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2.1.2.5: glutamate formimidoyltransferase

This is an abbreviated version!
For detailed information about glutamate formimidoyltransferase, go to the full flat file.

Word Map on EC 2.1.2.5

Reaction

5-formimidoyltetrahydrofolate
+
L-glutamate
=
tetrahydrofolate
 +
N-formimidoyl-L-glutamate

Synonyms

EC 2.1.2.6, formiminoglutamic acid formiminotransferase, formiminoglutamic acid transferase, formiminoglutamic formiminotransferase, formiminotransferase cyclodeaminase, formiminotransferase, glutamate, formiminotransferase-cyclodeaminase, FTCD, glutamate formiminotransferase, glutamate formyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.2 Hydroxymethyl-, formyl- and related transferases
                2.1.2.5 glutamate formimidoyltransferase

Inhibitors

Inhibitors on EC 2.1.2.5 - glutamate formimidoyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
acetate
-
inhibition in decreasing order: fumarate, succinate, citrate, acetate
acetyl-L-glutamate
-
0.015 mM, 30% inhibition
aminopterin
-
0.0005 mM, 53% inhibition
arsenate
-
weak
barium acetate
-
0.1 M, 90% inhibition
Ca2+
-
0.1 M, strong inhibition in decreasing order: La3+, Ca2+, Mg2+, Li+, Na+, K+
CaCl2
-
0.1 M, 72% inhibition
citrate
D-glutamate
-
0.015 mM, 47% inhibition
folic acid
formyl-L-glutamate
-
0.015 mM, 53% inhibition
fumarate
-
inhibition in decreasing order: fumarate, succinate, citrate, acetate
imidazole
-
-
K+
-
0.1 M, strong inhibition in decreasing order: La3+, Ca2+, Mg2+, Li+, Na+, K+
K2SO4
-
0.1 M, 30% inhibition
KNO3
-
0.1 M, 65% inhibition
L-aspartate
-
0.015 mM, 26% inhibition
L-glutamate
La3+
-
0.1 M, strong inhibition in decreasing order: La3+, Ca2+, Mg2+, Li+, Na+, K+
Li+
-
0.1 M, strong inhibition in decreasing order: La3+, Ca2+, Mg2+, Li+, Na+, K+
Maleate
-
-
methotrexate
-
0.0005 mM: 33% inhibition, 0.001 mM: 83% inhibition
Mg2+
-
0.1 M, strong inhibition in decreasing order: La3+, Ca2+, Mg2+, Li+, Na+, K+
MnCl2
-
0.1 M: 98% inhibition, 0.01 M: 65% inhibition
N-formiminoaspartate
-
-
Na+
-
0.1 M, strong inhibition in decreasing order: La3+, Ca2+, Mg2+, Li+, Na+, K+
NH4Cl
-
high concentrations
p-acetylaminobenzoylglutamate
-
0.3 mM, 50% inhibition
p-aminobenzoylglutamate
-
2.5 mM, 50% inhibition
p-formylaminobenzoylglutamate
-
0.3 mM, 50% inhibition
p-iodobenzoylglutamate
-
1.5 mM, 50% inhibition
phosphate
-
weak
proteinase K
-
degradation of bifunctional formiminotransferase cyclodeaminase
-
succinate
-
inhibition in decreasing order: fumarate, succinate, citrate, acetate
Tris
-
-
ZnCl2
-
0.01 M, 99% inhibition
additional information
-
not inhibited by formamidinoacetic acid, gamma-benzyl-formamidinoglutaric acid, formic acid, formamide, formylglutamine, formylisoglutamine
-