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2.3.1.108: alpha-tubulin N-acetyltransferase

This is an abbreviated version!
For detailed information about alpha-tubulin N-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.108

Reaction

acetyl-CoA
+
[alpha-tubulin]-L-lysine
=
CoA
+
[alpha-tubulin]-N6-acetyl-L-lysine

Synonyms

acetyl-CoA:alpha-tubulin-L-lysine Ne-acetyltransferase, alpha-TAT, alpha-tubulin acetylase, alpha-tubulin acetyltransferase, alpha-tubulin K40 acetyltransferase, alpha-tubulin N-acetyltransferase 1, alphaTAT, alphaTAT1, alphaTAT2, ATAT-2, ATAT1, ATAT1 acetylase, ATAT1 tubulin acetyltransferase, elongator, KAT, lysine acetyltransferase, Mec-17, TAT, tubulin acetyltransferase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.108 alpha-tubulin N-acetyltransferase

Reference

Reference on EC 2.3.1.108 - alpha-tubulin N-acetyltransferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
MacRae, T.H.
Tubulin post-translational modifications
Eur. J. Biochem.
244
265-278
1997
Bos taurus, Chlamydomonas reinhardtii
Manually annotated by BRENDA team
Lloyd, R.A.; Gentleman, S.; Chader, G.J.
Assay of tubulin acetyltransferase activity in subcellular tissue fractions
Anal. Biochem.
216
42-46
1994
Bos taurus
Manually annotated by BRENDA team
Maruta, H.; Greer, K.; Rosenbaum, J.L.
The acetylation of alpha-tubulin and its relationship to the assembly and disassembly of microtubules
J. Cell Biol.
103
571-579
1986
Chlamydomonas reinhardtii
Manually annotated by BRENDA team
Greer, K.; Maruta, H.; L'Hernault, S.W.; Rosenbaum, J.L.
Alpha-tubulin acetylase activity in isolated Chlamydomonas flagella
J. Cell Biol.
101
2081-2084
1985
Chlamydomonas reinhardtii, Chlamydomonas reinhardtii 21 gr
Manually annotated by BRENDA team
Solinger, J.A.; Paolinelli, R.; Kloess, H.; Scorza, F.B.; Marchesi, S.; Sauder, U.; Mitsushima, D.; Capuani, F.; Stuerzenbaum, S.R.; Cassata, G.
The Caenorhabditis elegans elongator complex regulates neuronal alpha-tubulin acetylation
PLoS Genet.
6
e1000820
2010
Caenorhabditis elegans
Manually annotated by BRENDA team
Topalidou, I.; Keller, C.; Kalebic, N.; Nguyen, K.C.; Somhegyi, H.; Politi, K.A.; Heppenstall, P.; Hall, D.H.; Chalfie, M.
Genetically separable functions of the MEC-17 tubulin acetyltransferase affect microtubule organization
Curr. Biol.
22
1057-1065
2012
Caenorhabditis elegans
Manually annotated by BRENDA team
Castro-Castro, A.; Janke, C.; Montagnac, G.; Paul-Gilloteaux, P.; Chavrier, P.
ATAT1/MEC-17 acetyltransferase and HDAC6 deacetylase control a balance of acetylation of alpha-tubulin and cortactin and regulate MT1-MMP trafficking and breast tumor cell invasion
Eur. J. Cell Biol.
91
950-960
2012
Homo sapiens
Manually annotated by BRENDA team
Akella, J.S.; Wloga, D.; Kim, J.; Starostina, N.G.; Lyons-Abbott, S.; Morrissette, N.S.; Dougan, S.T.; Kipreos, E.T.; Gaertig, J.
MEC-17 is an alpha-tubulin acetyltransferase
Nature
467
218-222
2010
Caenorhabditis elegans, Chlamydomonas reinhardtii, Danio rerio, Mus musculus, Tetrahymena thermophila
Manually annotated by BRENDA team
Leroux, M.
Tubulin acetyltransferase discovered: ciliary role in the ancestral eukaryote expanded to neurons in metazoans
Proc. Natl. Acad. Sci. USA
107
21238-21239
2010
Caenorhabditis elegans, Homo sapiens, Tetrahymena sp.
Manually annotated by BRENDA team
Shida, T.; Cueva, J.G.; Xu, Z.; Goodman, M.B.; Nachury, M.V.
The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation
Proc. Natl. Acad. Sci. USA
107
21517-21522
2010
Caenorhabditis elegans, no activity in Potorous tridactylis
Manually annotated by BRENDA team
Yang, W.; Guo, X.; Thein, S.; Xu, F.; Sugii, S.; Baas, P.; Radda, G.; Han, W.
Regulation of adipogenesis by cytoskeleton remodelling is facilitated by acetyltransferase MEC-17-dependent acetylation of alpha-tubulin
Biochem. J.
449
605-612
2013
Mus musculus (Q8K341)
Manually annotated by BRENDA team
Yuzawa, S.; Kamakura, S.; Hayase, J.; Sumimoto, H.
Structural basis of cofactor-mediated stabilization and substrate recognition of the alpha-tubulin acetyltransferase alphaTAT1
Biochem. J.
467
103-113
2015
Homo sapiens (Q5SQI0)
Manually annotated by BRENDA team
Neumann, B.; Hilliard, M.A.
Loss of MEC-17 leads to microtubule instability and axonal degeneration
Cell Rep.
6
93-103
2014
Caenorhabditis elegans
Manually annotated by BRENDA team
Szyk, A.; Deaconescu, A.M.; Spector, J.; Goodman, B.; Valenstein, M.L.; Ziolkowska, N.E.; Kormendi, V.; Grigorieff, N.; Roll-Mecak, A.
Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase
Cell
157
1405-1415
2014
Homo sapiens (Q5SQI0)
Manually annotated by BRENDA team
Davenport, A.M.; Collins, L.N.; Chiu, H.; Minor, P.J.; Sternberg, P.W.; Hoelz, A.
Structural and functional characterization of the alpha-tubulin acetyltransferase MEC-17
J. Mol. Biol.
426
2605-2616
2014
Homo sapiens (Q5SQI0), Homo sapiens
Manually annotated by BRENDA team
Nakakura, T.; Suzuki, T.; Nemoto, T.; Tanaka, H.; Asano-Hoshino, A.; Arisawa, K.; Nishijima, Y.; Kiuchi, Y.; Hagiwara, H.
Intracellular localization of alpha-tubulin acetyltransferase ATAT1 in rat ciliated cells
Med. Mol. Morphol.
49
133-143
2016
Rattus norvegicus
Manually annotated by BRENDA team
Howes, S.C.; Alushin, G.M.; Shida, T.; Nachury, M.V.; Nogales, E.
Effects of tubulin acetylation and tubulin acetyltransferase binding on microtubule structure
Mol. Biol. Cell
25
257-266
2014
Homo sapiens (Q5SQI0)
Manually annotated by BRENDA team
Kalebic, N.; Martinez, C.; Perlas, E.; Hublitz, P.; Bilbao-Cortes, D.; Fiedorczuk, K.; Andolfo, A.; Heppenstall, P.A.
Tubulin acetyltransferase alphaTAT1 destabilizes microtubules independently of its acetylation activity
Mol. Cell. Biol.
33
1114-1123
2013
Mus musculus (Q8K341)
Manually annotated by BRENDA team
Kalebic, N.; Sorrentino, S.; Perlas, E.; Bolasco, G.; Martinez, C.; Heppenstall, P.
alphaTAT1 is the major alpha-tubulin acetyltransferase in mice
Nat. Commun.
4
1962
2013
Mus musculus (Q8K341), Mus musculus
Manually annotated by BRENDA team
Wang, B.; Rao, Y.H.; Inoue, M.; Hao, R.; Lai, C.H.; Chen, D.; McDonald, S.L.; Choi, M.C.; Wang, Q.; Shinohara, M.L.; Yao, T.P.
Microtubule acetylation amplifies p38 kinase signalling and anti-inflammatory IL-10 production
Nat. Commun.
5
3479
2014
Mus musculus
Manually annotated by BRENDA team
Montagnac, G.; Meas-Yedid, V.; Irondelle, M.; Castro-Castro, A.; Franco, M.; Shida, T.; Nachury, M.V.; Benmerah, A.; Olivo-Marin, J.C.; Chavrier, P.
alphaTAT1 catalyses microtubule acetylation at clathrin-coated pits
Nature
502
567-570
2013
Homo sapiens (Q5SQI0)
Manually annotated by BRENDA team
Zhou, H.; Cheng, X.; Xu, X.; Jiang, T.; Zhou, H.; Sheng, Q.; Nie, Z.
Cloning, expression profiling, and acetylation identification of alpha-tubulin N-acetyltransferase 1 from Bombyx mori
Arch. Insect Biochem. Physiol.
98
e21463
2018
Bombyx mori (H9IXT4), Bombyx mori
Manually annotated by BRENDA team
Stoner, M.W.; Thapa, D.; Zhang, M.; Gibson, G.A.; Calderon, M.J.; St Croix, C.M.; Scott, I.
alpha-Lipoic acid promotes alpha-tubulin hyperacetylation and blocks the turnover of mitochondria through mitophagy
Biochem. J.
473
1821-1830
2016
Chlorocebus aethiops
Manually annotated by BRENDA team
Morelli, G.; Even, A.; Gladwyn-Ng, I.; Le Bail, R.; Shilian, M.; Godin, J.D.; Peyre, E.; Hassan, B.A.; Besson, A.; Rigo, J.M.; Weil, M.; Brone, B.; Nguyen, L.
p27Kip1 modulates axonal transport by regulating alpha-tubulin acetyltransferase 1 stability
Cell Rep.
23
2429-2442
2018
Mus musculus (Q8K341)
Manually annotated by BRENDA team
Borgen, M.; Giles, A.; Wang, D.; Grill, B.
Synapse maintenance is impacted by ATAT-2 tubulin acetyltransferase activity and the RPM-1 signaling hub
eLife
8
e44040
2019
Caenorhabditis elegans (Q23192)
Manually annotated by BRENDA team
Wong, V.; Picci, C.; Swift, M.; Levinson, M.; Willis, D.; Langley, B.
alpha-Tubulin acetyltransferase s a novel target mediating neurite growth inhibitory effects of chondroitin sulfate proteoglycans and myelin-associated glycoprotein
eNeuro
5
e0240
2018
Mus musculus (Q8K341)
Manually annotated by BRENDA team
Fiorentino, F.; Mai, A.; Rotili, D.
Lysine acetyltransferase inhibitors structure-activity relationships and potential therapeutic implications
Future Med. Chem.
10
1067-1091
2018
Homo sapiens (Q5SQI0), Homo sapiens
Manually annotated by BRENDA team
Nekooki-Machida, Y.; Nakakura, T.; Nishijima, Y.; Tanaka, H.; Arisawa, K.; Kiuchi, Y.; Miyashita, T.; Hagiwara, H.
Dynamic localization of alpha-tubulin acetyltransferase ATAT1 through the cell cycle in human fibroblastic KD cells
Med. Mol. Morphol.
51
217-226
2018
Homo sapiens (Q5SQI0), Homo sapiens
Manually annotated by BRENDA team
Coombes, C.; Yamamoto, A.; McClellan, M.; Reid, T.A.; Plooster, M.; Luxton, G.W.; Alper, J.; Howard, J.; Gardner, M.K.
Mechanism of microtubule lumen entry for the alpha-tubulin acetyltransferase enzyme alphaTAT1
Proc. Natl. Acad. Sci. USA
113
E7176-E7184
2016
Homo sapiens (Q5SQI0)
Manually annotated by BRENDA team
Lee, C.; Cheng, Y.; Chang, C.; Lin, C.; Chang, J.
Alpha-tubulin acetyltransferase/MEC-17 regulates cancer cell migration and invasion through epithelial-mesenchymal transition suppression and cell polarity disruption
Sci. Rep.
8
17477
2018
Homo sapiens (Q5SQI0)
Manually annotated by BRENDA team