2.1.2.8: deoxycytidylate 5-hydroxymethyltransferase

This is an abbreviated version!
For detailed information about deoxycytidylate 5-hydroxymethyltransferase, go to the full flat file.

Reaction

Synonyms

d-cytidine 5'-monophosphate hydroxymethylase, DCH, dCMP Hmase, dCMP hydroxymethylase, deoxyCMP hydroxymethylase, deoxycytidylate hydroxymethylase, deoxycytidylate hydroxymethyltransferase, deoxycytidylic hydroxymethylase, hydroxymethyltransferase, deoxycytidylate

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.2 Hydroxymethyl-, formyl- and related transferases

                2.1.2.8 deoxycytidylate 5-hydroxymethyltransferase

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Results	in table
1	Activating Compound
39	AA Sequence
1	CAS Registry Number
14	Cloned(Commentary)
33	Cofactor
2	Crystallization (Commentary)
13	Inhibitors
8	Ki Value [mM]
2	KM Value [mM]
1	Localization
17	Molecular Weight [Da]
19	Natural Substrates/ Products (Substrates)
18	Organism
3	Pathway
9	PDB ID
1	pH Optimum
17	Protein Variants
11	Purification (Commentary)
7	Reaction
1	Reaction Type
18	Reference
7	Specific Activity [micromol/min/mg]
3	Storage Stability
37	Substrates and Products (Substrate)
8	Subunits
14	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Stability [°C]
5	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.1.2.8 - deoxycytidylate 5-hydroxymethyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

5,10-methylenetetrahydrofolate + H2O + dCMP

tetrahydrofolate + 5-hydroxymethyl-dCMP

Tequatrovirus T4

P08773

-

757025

-

-

?

5,10-methylenetetrahydrofolate + H2O + deoxycytidylate

tetrahydrofolate + 5-hydroxymethyldeoxycytidylate

11 entries

additional information

?

-

7 entries

5,10-methylenetetrahydrofolate + H2O + deoxycytidylate

tetrahydrofolate + 5-hydroxymethyldeoxycytidylate

Tequatrovirus

-

the hydroxymethylation is catalyzed by dCMP hydroxymethylase, which transfers a methylene group from methylenetetrahydrofolate to C5 of dCMP and then uses a water molecule to hydrate the methylene group to form hydroxymethyl-dCMP, one precursor for phage DNA replication

735967

-

-

?

5,10-methylenetetrahydrofolate + H2O + deoxycytidylate

tetrahydrofolate + 5-hydroxymethyldeoxycytidylate

Tequatrovirus T4

-

-

485787

enzyme is responsible for production of 5-hydroxymethyl-dCMP found in the DNA of the phage

485787

?

5,10-methylenetetrahydrofolate + H2O + deoxycytidylate

tetrahydrofolate + 5-hydroxymethyldeoxycytidylate

Tequatrovirus T4

-

-

485788

enzyme is responsible for production of 5-hydroxymethyl-dCMP found in the DNA of the phage

485788

?

5,10-methylenetetrahydrofolate + H2O + deoxycytidylate

tetrahydrofolate + 5-hydroxymethyldeoxycytidylate

Tequatrovirus T4

P08773

-

485792

enzyme forms part of phage DNA protection system

485792

?

5,10-methylenetetrahydrofolate + H2O + deoxycytidylate

tetrahydrofolate + 5-hydroxymethyldeoxycytidylate

Tequatrovirus T4

-

-

485789

5-hydroxymethyl-dCMP is essential for DNA synthesis in phage T4

485789

?

5,10-methylenetetrahydrofolate + H2O + deoxycytidylate

tetrahydrofolate + 5-hydroxymethyldeoxycytidylate

Tequatrovirus T4

-

-

485790

5-hydroxymethyl-dCMP is essential for DNA synthesis in phage T4

485790

?

5,10-methylenetetrahydrofolate + H2O + deoxycytidylate

tetrahydrofolate + 5-hydroxymethyldeoxycytidylate

Tequatrovirus T4

P08773

-

485792

5-hydroxymethyl-dCMP is essential for DNA synthesis in phage T4

485792

?

5,10-methylenetetrahydrofolate + H2O + deoxycytidylate

tetrahydrofolate + 5-hydroxymethyldeoxycytidylate

Tequatrovirus T4

-

-

485786

5-hydroxymethyl-dCMP is a virus-specific DNA precursor

485786

?

5,10-methylenetetrahydrofolate + H2O + deoxycytidylate

tetrahydrofolate + 5-hydroxymethyldeoxycytidylate

Tequatrovirus T4

-

-

485791

involved in biosynthesis of DNA precursor

485791

?

5,10-methylenetetrahydrofolate + H2O + deoxycytidylate

tetrahydrofolate + 5-hydroxymethyldeoxycytidylate

Tequatrovirus T4

P08773

-

485792

involved in biosynthesis of DNA precursor

485792

?

5,10-methylenetetrahydrofolate + H2O + deoxycytidylate

tetrahydrofolate + 5-hydroxymethyldeoxycytidylate

Tequatrovirus T4

-

dCTP depresses the synthesis of 5-hydroxymethyldeoxycytidylate

209854

-

209854

?

additional information

?

-

bacteriophage T6r+

-

biosynthesis of enzyme de novo after infection

485780

-

-

?

additional information

?

-

Escherichia coli

-

direct interaction between NDP kinase and dCMP hydroxymethylase

659367

-

-

?

additional information

?

-

Tequatrovirus T4

-

enzyme is part of the dNTP synthetase complex

485788

-

-

?

additional information

?

-

Tequatrovirus T4

P08773

enzyme functions in vivo as a component of a multienzyme complex called dNTP synthetase

485792

-

-

?

additional information

?

-

Tequatrovirus T4

-

enzyme is part of a complex efficiently channeling DNA precursors to the replication apparatus

209854

-

-

?

additional information

?

-

Tequatrovirus T4

P08773

enzyme is part of a complex efficiently channeling DNA precursors to the replication apparatus

485792

-

-

?

additional information

?

-

Tequatrovirus T4

-

enzyme is part of a complex catalyzing DNA precursor biosynthesis

485786

-

-

?