2.1.1.B3: sialate-8-O-methyltransferase

This is an abbreviated version!
For detailed information about sialate-8-O-methyltransferase, go to the full flat file.

Reaction

Synonyms

S-adenosyl-L-methionine: sialate-8-O-methyltransferase, sialate-8-O-methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.B3 sialate-8-O-methyltransferase

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Results	in table
5	Inhibitors
3	KM Value [mM]
1	Localization
4	Metals/Ions
2	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
1	Organism
1	pH Optimum
1	Purification (Commentary)
1	Reaction
1	Reference
1	Source Tissue
1	Specific Activity [micromol/min/mg]
9	Substrates and Products (Substrate)
1	Subunits
2	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 2.1.1.B3 - sialate-8-O-methyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

S-adenosyl-L-methionine + CMP-N-acetylneuraminic acid

S-adenosyl-L-homocysteine + CMP-N-acetyl-8-O-methyl-neuraminate

Asterias rubens

-

-

673429

-

-

?

S-adenosyl-L-methionine + colominic acid

?

Asterias rubens

-

-

673429

-

-

?

S-adenosyl-L-methionine + fetuin

?

Asterias rubens

-

-

673429

-

-

?

S-adenosyl-L-methionine + N-acetylneuraminic acid

S-adenosyl-L-homocysteine + N-acetyl-8-O-methyl-neuraminate

2 entries

S-adenosyl-L-methionine + N-acetylneuraminyl alpha2,3-lactose

S-adenosyl-L-homocysteine + N-acetyl-8-O-methyl-neuraminyl alpha2,3-lactose

Asterias rubens

-

free N-acetylneuraminyl alpha2,3-lactose and oligosaccharide- or glycoprotein-bound substrate, the latter is preferred

673429

-

-

?

S-adenosyl-L-methionine + N-acetylneuraminyl alpha2,6-lactose

S-adenosyl-L-homocysteine + N-acetyl-8-O-methyl-neuraminyl alpha2,6-lactose

Asterias rubens

-

free N-acetylneuraminyl alpha2,6-lactose acid and oligosaccharide- or glycoprotein-bound substrate, the latter is preferred

673429

-

-

?

S-adenosyl-L-methionine + N-glycoloylneuraminic acid

S-adenosyl-L-homocysteine + N-glycoloyl-8-O-methyl-neuraminate

Asterias rubens

-

free N-glycoloylneuraminic acid and oligosaccharide- or glycoprotein-bound substrate, the latter is preferred

673429

-

-

?

additional information

?

-

Asterias rubens

-

the enzyme preforms specific methylation of endogenous and exogenous glycoconjugate-bound sialic acids, usage of desialized human erythrocyte membranes as substrates, methylation of resialylated erythrocyte membranes, overview

673429

-

-

?

S-adenosyl-L-methionine + N-acetylneuraminic acid

S-adenosyl-L-homocysteine + N-acetyl-8-O-methyl-neuraminate

Asterias rubens

-

-

673429

-

-

?

S-adenosyl-L-methionine + N-acetylneuraminic acid

S-adenosyl-L-homocysteine + N-acetyl-8-O-methyl-neuraminate

Asterias rubens

-

free N-acetylneuraminic acid and oligosaccharide- or glycoprotein-bound substrate, the latter is preferred

673429

NMR product identification

-

?