2.1.2.5: glutamate formimidoyltransferase
This is an abbreviated version!
For detailed information about glutamate formimidoyltransferase, go to the full flat file.
Word Map on EC 2.1.2.5
-
2.1.2.5
-
octameric
-
megaloblastic
-
aciduria
-
formylation
-
folinic
-
polyglutamate
-
figlu
-
monofunctional
-
polyglutamylated
-
methylenetetrahydrofolate
-
histidase
-
medicine
-
molecular biology
- 2.1.2.5
-
octameric
-
megaloblastic
-
aciduria
-
formylation
-
folinic
- polyglutamate
-
figlu
-
monofunctional
-
polyglutamylated
- methylenetetrahydrofolate
- histidase
- medicine
- molecular biology
Reaction
Synonyms
EC 2.1.2.6, formiminoglutamic acid formiminotransferase, formiminoglutamic acid transferase, formiminoglutamic formiminotransferase, formiminotransferase cyclodeaminase, formiminotransferase, glutamate, formiminotransferase-cyclodeaminase, FTCD, glutamate formiminotransferase, glutamate formyltransferase
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Reference on EC 2.1.2.5 - glutamate formimidoyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Slavik, K.; Zizkovsky, V.; Slavikova, V.; Fort, P.
The purification of formiminotransferase and cyclodeaminase by combination of affinity chromatography and isoelectric focusing
Biochem. Biophys. Res. Commun.
59
1173-1184
1974
Sus scrofa
Hennig, D.; Scales, S.J.; Moreau, A.; Murley, L.L.; De Mey, J.; Kreis, T.E.
A formiminotransferase cyclodeaminase isoform is localized to the Golgi complex and can mediate interaction of trans-Golgi network-derived vesicles with microtubules
J. Biol. Chem.
273
19602-19611
1998
Meleagris gallopavo, Gallus gallus (Q9YH58)
Gao, Y.S.; Alvarez, C.; Nelson, D.S.; Sztul, E.
Molecular cloning, characterization, and dynamics of rat formiminotransferase cyclodeaminase, a Golgi-associated 58-kDa protein
J. Biol. Chem.
273
33825-33834
1998
Rattus norvegicus
Tabor, H.; Wyngarden, L.
The enzymatic formation of formiminotetrahydrofolic acid, 5,10-methenyltetrahydrofolic acid, and 10-formyltetrahydrofolic acid in the metabolism of formiminoglutamic acid
J. Biol. Chem.
234
1830-1846
1959
Bos taurus, Cavia porcellus, Oryctolagus cuniculus, Felis catus, Homo sapiens, Mus musculus, Sus scrofa
Miller, A.; Waelsch, H.
Formimino transfer from formamidinoglutaric acid to tetrahydrofolic acid
J. Biol. Chem.
228
397-417
1957
Bos taurus, Rattus norvegicus
Silverman, M.; Keresztesy, J.C.; Koval, G.J.; Gardiner, R.C.
Citrovorum factor and the synthesis of formylglutamic acid
J. Biol. Chem.
226
83-94
1957
Sus scrofa
Beaudet, R.; Mackenzie, R.
Kinetic mechanism of formininotransferase from porcine liver
Biochim. Biophys. Acta
410
252-261
1975
Sus scrofa
Murley, L.L.; Mejia, N.R.; MacKenzie, R.E.
The nucleotide sequence of porcine formiminotransferase cyclodeaminase. Expression and purification from Escherichia coli
J. Biol. Chem.
268
22820-22824
1993
Sus scrofa (P53603)
Bashour, A.M.; Bloom, G.S.
58K, a microtubule-binding Golgi protein, is a formiminotransferase cyclodeaminase
J. Biol. Chem.
273
19612-19617
1998
Rattus norvegicus
Murley, L.L.; MacKenzie, R.E.
The two monofunctional domains of octameric formiminotransferase-cyclodeaminase exist as dimers
Biochemistry
34
10358-10364
1995
Sus scrofa
Kohls, D.; Sulea, T.; Purisima, E.O.; MacKenzie, R.E.; Vrielink, A.
The crystal structure of the formiminotransferase domain of formiminotransferase-cyclodeaminase: Implications for substrate channeling in a bifunctional enzyme
Structure
8
35-46
2000
Sus scrofa
Murley, L.L.; MacKenzie, R.E.
Monofunctional domains of formiminotransferase-cyclodeaminase retain similar conformational stabilities outside the bifunctional octamer
Biochim. Biophys. Acta
1338
223-232
1997
Sus scrofa
Renous, R.; Lapierre, P.; Djilali-Saiah, I.; Vitozzi, S.; Alvarez, F.
Characterization of the antigenicity of the formiminotransferase-cyclodeaminase in type 2 autoimmune hepatitis
Exp. Cell Res.
292
332-341
2004
Homo sapiens (O95954), Homo sapiens
Mao, Y.; Vyas, N.K.; Vyas, M.N.; Chen, D.H.; Ludtke, S.J.; Chiu, W.; Quiocho, F.A.
Structure of the bifunctional and Golgi-associated formiminotransferase cyclodeaminase octamer
EMBO J.
23
2963-2971
2004
Rattus norvegicus (O88618)
Hilton, J.F.; Christensen, K.E.; Watkins, D.; Raby, B.A.; Renaud, Y.; de la Luna, S.; Estivill, X.; MacKenzie, R.E.; Hudson, T.J.; Rosenblatt, D.S.
The molecular basis of glutamate formiminotransferase deficiency
Hum. Mutat.
22
67-73
2003
Homo sapiens, Sus scrofa
Hagiwara, H.; Tajika, Y.; Matsuzaki, T.; Suzuki, T.; Aoki, T.; Takata, K.
Localization of Golgi 58K protein (formiminotransferase cyclodeaminase) to the centrosome
Histochem. Cell Biol.
126
251-259
2006
Homo sapiens (O05954)
Jeanguenin, L.; Lara-Nunez, A.; Pribat, A.; Mageroy, M.H.; Gregory, J.F.; Rice, K.C.; de Crecy-Lagard, V.; Hanson, A.D.
Moonlighting glutamate formiminotransferases can functionally replace 5-formyltetrahydrofolate cycloligase
J. Biol. Chem.
285
41557-41566
2010
Streptococcus pyogenes, Thermoplasma acidophilum, Picrophilus torridus, Candidatus Koribacter versatilis, no activity in Herpetosiphon aurantiacus, Candidatus Koribacter versatilis Ellin345, Streptococcus pyogenes M1
Majumdar, R.; Yori, A.; Rush, P.W.; Raymond, K.; Gavrilov, D.; Tortorelli, S.; Matern, D.; Rinaldo, P.; Feldman, G.L.; Oglesbee, D.
Allelic spectrum of formiminotransferase-cyclodeaminase gene variants in individuals with formiminoglutamic aciduria
Mol. Genet. Genomic Med.
5
795-799
2017
Homo sapiens
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