2.1.3.7: 3-hydroxymethylcephem carbamoyltransferase

This is an abbreviated version!
For detailed information about 3-hydroxymethylcephem carbamoyltransferase, go to the full flat file.

Reaction

Synonyms

carbamoyltransferase, 3-hyroxymethylcephem

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.3 Carboxy- and carbamoyltransferases

                2.1.3.7 3-hydroxymethylcephem carbamoyltransferase

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Results	in table
22	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
2	Cofactor
1	General Stability
12	Inhibitors
1	Localization
2	Metals/Ions
1	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
6	Organism
4	Pathway
1	pH Optimum
1	pH Range
1	Purification (Commentary)
1	Reaction
1	Reaction Type
6	Reference
2	Storage Stability
7	Substrates and Products (Substrate)
1	Subunits
1	Synonyms
1	Systematic Name

Natural Substrates Products

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Natural Substrates Products on EC 2.1.3.7 - 3-hydroxymethylcephem carbamoyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

carbamoyl phosphate + a 3-hydroxymethyl ceph-3-em-4-carboxylate

phosphate + a 3-carbamoyloxymethylcephem

3 entries

carbamoyl phosphate + a 3-hydroxymethyl ceph-3-em-4-carboxylate

phosphate + a 3-carbamoyloxymethylcephem

Amycolatopsis lactamdurans

-

the cmcH gene - encoding 3-hydroxymethylcephem carbamoyltransferase - upstream region does not contain a functional promoter, suggesting that cmcH is transcribed as a part of a polycistronic mRNA

485956

-

-

?

carbamoyl phosphate + a 3-hydroxymethyl ceph-3-em-4-carboxylate

phosphate + a 3-carbamoyloxymethylcephem

Amycolatopsis lactamdurans

-

enzyme is involved in biosynthesis of cephamycin

485957

-

-

?

carbamoyl phosphate + a 3-hydroxymethyl ceph-3-em-4-carboxylate

phosphate + a 3-carbamoyloxymethylcephem

Streptomyces clavuligerus

-

catalyzes the synthesis of a wide range of carbamoyloxymethylcephems, e.g. cefuroxime

485955

-

-

?