2.1.2.8: deoxycytidylate 5-hydroxymethyltransferase

This is an abbreviated version!
For detailed information about deoxycytidylate 5-hydroxymethyltransferase, go to the full flat file.

Word Map on EC 2.1.2.8

2.1.2.8

bacteriophage

phage

thymidylate

amber

deoxyribonucleotide

triphosphate

dtmp

dihydrofolate

phage-coded

cytosine

ribonucleotide

fork

t4-infected

dctpase

Reaction

Synonyms

d-cytidine 5'-monophosphate hydroxymethylase, DCH, dCMP Hmase, dCMP hydroxymethylase, deoxyCMP hydroxymethylase, deoxycytidylate hydroxymethylase, deoxycytidylate hydroxymethyltransferase, deoxycytidylic hydroxymethylase, hydroxymethyltransferase, deoxycytidylate

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.2 Hydroxymethyl-, formyl- and related transferases

2.1.2.8 deoxycytidylate 5-hydroxymethyltransferase

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Results	in table
1	Activating Compound
39	AA Sequence
1	CAS Registry Number
14	Cloned(Commentary)
33	Cofactor
2	Crystallization (Commentary)
13	Inhibitors
8	Ki Value [mM]
2	KM Value [mM]
1	Localization
17	Molecular Weight [Da]
19	Natural Substrates/ Products (Substrates)
18	Organism
3	Pathway
9	PDB ID
1	pH Optimum
17	Protein Variants
11	Purification (Commentary)
7	Reaction
1	Reaction Type
18	Reference
7	Specific Activity [micromol/min/mg]
3	Storage Stability
37	Substrates and Products (Substrate)
8	Subunits
14	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Stability [°C]
5	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 2.1.2.8 - deoxycytidylate 5-hydroxymethyltransferase

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10-methyl-5,8-dideazatetrahydrofolate

Tequatrovirus T4

competitive inhibitor with respect to tetrahydrofolate

485790

5,5'-dithiobis(2-nitrobenzoic acid)

Tequatrovirus T4

complete loss of activity, second-order kinetics, inactivation is reversed by dithiothreitol, inactivation involves the modification of one thiol group per mol of dimeric enzyme

485785

5-deazatetrahydrofolate

2 entries

5-Fluoro-2'-deoxycytidine 5'-monophosphate

Tequatrovirus T4

competitive inhibitor with respect to dCMP, not mechanism-based inhibitor

485787

5-fluorodeoxyuridylate

3 entries

5-hydroxymethyl-dCMP

Tequatrovirus T4

competitor of dCMP, inhibits formation of 5-hydroxymethyl-dCMP

485790

aminopterin

Tequatrovirus T4

competitive inhibitor with respect to tetrahydrofolate

485785

dihydrofolate

Tequatrovirus T4

competitive inhibitor with respect to tetrahydrofolate

485785

methotrexate

Tequatrovirus T4

competitive inhibitor with respect to tetrahydrofolate

485785

N-ethylmaleimide

Tequatrovirus T4

complete loss of activity, second-order kinetics, pH-dependent inactivation, dCMP protects against inactivation, dCMP plus either methotrexate or aminopterin greatly enhances protection, inactivation involves the modification of one thiol group per mol of dimeric enzyme

485785