2.1.2.9: methionyl-tRNA formyltransferase

This is an abbreviated version!
For detailed information about methionyl-tRNA formyltransferase, go to the full flat file.

Word Map on EC 2.1.2.9

2.1.2.9

formylation

leigh

methionylated

eubacteria

met-trnafmet

anticodon

met-trnas

deformylase

glycinamide

n10-formyltetrahydrofolate

Reaction

Synonyms

FMT, FMT1, Fmt1p, formyl-methionyl transferase, formylmethionyl-transfer ribonucleic synthetase, methionyl ribonucleic formyltransferase, methionyl-transfer ribonucleic transformylase, methionyl-transfer RNA transformylase, methionyl-tRNA formyltransferase, methionyl-tRNA Met formyltransferase, methionyl-tRNA transformylase, methionyl-tRNA-Formyltransferase, methyltransferase, methionyl-transfer ribonucleate, mitochondrial methionyl-tRNA formyltransferase, MTF, MTFMT, N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.2 Hydroxymethyl-, formyl- and related transferases

2.1.2.9 methionyl-tRNA formyltransferase

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Results	in table
2	Activating Compound
46946	AA Sequence
1	CAS Registry Number
14	Cloned(Commentary)
29	Cofactor
7	Crystallization (Commentary)
77	Disease/ Diagnostics
18	General Information
3	General Stability
17	Inhibitors
5	Ki Value [mM]
57	KM Value [mM]
27	Localization
27	Metals/Ions
11	Molecular Weight [Da]
44	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
337	Organism
3	Pathway
18	PDB ID
5	pH Optimum
3	pH Range
71	Protein Variants
18	Purification (Commentary)
1	Reaction
1	Reaction Type
58	Reference
5	Source Tissue
12	Specific Activity [micromol/min/mg]
8	Storage Stability
239	Substrates and Products (Substrate)
5	Subunits
33	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
32	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 2.1.2.9 - methionyl-tRNA formyltransferase

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10-Formylaminopterin

Euglena gracilis

0.01 mM: 38% inhibition, 0.1 mM: 62% inhibition, competitive

485801

10-formylpteroylglutamic acid

Euglena gracilis

0.1 mM: 31% inhibition, 1 mM: 52% inhibition, competitive

485801

5,10-methylenetetrahydrofolate

Euglena gracilis

485801

5-formyltetrahydrofolate

Euglena gracilis

competitive inhibition

485801

5-methyltetrahydrofolate

Euglena gracilis

most effective, non-competitive inhibitor

485801

aminopterin

Euglena gracilis

1 mM: 26% inhibition, competitive inhibition

485801

methotrexate

Euglena gracilis

0.01 mM: 30% inhibition, 0.1 mM, 52% inhibition, competitive

485801

reduced aminopterin

Euglena gracilis

1 mM, 34% inhibition, competitive inhibition

485801

SB-734453

Staphylococcus aureus

735441

tetrahydrofolate

2 entries

tRNAfMet

2 entries

additional information

3 entries