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2.3.1.108: alpha-tubulin N-acetyltransferase

This is an abbreviated version!
For detailed information about alpha-tubulin N-acetyltransferase, go to the full flat file.

Word Map on EC 2.3.1.108

Reaction

acetyl-CoA
+
[alpha-tubulin]-L-lysine
=
CoA
+
[alpha-tubulin]-N6-acetyl-L-lysine

Synonyms

acetyl-CoA:alpha-tubulin-L-lysine Ne-acetyltransferase, alpha-TAT, alpha-tubulin acetylase, alpha-tubulin acetyltransferase, alpha-tubulin K40 acetyltransferase, alpha-tubulin N-acetyltransferase 1, alphaTAT, alphaTAT1, alphaTAT2, ATAT-2, ATAT1, ATAT1 acetylase, ATAT1 tubulin acetyltransferase, elongator, KAT, lysine acetyltransferase, Mec-17, TAT, tubulin acetyltransferase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.108 alpha-tubulin N-acetyltransferase

Disease

Disease on EC 2.3.1.108 - alpha-tubulin N-acetyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
alpha-tubulin n-acetyltransferase deficiency
Deregulated expression of pro-survival and pro-apoptotic p53-dependent genes upon Elongator deficiency in colon cancer cells.
Germline Elongator mutations in Sonic Hedgehog medulloblastoma.
MEC-17 Deficiency Leads to Reduced ?-Tubulin Acetylation and Impaired Migration of Cortical Neurons.
Amyotrophic Lateral Sclerosis
Animal and cellular models of familial dysautonomia.
The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation.
The Many Faces of Elongator in Neurodevelopment and Disease.
Ataxia Telangiectasia
MYST family lysine acetyltransferase facilitates ataxia telangiectasia mutated (ATM) kinase-mediated DNA damage response in Toxoplasma gondii.
Breast Neoplasms
KAT6A, a novel regulator of ?-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1.
Microtubule Acetylation Controls MDA-MB-231 Breast Cancer Cell Invasion through the Modulation of Endoplasmic Reticulum Stress.
Carcinogenesis
A bivalent role of TIP60 histone acetyl transferase in human cancer.
KATapulting toward Pluripotency and Cancer.
Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis.
Role of histone acetyltransferase inhibitors in cancer therapy.
Carcinoma
Inhibition of p300 lysine acetyltransferase activity by luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model.
Carcinoma, Hepatocellular
Elongator promotes the migration and invasion of hepatocellular carcinoma cell by the phosphorylation of AKT.
Carcinoma, Non-Small-Cell Lung
Lysine Acetyltransferase GCN5 Potentiates the Growth of Non-Small Cell Lung Cancer via Promotion of E2F1, Cyclin D1 and Cyclin E1 Expression.
Carcinoma, Squamous Cell
Inhibition of p300 lysine acetyltransferase activity by luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model.
Cerebellar Ataxia
Elongator mutation in mice induces neurodegeneration and ataxia-like behavior.
Colonic Neoplasms
Deregulated expression of pro-survival and pro-apoptotic p53-dependent genes upon Elongator deficiency in colon cancer cells.
Genetic disruption of tubulin acetyltransferase, ?TAT1, inhibits proliferation and invasion of colon cancer cells through decreases in Wnt1/?-catenin signaling.
Colorectal Neoplasms
Long non-coding RNA DANCR promotes colorectal tumor growth by binding to lysine acetyltransferase 6A.
Confusion
A coordinated codon-dependent regulation of translation by Elongator.
Coronary Disease
Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies.
Cystic Fibrosis
4-Phenylbutyrate stimulates Hsp70 expression through the Elp2 component of elongator and STAT-3 in cystic fibrosis epithelial cells.
Cysts
Toxoplasma gondii lysine acetyltransferase GCN5-A functions in the cellular response to alkaline stress and expression of cyst genes.
Deafness
Proteostasis is essential during cochlear development for neuron survival and hair cell polarity.
Diphtheria
A versatile partner of eukaryotic protein complexes that is involved in multiple biological processes: Kti11/Dph3.
Dysautonomia, Familial
A conserved and essential basic region mediates tRNA binding to the Elp1 subunit of the Saccharomyces cerevisiae Elongator complex.
Defects in tRNA modification associated with neurological and developmental dysfunctions in Caenorhabditis elegans elongator mutants.
Elongator - an emerging role in neurological disorders.
Elongator and codon bias regulate protein levels in mammalian peripheral neurons.
Elongator complex: how many roles does it play?
ELP1 Splicing Correction Reverses Proprioceptive Sensory Loss in Familial Dysautonomia.
Exon-specific U1 snRNAs improve ELP1 exon 20 definition and rescue ELP1 protein expression in a familial dysautonomia mouse model.
Female-Specific Association Between Variants on Chromosome 9 and Self-Reported Diagnosis of Irritable Bowel Syndrome.
Potential role of tubulin acetylation and microtubule-based protein trafficking in familial dysautonomia.
Purification and characterization of the human elongator complex.
Structural insights into the function of Elongator.
The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation.
The Familial Dysautonomia disease gene, Ikbkap/Elp1, is required in the developing and adult central nervous system.
The Many Faces of Elongator in Neurodevelopment and Disease.
Transcription impairment and cell migration defects in elongator-depleted cells: implication for familial dysautonomia.
[Molecular and cellular characterization ion of IKAP protein and the Elongator complex. Implications for familial dysautonomia]
Epilepsy
Association of brain-derived neurotrophic factor (BDNF) and elongator protein complex 4 (ELP4) polymorphisms with benign epilepsy with centrotemporal spikes in a Greek population.
Epilepsy, Rolandic
Animal and cellular models of familial dysautonomia.
Association of brain-derived neurotrophic factor (BDNF) and elongator protein complex 4 (ELP4) polymorphisms with benign epilepsy with centrotemporal spikes in a Greek population.
Centrotemporal sharp wave EEG trait in rolandic epilepsy maps to Elongator Protein Complex 4 (ELP4).
The Many Faces of Elongator in Neurodevelopment and Disease.
Genetic Diseases, Inborn
De Novo KAT5 Variants Cause a Syndrome with Recognizable Facial Dysmorphisms, Cerebellar Atrophy, Sleep Disturbance, and Epilepsy.
Exon-specific U1 snRNAs improve ELP1 exon 20 definition and rescue ELP1 protein expression in a familial dysautonomia mouse model.
[Molecular and cellular characterization ion of IKAP protein and the Elongator complex. Implications for familial dysautonomia]
Glioblastoma
Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5.
KAT6A, a novel regulator of ?-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1.
Glioma
Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5.
Hereditary Sensory and Autonomic Neuropathies
The Familial Dysautonomia disease gene, Ikbkap/Elp1, is required in the developing and adult central nervous system.
Hypersensitivity
Elongator mediates ABA responses, oxidative stress resistance and anthocyanin biosynthesis in Arabidopsis.
HAGLR aggravates neuropathic pain and promotes inflammatory response and apoptosis of lipopolysaccharide-treated SH-SY5Y cells by sequestering miR-182-5p from ATAT1 and activating NLRP3 inflammasome.
Infections
Acetylation of the Cd8 Locus by KAT6A Determines Memory T Cell Diversity.
Proteome-wide lysine acetylation in cortical astrocytes and alterations that occur during infection with brain parasite Toxoplasma gondii.
Infertility, Male
Expression and localization of alpha-tubulin N-acetyltransferase 1 in the reproductive system of male mice.
Intellectual Disability
Animal and cellular models of familial dysautonomia.
Five new cases of syndromic intellectual disability due to KAT6A mutations: widening the molecular and clinical spectrum.
Histone acetylation deficits in lymphoblastoid cell lines from patients with Rubinstein-Taybi syndrome.
Submicroscopic 11p13 deletion including the elongator acetyltransferase complex subunit 4 gene in a girl with language failure, intellectual disability and congenital malformations: A case report.
The Many Faces of Elongator in Neurodevelopment and Disease.
Language Development Disorders
Five new cases of syndromic intellectual disability due to KAT6A mutations: widening the molecular and clinical spectrum.
Leukemia
KAT6A, a novel regulator of ?-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1.
The high-performance technology CRISPR/Cas9 improves the knowledge and management of acute myeloid leukemia.
Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP.
Leukemia, Myeloid, Acute
miR-143-3p represses leukemia cell proliferation by inhibiting KAT6A expression.
Lung Neoplasms
Alpha-tubulin acetyltransferase/MEC-17 regulates cancer cell migration and invasion through epithelial-mesenchymal transition suppression and cell polarity disruption.
Lysine Acetyltransferase GCN5 Potentiates the Growth of Non-Small Cell Lung Cancer via Promotion of E2F1, Cyclin D1 and Cyclin E1 Expression.
Medulloblastoma
Germline Elongator mutations in Sonic Hedgehog medulloblastoma.
Melanoma
DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator.
Muscle Hypotonia
Five new cases of syndromic intellectual disability due to KAT6A mutations: widening the molecular and clinical spectrum.
Myocardial Ischemia
A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes.
Neoplasm Metastasis
Alpha-tubulin acetyltransferase/MEC-17 regulates cancer cell migration and invasion through epithelial-mesenchymal transition suppression and cell polarity disruption.
Elongator promotes the migration and invasion of hepatocellular carcinoma cell by the phosphorylation of AKT.
Neoplasms
A bivalent role of TIP60 histone acetyl transferase in human cancer.
Alpha-tubulin acetyltransferase/MEC-17 regulates cancer cell migration and invasion through epithelial-mesenchymal transition suppression and cell polarity disruption.
Deciphering structure, function and mechanism of lysine acetyltransferase HBO1 in protein acetylation, transcription regulation, DNA replication and its oncogenic properties in cancer.
Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine.
Genetic disruption of tubulin acetyltransferase, ?TAT1, inhibits proliferation and invasion of colon cancer cells through decreases in Wnt1/?-catenin signaling.
Germline Elongator mutations in Sonic Hedgehog medulloblastoma.
Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding.
Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5.
Inhibition of lysine acetyltransferases impairs tumor angiogenesis acting on both endothelial and tumor cells.
Inhibition of p300 lysine acetyltransferase activity by luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model.
Low Expression of KAT6B May Affect Prognosis in Hepatocellular Carcinoma.
Microtubule Acetylation Controls MDA-MB-231 Breast Cancer Cell Invasion through the Modulation of Endoplasmic Reticulum Stress.
Molecular basis of tRNA recognition by the Elongator complex.
Nuclear Localization Is Not Required for Tip60 Tumor Suppressor Activity in Breast and Lung Cancer Cells.
Promotion of cell proliferation by the proto-oncogene DEK enhances oral squamous cell carcinogenesis through field cancerization.
Protein N-terminal acetyltransferases in cancer.
Role of histone acetyltransferase inhibitors in cancer therapy.
Roles of Elongator Dependent tRNA Modification Pathways in Neurodegeneration and Cancer.
Structural basis for tRNA modification by Elp3 from Dehalococcoides mccartyi.
Structures and Activities of the Elongator Complex and Its Cofactors.
The biology of lysine acetylation integrates transcriptional programming and metabolism.
The multifaceted role of lysine acetylation in cancer: prognostic biomarker and therapeutic target.
TIP60 inhibits metastasis by ablating DNMT1-SNAIL2-driven epithelial-mesenchymal transition program.
TIP60 represses activation of endogenous retroviral elements.
Nervous System Diseases
Elongator - an emerging role in neurological disorders.
Elongator mutation in mice induces neurodegeneration and ataxia-like behavior.
Structures and Activities of the Elongator Complex and Its Cofactors.
The Many Faces of Elongator in Neurodevelopment and Disease.
Neuralgia
HAGLR aggravates neuropathic pain and promotes inflammatory response and apoptosis of lipopolysaccharide-treated SH-SY5Y cells by sequestering miR-182-5p from ATAT1 and activating NLRP3 inflammasome.
Neuroblastoma
Loss of Elp3 Impairs the Acetylation and Distribution of Connexin-43 in the Developing Cerebral Cortex.
Neurodegenerative Diseases
Elongator: an ancestral complex driving transcription and migration through protein acetylation.
ELP1 Splicing Correction Reverses Proprioceptive Sensory Loss in Familial Dysautonomia.
Molecular basis of tRNA recognition by the Elongator complex.
Proteasome inhibitors to alleviate aberrant IKBKAP mRNA splicing and low IKAP/hELP1 synthesis in familial dysautonomia.
Structural basis for tRNA modification by Elp3 from Dehalococcoides mccartyi.
The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation.
The Elp2 subunit is essential for elongator complex assembly and functional regulation.
The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS.
Primary Dysautonomias
[Molecular and cellular characterization ion of IKAP protein and the Elongator complex. Implications for familial dysautonomia]
Rett Syndrome
Expanding the genetic landscape of Rett syndrome to include lysine acetyltransferase 6A (KAT6A).
Rubinstein-Taybi Syndrome
Histone acetylation deficits in lymphoblastoid cell lines from patients with Rubinstein-Taybi syndrome.
Scoliosis
High methylation of lysine acetyltransferase 6B is associated with the Cobb angle in patients with congenital scoliosis.
Squamous Cell Carcinoma of Head and Neck
Inhibition of p300 lysine acetyltransferase activity by luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model.
Stomach Neoplasms
Nuclear Localization Is Not Required for Tip60 Tumor Suppressor Activity in Breast and Lung Cancer Cells.
Synovitis
Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells.
Tauopathies
Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy.
Tuberculosis
A Lysine Acetyltransferase Contributes to the Metabolic Adaptation to Hypoxia in Mycobacterium tuberculosis.
Vitiligo
A Novel Pro-Melanogenic Effect of Standardized Dry Olive Leaf Extract on Primary Human Melanocytes from Lightly Pigmented and Moderately Pigmented Skin.