2.1.1.B84: cephaline 6'-O-methyltransferase
This is an abbreviated version!
For detailed information about cephaline 6'-O-methyltransferase, go to the full flat file.
Reaction
Synonyms
CiOMT1, IpeOMT1
ECTree
2.1.1.B84 cephaline 6'-O-methyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.1.1.B84 - cephaline 6'-O-methyltransferase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + (R)-norprotosinomenine
S-adenosyl-L-homocysteine + ?
-
-
-
?
S-adenosyl-L-methionine + (R,S)-isococlaurine
S-adenosyl-L-homocysteine + ?
-
-
-
?
S-adenosyl-L-methionine + (R,S)-isoorientaline
S-adenosyl-L-homocysteine + ?
-
-
-
?
S-adenosyl-L-methionine + (R,S)-norcoclaurine
S-adenosyl-L-homocysteine + ?
-
-
-
?
S-adenosyl-L-methionine + (R,S)-protosinomenine
S-adenosyl-L-homocysteine + ?
-
-
-
?
S-adenosyl-L-methionine + (S)-4'-O-methyllaudanosoline
S-adenosyl-L-homocysteine + ?
-
-
-
?
S-adenosyl-L-methionine + (S)-norprotosinomenine
S-adenosyl-L-homocysteine + ?
-
-
-
?
S-adenosyl-L-methionine + 1alpha-(S)-N-deacetylisoipecoside
S-adenosyl-L-homocysteine + 6-O-methyl-N-deacetylisoipecoside
S-adenosyl-L-methionine + 7-O-methyl-N-deacetylisoipecoside
S-adenosyl-L-homocysteine + 6,7-O,O-dimethyl-N-deacetylisoipecoside
-
-
-
?
S-adenosyl-L-methionine + N-deacetylisoipecoside
S-adenosyl-L-homocysteine + 6-O-methyl-N-deacetylipecoside
-
-
-
?
S-adenosyl-L-methionine + 1alpha-(S)-N-deacetylisoipecoside
S-adenosyl-L-homocysteine + 6-O-methyl-N-deacetylisoipecoside
-
-
-
-
?
S-adenosyl-L-methionine + 1alpha-(S)-N-deacetylisoipecoside
S-adenosyl-L-homocysteine + 6-O-methyl-N-deacetylisoipecoside
-
the iminium cation, one of the spontaneous reaction products of 6-O-methyl-N-deacetylisoipecoside aglycon, might be an intermediate of emetine biosynthesis
-
-
?
S-adenosyl-L-methionine + cephaeline
S-adenosyl-L-homocysteine + emetine
-
-
-
?
S-adenosyl-L-methionine + cephaeline
S-adenosyl-L-homocysteine + emetine
-
-
-
-
?
S-adenosyl-L-methionine + cephaeline
S-adenosyl-L-homocysteine + emetine
the enzyme is involved in emetine biosynthesis. It does not catalyze the 7'-O-methylation of 7'-O-demethylcephaeline, the preceding step in the biosynthesis of emetine
-
-
?
S-adenosyl-L-methionine + cephaeline
S-adenosyl-L-homocysteine + emetine
6'-O-methylation
-
-
?
additional information
?
-
IpeOMT1 does not catalyze the 7'-O-methylation of 7'-O-demethylcephaeline. IpeOMT1 shows broad substrate specificity towards the intermediates in emetine biosynthesis. IpeOMT1 dominantly catalyzes 6-O-methylation of the 6,7-dihydroxy- and 6-hydroxy-7-methoxyisoquinolines. The regional substrate specificity at the last step of emetine biosynthesis is restricted to 6'-O-methylation
-
-
?
additional information
?
-
-
IpeOMT1 does not catalyze the 7'-O-methylation of 7'-O-demethylcephaeline. IpeOMT1 shows broad substrate specificity towards the intermediates in emetine biosynthesis. IpeOMT1 dominantly catalyzes 6-O-methylation of the 6,7-dihydroxy- and 6-hydroxy-7-methoxyisoquinolines. The regional substrate specificity at the last step of emetine biosynthesis is restricted to 6'-O-methylation
-
-
?
additional information
?
-
the enzyme is also active on 7'-O-demethylcephaeline forming cephaeline, overview
-
-
?
additional information
?
-
substrate specificity of CiOMT2, overview
-
-
?
