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2.1.1.B43: tRNA (cytosine49-C5)-methyltransferase

This is an abbreviated version!
For detailed information about tRNA (cytosine49-C5)-methyltransferase, go to the full flat file.

Reaction

S-adenosyl-L-methionine
+
cytosine49 in tRNA
=
S-adenosyl-L-homocysteine
+
5-methylcytosine49 in tRNA

Synonyms

PAB1946

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.B43 tRNA (cytosine49-C5)-methyltransferase

Activating Compound

Activating Compound on EC 2.1.1.B43 - tRNA (cytosine49-C5)-methyltransferase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
archaease
in vitro, the purified recombinant methyltransferase catalyzes 5-methylcytosine formation at several cytosines within tRNAs with preference for C49. The specificity of the methyltransferase is increased by the archease. In solution, the archease exists as a monomer, trimer, and hexamer. Only the oligomeric states bind the methyltransferase and prevent its aggregation, in addition to hindering dimerization of the methyltransferase-tRNA complex
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