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2.1.3.11: N-succinylornithine carbamoyltransferase

This is an abbreviated version!
For detailed information about N-succinylornithine carbamoyltransferase, go to the full flat file.

Word Map on EC 2.1.3.11

Reaction

Carbamoyl phosphate
+
N2-succinyl-L-ornithine
=
phosphate
 +
N-succinyl-L-citrulline

Synonyms

ArgF, N-succinyl-L-ornithine transcarbamylase, SOTC, SOTCase, succinylornithine transcarbamylase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.3 Carboxy- and carbamoyltransferases
                2.1.3.11 N-succinylornithine carbamoyltransferase

Engineering

Engineering on EC 2.1.3.11 - N-succinylornithine carbamoyltransferase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
P90E
-
conversion of N-succinly-L-ornithine carbamoyltransferase to N-acetyl-L-ornithine carbamoyltransferase
P90E/T242L
contrary to wild-type, mutant accepts N-acetyl-L-ornithine as a substrate. Decrease in Km value for N-succinyl-L-ornithine
T242L
slight decrease in Km value
E92A
-
site-directed mutagenesi of N-acetyl-L-ornithine carbamoyltransferase, conversion to N-succinly-L-ornithine carbamoyltransferase
E92P
-
site-directed mutagenesi of N-acetyl-L-ornithine carbamoyltransferase, conversion to N-succinly-L-ornithine carbamoyltransferase
E92S
-
site-directed mutagenesi of N-acetyl-L-ornithine carbamoyltransferase, conversion to N-succinly-L-ornithine carbamoyltransferase
E92V
-
site-directed mutagenesi of N-acetyl-L-ornithine carbamoyltransferase, conversion to N-succinly-L-ornithine carbamoyltransferase