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2.1.3.1: methylmalonyl-CoA carboxytransferase

This is an abbreviated version!
For detailed information about methylmalonyl-CoA carboxytransferase, go to the full flat file.

Word Map on EC 2.1.3.1

Reaction

(S)-methylmalonyl-CoA
+
pyruvate
=
propanoyl-CoA
+
oxaloacetate

Synonyms

5S subunit of transcarboxylase, carboxyltransferase subunit of acetyl-CoA carboxylase, carboxyltransferase, methylmalonyl coenzyme A, DtsR1, MCT, methyl malonyl CoA carboxyl transferase, methylmalonyl CoA carboxyltransferase, methylmalonyl CoA-oxalacetate transcarboxylase, methylmalonyl coenzyme A carboxyltransferase, methylmalonyl-CoA carboxyltransferase, methylmalonyl-CoA transcarboxylase, MMC, oxalacetic transcarboxylase, transcarboxylase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.3 Carboxy- and carbamoyltransferases
                2.1.3.1 methylmalonyl-CoA carboxytransferase

pH Stability

pH Stability on EC 2.1.3.1 - methylmalonyl-CoA carboxytransferase

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pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.5
-
26S-form stable
485819, 485820
6.5
-
stable, at pH 8 enzyme dissociates
485818
8
-
dilute solution, 50 mM buffer, 25°C: enzyme dissociates into subunits and rapidly loses activity, Co2+ protects, Zn2+ protects slightly
485820
9
-
enzyme dissociates into 12SH, 5SE, 6SE and 6SH subunits, in the presence of Co2+: the 6SE subunits binds to 12SH subunit
485820
additional information
-
effect of pH on the overall conformation of the 1.3 subunit, below 3.5 and above 9.0: the N-terminus of the 1.3S protein undergoes a transition into a random coil or unordered conformation
485825