2.2.1.10: 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
This is an abbreviated version!
For detailed information about 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase, go to the full flat file.
Word Map on EC 2.2.1.10
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2.2.1.10
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dehydrogenases
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melanogaster
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medium-chain
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zinc-containing
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4-methylpyrazole
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brockii
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thermoanaerobacter
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quinoprotein
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cline
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pasteurianus
- 2.2.1.10
- dehydrogenases
- melanogaster
-
medium-chain
-
zinc-containing
- 4-methylpyrazole
- brockii
- thermoanaerobacter
-
quinoprotein
- cline
- pasteurianus
Reaction
Synonyms
ADHS, 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, ADH synthase, ADHS, MJ0400, More
ECTree
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General Information
General Information on EC 2.2.1.10 - 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
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evolution
ADH synthase is a member of the class I aldolase superfamily
metabolism
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, the product of the Mj0400 gene, catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate and L-aspartate semialdehyde to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid, i.e. ADH. Dehydroquinate synthase II, the product of the Mj1249 gene, then catalyzes deamination and cyclization of ADH, resulting in DHQ, which is fed into the canonical pathway
metabolism
Mj0400 is involved in the biosynthesis of aromatic compounds, including 3-dehydroquinate via an undetermined intermediate and 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid, which is formed by NAD+-dependent Mj1249 from the intermediate compound. Also 4,5-dihydroxy-6-methylpipecolinic acid is formed from the intermediate. Pathway analysis, detailed overview
metabolism
the enzyme is involved in both carbon metabolism and amino acid biosynthesis, it catalyzes as transaldolase a step leading to biosynthesis of 3-dehydroquinate, which enters the shikimate pathway, and also shows activity as fructose 1,6-bisphosphate aldolase in carbon metabolism, overview