2.1.1.99: 3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase

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For detailed information about 3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase, go to the full flat file.

Reaction

Synonyms

16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase, methyltransferase, 16-methoxy-2,3-dihydro-3-hydroxytabersonine, NMT, S-adenosyl-L-methionine:16-methoxy-2,3-dihydro-3-hydroxy-tabersonine N-methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.99 3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase

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Results	in table
1	Activating Compound
1	AA Sequence
1	CAS Registry Number
1	General Stability
1	Inhibitors
2	Localization
1	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
4	Organic Solvent Stability
3	Organism
1	Oxidation Stability
3	Pathway
1	Purification (Commentary)
3	Reaction
1	Reaction Type
3	Reference
2	Source Tissue
1	Specific Activity [micromol/min/mg]
3	Storage Stability
7	Substrates and Products (Substrate)
4	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 2.1.1.99 - 3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

S-adenosyl-L-methionine + 16-methoxy-2,3-dihydro-3-hydroxytabersonine

S-adenosyl-L-homocysteine + deacetoxyvindoline

6 entries

additional information

?

-

Catharanthus roseus

-

hydrogenation of 2,3 double bond of tabersonine instead of hydration results in a 75% decrease in N-methylation, double bound present: no N-methylation, the presence of 6,7 double bound is a necessary structural requirement for N-methylation with membrane-bound enzyme, whereas the detergent-solubilized enzyme is also able to N-methylate the 6,7 anhydro analogue

485692

-

-

?

S-adenosyl-L-methionine + 16-methoxy-2,3-dihydro-3-hydroxytabersonine

S-adenosyl-L-homocysteine + deacetoxyvindoline

Catharanthus roseus

-

-

485690

i.e. N(1)-methyl-16-methoxy-2,3-dihydro-3-hydroxytabersonine

485690

?

S-adenosyl-L-methionine + 16-methoxy-2,3-dihydro-3-hydroxytabersonine

S-adenosyl-L-homocysteine + deacetoxyvindoline

Catharanthus roseus

-

-

485691

i.e. N(1)-methyl-16-methoxy-2,3-dihydro-3-hydroxytabersonine

485691

?

S-adenosyl-L-methionine + 16-methoxy-2,3-dihydro-3-hydroxytabersonine

S-adenosyl-L-homocysteine + deacetoxyvindoline

Catharanthus roseus

-

high degree of specificity for the N-indole of 2,3-dihydro-3-hydroxytabersonine

485692

-

-

?

S-adenosyl-L-methionine + 16-methoxy-2,3-dihydro-3-hydroxytabersonine

S-adenosyl-L-homocysteine + deacetoxyvindoline

Catharanthus roseus

-

enzyme is involved in the biosynthesis of vindoline from tabersonine

485690

-

485690

?

S-adenosyl-L-methionine + 16-methoxy-2,3-dihydro-3-hydroxytabersonine

S-adenosyl-L-homocysteine + deacetoxyvindoline

Catharanthus roseus

-

enzyme is involved in the biosynthesis of vindoline from tabersonine

485691

-

485691

?

S-adenosyl-L-methionine + 16-methoxy-2,3-dihydro-3-hydroxytabersonine

S-adenosyl-L-homocysteine + deacetoxyvindoline

Catharanthus roseus

-

enzyme is involved in the biosynthesis of vindoline from tabersonine

485692

-

-

?