information

?

-

Homo sapiens

-

alphaTAT/MEC-17 is a lysine acetyltransferase for tubulin and not histones

720906

-

-

?

additional information

?

-

Homo sapiens

Q5SQI0

the enzyme shows tubulin-specific acetylation activity

756850

-

-

-

additional information

?

-

Homo sapiens

-

the enzyme shows tubulin-specific acetylation activity

756850

-

-

-

additional information

?

-

Mus musculus

-

recombinant GST-MEC-17 directly acetylates purified tubulin from the MEC17-KO strain in vitro

720540

-

-

?

additional information

?

-

Tetrahymena sp.

-

alphaTAT/MEC-17 is a lysine acetyltransferase for tubulin and not histones

720906

-

-

?