2.2.1.9: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase

This is an abbreviated version!
For detailed information about 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase, go to the full flat file.

Word Map on EC 2.2.1.9

2.2.1.9

menaquinone

thiamin

thdp-dependent

diphosphate-dependent

alpha-ketoglutarate

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic

dioxide

benzoylformate

decarboxylases

stereoselective

hydrolases

alpha/beta

o-succinylbenzoic

metal-ion-dependent

three-domain

two-stage

medium-resolution

Reaction

5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate

Synonyms

(1R,2S,5S,6S)-2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, (1R,2S,5S,6S)-2-succinyl-5-enolpyruvyl-6-hydroxycyclohex-3-ene-1-carboxylate synthase, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic acid synthase, EC 2.5.1.64, EcMenD, MenD, Rv0555, SEPHCHC synthase, SHCHC synthase

ECTree

2 Transferases

2.2 Transferring aldehyde or ketonic groups

2.2.1 Transketolases and transaldolases

2.2.1.9 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase

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Results	in table
1	Activating Compound
13334	AA Sequence
1	CAS Registry Number
7	Cloned(Commentary)
10	Cofactor
8	Crystallization (Commentary)
6	General Information
3	General Stability
3	IC50 Value
5	Inhibitors
37	kcat/KM [mM/s]
3	Ki Value [mM]
44	KM Value [mM]
7	Metals/Ions
3	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
207	Organism
6	Pathway
153	PDB ID
3	pH Optimum
34	Protein Variants
8	Purification (Commentary)
4	Reaction
1	Reaction Type
17	Reference
1	Storage Stability
43	Substrates and Products (Substrate)
7	Subunits
41	Synonyms
1	Systematic Name
1	Temperature Stability [°C]
41	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.2.1.9 - 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase

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isochorismate + 2-oxoglutarate

5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2

8 entries

isochorismate + 2-oxoglutarate

5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate + CO2

Escherichia coli

P17109

745170

additional information

Escherichia coli

MenD participates in the menaquinone (vitamin K2) biosynthetic pathway

684159