2.2.1.5: 2-hydroxy-3-oxoadipate synthase
This is an abbreviated version!
For detailed information about 2-hydroxy-3-oxoadipate synthase, go to the full flat file.
Word Map on EC 2.2.1.5
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2.2.1.5
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thiamin
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acetaldehyde
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benzaldehyde
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diphosphate-dependent
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carboligation
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thdp-dependent
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zymomonas
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r-phenylacetylcarbinol
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mobilis
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benzoylformate
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hyperoxaluria
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utilis
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r-benzoin
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enamine
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1',4'-iminopyrimidine
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thdp-bound
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thiamine-deficient
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medicine
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synthesis
- 2.2.1.5
- thiamin
- acetaldehyde
- benzaldehyde
-
diphosphate-dependent
-
carboligation
-
thdp-dependent
-
zymomonas
-
r-phenylacetylcarbinol
- mobilis
- benzoylformate
- hyperoxaluria
- utilis
-
r-benzoin
-
enamine
-
1',4'-iminopyrimidine
-
thdp-bound
-
thiamine-deficient
- medicine
- synthesis
Reaction
Synonyms
(R)-HOA synthase, 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating), 2-hydroxy-3-oxoadipate synthase, 2-oxoglutarate: glyoxylate carboligase, alpha-ketoglutarate:glyoxylate carboligase, alpha-ketoglutaric-glyoxylic carboligase, carboligase, EC 4.1.3.15, glyoxylate-2-oxoglutarate carboligase, HOA synthase, HOAS, oxoglutarate: glyoxylate carboligase, Rv1248c
ECTree
2.2.1.5 2-hydroxy-3-oxoadipate synthaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.2.1.5 - 2-hydroxy-3-oxoadipate synthase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-oxoglutarate + glyoxylate
2-hydroxy-3-oxoadipate + CO2
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?
2-oxoglutarate + glyoxylate
2-hydroxy-3-oxoadipate + CO2
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?
2-oxoglutarate + glyoxylate
2-hydroxy-3-oxoadipate + CO2
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?
2-oxoglutarate + glyoxylate
?
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possible 1-carbon source for nicotine synthesis
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?
2-oxoglutarate + glyoxylate
?
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important as diversion of glyoxylate from oxalate formation
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?
2-oxoglutarate + glyoxylate
?
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hypothesized 2-oxoglutarate regeneration cycle
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?
additional information
?
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catalyzing C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of a second substrate, glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA)
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-
?
additional information
?
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catalyzing C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of a second substrate, glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA)
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-
?
additional information
?
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Rv1248c catalyzes C-C bond formation between the activated aldehyde of alpha-ketoglutarate and the carbonyl of glyoxylate to yield 2-hydroxy-3-oxoadipate (HOA), which decomposes to 5-hydroxylevulinate
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-
?
additional information
?
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Rv1248c catalyzes C-C bond formation between the activated aldehyde of alpha-ketoglutarate and the carbonyl of glyoxylate to yield 2-hydroxy-3-oxoadipate (HOA), which decomposes to 5-hydroxylevulinate
-
-
?
additional information
?
-
catalyzing C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of a second substrate, glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA)
-
-
?
additional information
?
-
Rv1248c catalyzes C-C bond formation between the activated aldehyde of alpha-ketoglutarate and the carbonyl of glyoxylate to yield 2-hydroxy-3-oxoadipate (HOA), which decomposes to 5-hydroxylevulinate
-
-
?
