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2.1.3.2: aspartate carbamoyltransferase

This is an abbreviated version!
For detailed information about aspartate carbamoyltransferase, go to the full flat file.

Word Map on EC 2.1.3.2

Reaction

Carbamoyl phosphate
+
L-aspartate
=
phosphate
 +
N-carbamoyl-L-aspartate

Synonyms

(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxyltransferase, ACT, aspartate carbamoyltransferase, aspartate carbamyltransferase, aspartate trans carbamoylase, aspartate transcarbamoylase, aspartate transcarbamylase, aspartic acid transcarbamoylase, aspartic carbamyltransferase, aspartic transcarbamylase, ATC, ATC domain of CAD, ATCase, CAD, carbamoylaspartotranskinase, carbamoyltransferase, aspartate, carbamylaspartotranskinase, L-aspartate transcarbamoylase, L-aspartate transcarbamylase, MJ1581, PYRB

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.3 Carboxy- and carbamoyltransferases
                2.1.3.2 aspartate carbamoyltransferase

KI Value

KI Value on EC 2.1.3.2 - aspartate carbamoyltransferase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000193
(2S)-2-(([hydroxy(hydroxymethyl)phosphoryl]acetyl)amino)butanedioic acid
-
-
0.000417
(2S)-2-(([hydroxy(oxido)-lambda5-phosphanyl]acetyl)amino)butanedioic acid
-
-
2.2
2,2-dimethylsuccinate
-
inhibition of catalytic subunits, C3
0.001
2-(4-hydroxy-2,4-dioxo-4lamdba5-[1,4]azaphosphinan-1-yl)-succinic acid
-
catalytic subunit of aspartate transcarbamoylase
7.5
3-phosphonopropanoic acid
-
-
0.00001
4,5-dicarboxy-2-ketopentylphosphonate
-
-
80
aspartate
-
substrate inhibition, complex of catalytic subunits, C3
0.0085
ATP
7 - 15
carbamoyl aspartate
13
carbamoylaspartate
-
noncompetitive vs. carbamoyl phosphate
0.0035
Carbonyldiphosphonate
-
-
0.1
CDP
1.1
chloride
-
inhibition of catalytic subunits, C3
0.007 - 0.037
CTP
0.032
dichlormethylenediphosphonate
-
-
0.0004 - 0.9
diphosphate
2
ethylamidocarbonylphosphonate
-
-
5.3
fumarate
-
inhibition of catalytic subunits, C3
0.02
hypophosphate
-
-
0.071
imidodiphosphonate
-
-
4.59 - 13.56
L-aspartate
0.17 - 1
Maleate
0.7
mesotartrate
-
inhibition of catalytic subunits, C3
0.037
Methylenediphosphonate
-
-
0.00021
N-(2-hydroxy-acetyl)-L-aspartic acid-phosphate
-
catalytic subunit of aspartate transcarbamoylase
0.000001 - 0.000027
N-(phosphonacetyl)-L-aspartate
0.000006
N-(Phosphonoacetyl)-L-aspartate
-
-
1.54
N-methyl phosphonoacetamide
-
-
0.000000621
N-phosphonacetyl-L-aspartate
-
pH and temperature not specified in the publication
0.000016
N-phosphonoacetyl-L-aspartate
-
-
0.05
N-phosphoryl-L-aspartate
-
-
0.00024
N-pyrophosphoryl-L-aspartate
-
-
0.002
O-phosphonoacetyl-oxosuccinate
-
-
0.175
peroxydiphosphonate
-
-
0.1 - 14
phosphate
0.66
phosphonoacetamide
-
-
0.15
Phosphonoacetate
-
-
0.022
Phosphonoformate
-
-
1.5
ribose-5-P
0.017
S-diphosphoryl-mercaptosuccinate
-
-
0.0055
S-phosphonoacetyl-mercaptosuccinate
-
-
1.6 - 3.5
succinate
0.00049
UMP
-
-
0.0085
UTP
additional information
additional information
-
Ki-values at varying concentrations of Asp and carbamoyl phosphate
-