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2.1.3.10: malonyl-S-ACP:biotin-protein carboxyltransferase

This is an abbreviated version!
For detailed information about malonyl-S-ACP:biotin-protein carboxyltransferase, go to the full flat file.

Word Map on EC 2.1.3.10

Reaction

a malonyl-[acyl-carrier protein]
+
a biotinyl-[protein]
=
an acetyl-[acyl-carrier protein]
+
a carboxybiotinyl-[protein]

Synonyms

acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase, MadC,D, malonyl-S-acyl-carrier protein:biotin-protein carboxyltransferase, malonyl-[acyl-carrier protein]:biotinyl-[protein] carboxyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.3 Carboxy- and carbamoyltransferases
                2.1.3.10 malonyl-S-ACP:biotin-protein carboxyltransferase

Systematic Name

Systematic Name on EC 2.1.3.10 - malonyl-S-ACP:biotin-protein carboxyltransferase

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SYSTEMATIC NAME
IUBMB Comments
malonyl-[acyl-carrier protein]:biotinyl-[protein] carboxytransferase
Derived from the components MadC and MadD of the anaerobic bacterium Malonomonas rubra, this enzyme is a component of EC 7.2.4.4, biotin-dependent malonate decarboxylase. The carboxy group is transferred from malonate to the prosthetic group of the biotin protein (MadF) with retention of configuration [2]. Similar to EC 4.1.1.87, malonyl-S-ACP decarboxylase, which forms part of the biotin-independent malonate decarboxylase (EC 4.1.1.88), this enzyme also follows on from EC 2.3.1.187, acetyl-S-ACP:malonate ACP transferase, and results in the regeneration of the acetyl-[acyl-carrier protein] [3].