2.2.1.1: transketolase
This is an abbreviated version!
For detailed information about transketolase, go to the full flat file.
Word Map on EC 2.2.1.1
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2.2.1.1
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thiamin
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pentose
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erythrocyte
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pyrophosphate
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transaldolase
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glucose-6-phosphate
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tpp
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ribose
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5-phosphate
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aldolase
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non-oxidative
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glycation
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encephalopathy
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pyridoxine
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apoenzyme
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phosphoglycerate
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wernicke
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baker
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oxythiamine
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neuropathy
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ribose-5-phosphate
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thiamine-deficient
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xylulose
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thiamine-dependent
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6-phosphogluconate
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riboflavin
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calvin
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pharmacology
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drug development
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biotechnology
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pentose-phosphate
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xylulokinase
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industry
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alpha-ketoglutarate
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dihydroxyacetone
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warburg
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phosphoketolase
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3-epimerase
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hemolysates
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pyrophosphokinase
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xylitol
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phosphoribulokinase
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thiaminase
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hydroxypyruvate
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aminopyrimidine
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fructose-6-phosphate
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medicine
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fructose-1,6-bisphosphate
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antivitaminous
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erythrose
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egypt
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thdp-dependent
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diphosphate-dependent
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synthesis
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isotopomer
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analysis
- 2.2.1.1
- thiamin
- pentose
- erythrocyte
- pyrophosphate
- transaldolase
- glucose-6-phosphate
- tpp
- ribose
- 5-phosphate
- aldolase
-
non-oxidative
-
glycation
- encephalopathy
- pyridoxine
-
apoenzyme
- phosphoglycerate
- wernicke
-
baker
- oxythiamine
- neuropathy
- ribose-5-phosphate
-
thiamine-deficient
- xylulose
-
thiamine-dependent
- 6-phosphogluconate
- riboflavin
-
calvin
- pharmacology
- drug development
- biotechnology
-
pentose-phosphate
- xylulokinase
- industry
- alpha-ketoglutarate
- dihydroxyacetone
-
warburg
- phosphoketolase
-
3-epimerase
- hemolysates
-
pyrophosphokinase
- xylitol
- phosphoribulokinase
- thiaminase
- hydroxypyruvate
- aminopyrimidine
- fructose-6-phosphate
- medicine
- fructose-1,6-bisphosphate
-
antivitaminous
- erythrose
-
egypt
-
thdp-dependent
-
diphosphate-dependent
- synthesis
-
isotopomer
- analysis
Reaction
Synonyms
glycolaldehydetransferase, STM14_2885, STM14_2886, TK16, TKA, TKL, TKL1, Tkl2, TKT, TKT10, TKT3, TKT7, TktA, TktB, TKTc, TKTL-1, TKTL1, TKTL2, TKTp, transketolase, transketolase 10, transketolase 3, transketolase 7, transketolase A, transketolase B, transketolase like 1, transketolase-1, transketolase-like 1, transketolase-like enzyme 1, transketolase-like-1, transketolase-like-1-gene, transketolase-like-2
ECTree
2.2.1.1 transketolaseAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 2.2.1.1 - transketolase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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adult bone marrow-derived insulin-producing cells, presence of transketolase protein under high-glucose conditions
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only 29% of non-neoplastic breast tissues are TKTL1 immunopositive, including 9% with high expression levels
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TKTL1 expression in 86% of breast cancer specimens with 45% showing high expression levels
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thiamine-deficinet diet reduces transketolase activity in both cortex and hippocampus, without significantly affecting the activities of pyruvate dehydrogenase, alpha-ketoglutamate dehydrogenase, and glucose 6-phosphate dehydrogenase
compared with grades II and III astrocytic gliomas, glioblastoma multiformes show higher expression of TKTL1
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thiamine-deficient diet reduces transketolase activity in both cortex and hippocampus, without significantly affecting the activities of pyruvate dehydrogenase, alpha-ketoglutamate dehydrogenase, and glucose 6-phosphate dehydrogenase
transketolase activity is significantly higher in nasopharyngeal carcinoma tissues than in chronic nasopharyngitis tissues. TKTL1 in human nasopharyngeal carcinoma tissues is upregulated, whereas TKT is not upregulated
transketolase is mainly expressed by oligodendrocytes in normal conditions, but is also present in oligodendrocytes in normal appearing white matter around multiple sclerosis plaques
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enzyme is highly expressed at 2 hours of spontaneous maturation in oocytes
additional information
in normal human brain transketolase is expressed on almost the totality of mature oligodendrocytes and scattered NG2-positive precursors, diffusely on ependymal cells and on distinct subsets of neuronal populations
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papillary thyroid carcinoma with or without lymph-node metastases
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insulinoma cell line. Proliferation of cells is not inhibited by transketolase inhibitor benfotiamine
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rehydrated leaf, isoforms Tkt7 and Tkt10 are upregulated upon rehydration of desiccated plants
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parenchymal cell. Transketolase activity is present in peroxisomes and at membranes of granular endoplasmic reticulum
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significantly elevated expression of TKTL1 in serous papillary carcinomas in comparison to mucinous carcinomas, borderline tumors, and normal control ovarian tissue, which correlates with poor prognostic parameters
additional information
diffuse expression of transketolase in ependymal cells of normal human brain. At the lesion border transketolase is expressed by oligodendrocyte precursors (NG2-positive precursor)
additional information
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diffuse expression of transketolase in ependymal cells of normal human brain. At the lesion border transketolase is expressed by oligodendrocyte precursors (NG2-positive precursor)
additional information
in human nasopharyngeal carcinoma tissues, TKT and TKTL2 are not upregulated
additional information
in human nasopharyngeal carcinoma tissues, TKT and TKTL2 are not upregulated
additional information
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in human nasopharyngeal carcinoma tissues, TKT and TKTL2 are not upregulated
additional information
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in ONCO-DG-1 cells TKTL-1 is highly expressed. Present in FTC-238 cells and CGTH-W-1 cells. TKTL-1 is absent from normal thyrocytes
additional information
LGSIL cell, low-grade squamous intraepithelial lesions, low expression of TKTL1. HGSIL cell, high-grade squamous intraepithelial lesions, high expression of TKTL1. ISCC cell, invasive squamous cell carcinomas, highest expression of TKTL1
additional information
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mucinous ovarian carcinoma tissue and borderline tumor tissue
additional information
TKTL1 is significantly overexpressed in tumors of astrocytic gliomas. Tumor grade significantly correlates with expression of TKTL1
additional information
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BM-derived IPC cell, in bone marrow derived insulin-producing cells, transketolase is detectable under high glucose culture conditions
additional information
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transketolase activity is absent from the long slender bloodstream form of the parasite and the protein is not detectable in this life cycle stage, with the RNA present only at low abundance
