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2.2.1.1: transketolase

This is an abbreviated version!
For detailed information about transketolase, go to the full flat file.

Word Map on EC 2.2.1.1

Reaction

sedoheptulose 7-phosphate
+
D-glyceraldehyde 3-phosphate
=
D-ribose 5-phosphate
+
D-xylulose 5-phosphate

Synonyms

glycolaldehydetransferase, STM14_2885, STM14_2886, TK16, TKA, TKL, TKL1, Tkl2, TKT, TKT10, TKT3, TKT7, TktA, TktB, TKTc, TKTL-1, TKTL1, TKTL2, TKTp, transketolase, transketolase 10, transketolase 3, transketolase 7, transketolase A, transketolase B, transketolase like 1, transketolase-1, transketolase-like 1, transketolase-like enzyme 1, transketolase-like-1, transketolase-like-1-gene, transketolase-like-2

ECTree

     2 Transferases
         2.2 Transferring aldehyde or ketonic groups
             2.2.1 Transketolases and transaldolases
                2.2.1.1 transketolase

Expression

Expression on EC 2.2.1.1 - transketolase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
after short-term oxidative stress (0.15 mM menadione), isoform TKL1 expression remains low
enzyme expression decreases after 24 h of chilling stress at 5°C
enzyme overexpression in cancer cells is a response of Nuclear Factor, Erythroid 2-Like 2 activation
-
expression of is up-regulated in the presence of xylose
hydrogen peroxide induces enzyme expression at 1 h treatment, while an increase in expression of the marRAB operon occurrs only after 3 h exposure and is dependent on the presence of the enzmye gene
-
in HeLa cells, transketolase-like enzyme 1 mRNA is specifically overexpressed compared with normal human endocervical epithelial cells
in response to short-term osmotic stress (20% glucose or 1.2 M NaCl), isoform TKL1 expression increases rapidly through the first 40 min before subsequently decreasing gradually. Long-term osmotic stress (20% glucose) yields increased expression of isoform TLK1 starting at 12 h and continuing through 72 h
in response to short-term osmotic stress (20% glucose or 1.2 M NaCl), isoform TKL2 expression shows no significant change
low temperature (5°C) and low light (0.1 mM m-2 s-1) induce enzyme expression
short-term oxidative stress (0.15 mM menadione) induces considerable increase in isoform TKL2. Long-term osmotic stress (20% glucose) yields increased expression of isoform TLK2 starting at 12 h and continuing through 72 h
the enzyme activity is rapidly decreased with the increase in H2O2 concentration (0-60 mM)
-
the enzyme is upregulated in metastatic peritoneal implants
-