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2.3.1.108: alpha-tubulin N-acetyltransferase

This is an abbreviated version!
For detailed information about alpha-tubulin N-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.108

Reaction

acetyl-CoA
+
[alpha-tubulin]-L-lysine
=
CoA
+
[alpha-tubulin]-N6-acetyl-L-lysine

Synonyms

acetyl-CoA:alpha-tubulin-L-lysine Ne-acetyltransferase, alpha-TAT, alpha-tubulin acetylase, alpha-tubulin acetyltransferase, alpha-tubulin K40 acetyltransferase, alpha-tubulin N-acetyltransferase 1, alphaTAT, alphaTAT1, alphaTAT2, ATAT-2, ATAT1, ATAT1 acetylase, ATAT1 tubulin acetyltransferase, elongator, KAT, lysine acetyltransferase, Mec-17, TAT, tubulin acetyltransferase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.108 alpha-tubulin N-acetyltransferase

Expression

Expression on EC 2.3.1.108 - alpha-tubulin N-acetyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
construction of a Mec-17 disruption mutant. The MEC-17-KO Tetrahymena cells have a normal growth rate, but theMEC-17-KOcells grow more slowly than wild type on medium with the microtubule depolymerizing compound oryzalin. Conversely, the MEC-17 KO cells grew faster than wild-type cells in medium with paclitaxel, a microtubule-stabilizing drug. This drug phenotype is consistent with an increase in dynamics of microtubules in MEC17-KO cells
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