2.1.1.8: histamine N-methyltransferase

This is an abbreviated version!
For detailed information about histamine N-methyltransferase, go to the full flat file.

Reaction

Synonyms

histamine 1-methyltransferase, histamine methyltransferase, histamine N-methyltransferase, histamine-methylating enzyme, histamine-N-methyltransferase, HMT, HNMT, imidazole methyltransferase, imidazole N-methyltransferase, imidazolemethyltransferase, methyltransferase, histamine, Ntau-methyltransferase, S-adenosylmethionine-histamine N-methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.8 histamine N-methyltransferase

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Results	in table
8	Activating Compound
280	AA Sequence
10	Application
1	CAS Registry Number
6	Cloned(Commentary)
1	Crystallization (Commentary)
299	Disease/ Diagnostics
1	Expression
1	General Information
1	General Stability
114	Inhibitors
7	Ki Value [mM]
29	KM Value [mM]
5	Localization
11	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
66	Organism
3	Pathway
12	PDB ID
15	pH Optimum
2	pH Range
17	Protein Variants
16	Purification (Commentary)
5	Reaction
2	Reaction Type
66	Reference
138	Source Tissue
21	Specific Activity [micromol/min/mg]
5	Storage Stability
51	Substrates and Products (Substrate)
13	Subunits
37	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
7	Temperature Stability [°C]
4	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.1.1.8 - histamine N-methyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

S-adenosyl-L-methionine + (+/-)beta-methylhistamine

S-adenosyl-L-homocysteine + ?

Cavia porcellus

-

-

441571

-

-

?

S-adenosyl-L-methionine + (R)-alpha-methylhistamine

S-adenosyl-L-homocysteine + ?

2 entries

S-adenosyl-L-methionine + (S)-alpha-methylhistamine

S-adenosyl-L-homocysteine + ?

2 entries

S-adenosyl-L-methionine + BI 187004

S-adenosyl-L-homocysteine + 1-(1-methyl-1H-benzimidazole-6-carbonyl)-1,2,3,4,5,5a,10,10a-octahydroindeno[2,1-b]azepine-7-carbonitrile

Homo sapiens

P50135

BI 187004, i.e. an 11beta-hydroxysteroid dehydrogenase 1 inhibitor

756561

-

-

?

S-adenosyl-L-methionine + histamine

S-adenosyl-L-homocysteine + N-methylhistamine

2 entries

S-adenosyl-L-methionine + histamine

S-adenosyl-L-homocysteine + Ntau-methylhistamine

19 entries

S-adenosyl-L-methionine + homohistamine

S-adenosyl-L-homocysteine + ?

Cavia porcellus

-

-

441571

-

-

?

additional information

?

-

8 entries

S-adenosyl-L-methionine + (R)-alpha-methylhistamine

S-adenosyl-L-homocysteine + ?

Cavia porcellus

-

-

441571

-

-

?

S-adenosyl-L-methionine + (R)-alpha-methylhistamine

S-adenosyl-L-homocysteine + ?

Sus scrofa

-

-

441569

-

-

?

S-adenosyl-L-methionine + (S)-alpha-methylhistamine

S-adenosyl-L-homocysteine + ?

Cavia porcellus

-

-

441571

-

-

?

S-adenosyl-L-methionine + (S)-alpha-methylhistamine

S-adenosyl-L-homocysteine + ?

Sus scrofa

-

-

441569

-

-

?

S-adenosyl-L-methionine + histamine

S-adenosyl-L-homocysteine + N-methylhistamine

Cavia porcellus

-

-

686558

-

-

?

S-adenosyl-L-methionine + histamine

S-adenosyl-L-homocysteine + N-methylhistamine

Rattus norvegicus

-

-

686558

-

-

?

S-adenosyl-L-methionine + histamine

S-adenosyl-L-homocysteine + Ntau-methylhistamine

Bos taurus

-

-

441563

-

-

?

S-adenosyl-L-methionine + histamine

S-adenosyl-L-homocysteine + Ntau-methylhistamine

Bos taurus

-

highly specific for histamine

441567

-

-

?

S-adenosyl-L-methionine + histamine

S-adenosyl-L-homocysteine + Ntau-methylhistamine

Cavia porcellus

-

-

441556

-

441556

?

S-adenosyl-L-methionine + histamine

S-adenosyl-L-homocysteine + Ntau-methylhistamine

Cavia porcellus

-

-

441565, 441570, 441571, 441575

-

-

?

S-adenosyl-L-methionine + histamine

S-adenosyl-L-homocysteine + Ntau-methylhistamine

Cavia porcellus

-

highly specific for histamine

441557

-

441557

?

S-adenosyl-L-methionine + histamine

S-adenosyl-L-homocysteine + Ntau-methylhistamine

Cavia porcellus

-

highly specific for histamine

441573

-

-

?

S-adenosyl-L-methionine + histamine

S-adenosyl-L-homocysteine + Ntau-methylhistamine

Danio rerio

-

-

691489

-

-

?

S-adenosyl-L-methionine + histamine

S-adenosyl-L-homocysteine + Ntau-methylhistamine

Felis catus

-

-

441556

-

441556

?

S-adenosyl-L-methionine + histamine

S-adenosyl-L-homocysteine + Ntau-methylhistamine

Homo sapiens

-

-

441559, 441564, 701604, 703430

-

-

?

S-adenosyl-L-methionine + histamine

S-adenosyl-L-homocysteine + Ntau-methylhistamine

Homo sapiens

P50135

-

675356, 756090

-

-

?

S-adenosyl-L-methionine + histamine

S-adenosyl-L-homocysteine + Ntau-methylhistamine

Homo sapiens

-

-

756090

-

-

?

S-adenosyl-L-methionine + histamine

S-adenosyl-L-homocysteine + Ntau-methylhistamine

Mus musculus

-

-

441556

-

441556

?

S-adenosyl-L-methionine + histamine

S-adenosyl-L-homocysteine + Ntau-methylhistamine

Mus musculus

-

-

441564

-

-

?

S-adenosyl-L-methionine + histamine

S-adenosyl-L-homocysteine + Ntau-methylhistamine

Oryctolagus cuniculus

-

-

441556

-

441556

?

S-adenosyl-L-methionine + histamine

S-adenosyl-L-homocysteine + Ntau-methylhistamine

Rattus norvegicus

-

-

441556

-

441556

?

S-adenosyl-L-methionine + histamine

S-adenosyl-L-homocysteine + Ntau-methylhistamine

Rattus norvegicus

-

-

441560, 441561, 441562, 441566, 441568, 441572, 441574, 441575

-

-

?

S-adenosyl-L-methionine + histamine

S-adenosyl-L-homocysteine + Ntau-methylhistamine

Sus scrofa

-

-

441558, 441569, 661881

-

-

?

S-adenosyl-L-methionine + histamine

S-adenosyl-L-homocysteine + Ntau-methylhistamine

Sus scrofa

-

highly specific for histamine

441557

-

441557

?

S-adenosyl-L-methionine + histamine

S-adenosyl-L-homocysteine + Ntau-methylhistamine

Sus scrofa

-

given a negative correlation between diamine oxidase and HMT activities, the fraction of catabolized histamine decreases with increasing HMT activity

677114

-

-

?

additional information

?

-

Cavia porcellus

-

major pathway of histamine metabolism in mammals

441556

-

-

?

additional information

?

-

Felis catus

-

major pathway of histamine metabolism in mammals

441556

-

-

?

additional information

?

-

Homo sapiens

-

possible role in modulation of histamine mediated reactions in skin

441559

-

-

?

additional information

?

-

Homo sapiens

-

major enzyme for histamine inactivation in mammalian tissues

441578

-

-

?

additional information

?

-

Mus musculus

-

major pathway of histamine metabolism in mammals

441556

-

-

?

additional information

?

-

Oryctolagus cuniculus

-

major pathway of histamine metabolism in mammals

441556

-

-

?

additional information

?

-

Rattus norvegicus

-

major enzyme for histamine inactivation in mammalian tissues

441560

-

-

?

additional information

?

-

Rattus norvegicus

-

major pathway of histamine metabolism in mammals

441556

-

-

?