2.1.1.8: histamine N-methyltransferase
This is an abbreviated version!
For detailed information about histamine N-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.8
-
2.1.1.8
-
diamine
-
histaminergic
-
metoprine
-
thr105ile
-
l-histidine
-
radioenzymatic
-
thioperamide
-
tele-methylhistamine
-
aminoguanidine
-
histamine-induced
-
amodiaquine
-
s-adenosyl-l-homocysteine
-
3hhistamine
-
histamine-related
-
histamine-degrading
-
n-myristoyltransferase
-
pentagastrin
-
gene-dose
-
mepyramine
-
pyrilamine
-
phenylethanolamine
-
r-alpha-methylhistamine
-
histaminase
-
medicine
-
dimaprit
-
degradation
-
analysis
- 2.1.1.8
-
diamine
-
histaminergic
- metoprine
-
thr105ile
- l-histidine
-
radioenzymatic
- thioperamide
-
tele-methylhistamine
- aminoguanidine
-
histamine-induced
- amodiaquine
- s-adenosyl-l-homocysteine
-
3hhistamine
-
histamine-related
-
histamine-degrading
- n-myristoyltransferase
- pentagastrin
-
gene-dose
-
mepyramine
-
pyrilamine
- phenylethanolamine
-
r-alpha-methylhistamine
- histaminase
- medicine
- dimaprit
- degradation
- analysis
Reaction
Synonyms
histamine 1-methyltransferase, histamine methyltransferase, histamine N-methyltransferase, histamine-methylating enzyme, histamine-N-methyltransferase, HMT, HNMT, imidazole methyltransferase, imidazole N-methyltransferase, imidazolemethyltransferase, methyltransferase, histamine, Ntau-methyltransferase, S-adenosylmethionine-histamine N-methyltransferase
ECTree
2.1.1.8 histamine N-methyltransferaseAdvanced search results
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Reference on EC 2.1.1.8 - histamine N-methyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Brown, D.D.; Tomchick, R.; Axelrod, J.
The distribution and properties of a histamine-methylating enzyme
J. Biol. Chem.
234
2948-2950
1959
Cavia porcellus, Oryctolagus cuniculus, Felis catus, Mus musculus, Rattus norvegicus
Axelrod, J.
Histamine N-methyltransferase (pig liver)
Methods Enzymol.
17
766-769
1971
Cavia porcellus, Sus scrofa
-
Barth, H.; Lorenz, W.; Niemeyer, I.
Inhibition and activation of histamine methyltransferase by methylated histamines
Hoppe-Seyler's Z. Physiol. Chem.
354
1021-1026
1973
Sus scrofa
Francis, D.M.; Thompson, M.F.; Greaves, M.W.
The kinetic properties and reaction mechanism of histamine methyltransferase from human skin
Biochem. J.
187
819-828
1980
Homo sapiens
Bowsher, R.R.; Verburg, K.M.; Henry, D.P.
Rat histamine N-methyltransferase. Quantification, tissue distribution, purification, and immunologic properties
J. Biol. Chem.
258
12215-12220
1983
Rattus norvegicus
Harvima, R.J.; Kajander, E.O.; Harvima, I.T.; Fraki, J.E.
Purification and partial characterization of rat kidney histamine-N-methyltransferase
Biochim. Biophys. Acta
841
42-49
1985
Rattus norvegicus
Fukuda, H.; Yamatodani, A.; Imamura, I.; Maeyama, K.; Watanabe, T.; Wada, H.
High-performance liquid chromatographic determination of histamine N-methyltransferase activity
J. Chromatogr.
567
459-464
1991
Rattus norvegicus
Nishibori, M.; Oishi, R.; Itoh, Y.; Saeki, K.
Purification and partial characterization of histamine N-methyltransferase from bovine brain
Neurochem. Int.
19
135-141
1991
Bos taurus
-
Scott, M.C.; Guerciolini, R.; Szumlanski, C.; Weinshilboum, R.M.
Mouse kidney histamine N-methyltransferase: assay conditions, biochemical properties and strain variation
Agents Actions
32
194-202
1991
Homo sapiens, Mus musculus
Crooks, P.A.; Hassan, S.F.; Benghiat, E.; Hemrick-Luecke, S.K.; Fuller, R.W.
5'-Thioadenosine derivatives as potent and selective inhibitors of histamine N-methyltransferase
Drug Metabol. Drug Interact.
7
111-141
1989
Cavia porcellus
Rhim, H.; Choi, M.U.
Purification and general characterization of rat brain histamine N-methyltransferase
Hanguk Saenghwahakhoe Chi
22
455-461
1989
Rattus norvegicus
-
Gitomer, W.L.; Tipton, K.F.
Purification and kinetic properties of ox brain histamine N-methyltransferase
Biochem. J.
233
669-676
1986
Bos taurus
Fuhr, N.; Kownatzki, E.
Inhibition of rat kidney histamine-N-methyltransferase by biogenic amines
Pharmacology
32
114-120
1986
Rattus norvegicus
Barth, H.; Schunack, W.; Crombach, M.; Lorenz, W.
Gastric histamine methyltransferase: different methylation rates for enantiomers of side-chain methylated histamine analogues using a highly purified enzyme preparation
Agents Actions
14
346-350
1984
Sus scrofa
Matuszewska, B.; Borchardt, R.T.
Guinea pig brain histamine N-methyltransferase: purification and partial characterization
J. Neurochem.
41
113-118
1983
Cavia porcellus
Dent, C.; Nilam, F.; Smith, I.R.
Sidechain-modified histamine analogues as substrates for histamine N-methyltransferase
Biochem. Pharmacol.
31
2297-2300
1982
Cavia porcellus
Beaven, M.A.; Roderick, N.B.
Impromidine, a potent inhibitor of histamine methyltransferase (HMT) and diamine oxidase (DAO)
Biochem. Pharmacol.
29
2897-2900
1980
Rattus norvegicus
Thithapandha, A.; Cohn, V.H.
Brain histamine N-methyltransferase purification, mechanism of action, and inhibition by drugs
Biochem. Pharmacol.
27
263-271
1978
Cavia porcellus
Matuszewska, B.; Borchardt, R.T.
Rat kidney histamine N-methyltransferase: purification and partial characterization
Prep. Biochem.
15
145-157
1985
Rattus norvegicus
Borchardt, R.T.; Matuszewska, B.
S-adenosylmethionine dependent transmethylation of histamine: Purification and partial characterization of guinea pig brain and rat kidney histamine N-methyltransferase
Adv. Biosci.
51
163-172
1985
Cavia porcellus, Rattus norvegicus
-
Horton, J.R.; Sawada, K.; Nishibori, M.; Zhang, X.; Cheng, X.
Two polymorphic forms of human histamine methyltransferase. Structural, thermal, and kinetic comparisons
Structure
9
837-849
2001
Homo sapiens (P50135), Homo sapiens
Takemura, M.; Imamura, I.; Mizuguchi, H.; Fukui, H.; Yamatodani, A.
Tissue distribution of histamine N-methyltransferase-like immunoreactivity in rodents
Life Sci.
54
1059-1071
1994
Cavia porcellus, Mus musculus, Rattus norvegicus
Yamauchi, K.; Sekizawa, K.; Suzuki, H.; Nakazawa, H.; Ohkawara, Y.; Katayose, D.; Ohtsu, H.; Tamura, G.; Shibahara, S.; et al.
Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway
Am. J. Physiol.
267
L342-L349
1994
Homo sapiens
Tahara, A.; Nishibori, M.; Ohtsuka, A.; Sawada, K.; Sakiyama, J.; Saeki, K.
Immunohistochemical localization of histamine N-methyltransferase in guinea pig tissues
J. Histochem. Cytochem.
48
943-954
2000
Cavia porcellus
Preuss, C.V.; Wood, T.C.; Szumlanski, C.L.; Raftogianis, R.B.; Otterness, D.M.; Girard, B.; Scott, M.C.; Weinshilboum, R.M.
Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity
Mol. Pharmacol.
53
708-717
1998
Homo sapiens
Donatelli, P.; Marchi, G.; Giuliani, L.; Gustafsson, L.L.; Pacifici, G.M.
Stereoselective inhibition by chloroquine of histamine N-methyltransferase in the human liver and brain
Eur. J. Clin. Pharmacol.
47
345-349
1994
Homo sapiens
Pang, Y.P.; Zheng, X.E.; Weinshilboum, R.M.
Theoretical 3D model of histamine N-methyltransferase: Insights into the effects of a genetic polymorphism on enzymatic activity and thermal stability
Biochem. Biophys. Res. Commun.
287
204-208
2001
Homo sapiens (P50135), Homo sapiens
Schwelberger, H.G.; Drasche, A.
Structure and expression of porcine histamine N-methyltransferase
Inflamm. Res.
51
S85-S86
2002
Sus scrofa
-
Oroszi, G.; Enoch, M.A.; Chun, J.; Virkkunen, M.; Goldman, D.
Thr105Ile, a functional polymorphism of histamine N-methyltransferase, is associated with alcoholism in two independent populations
Alcohol. Clin. Exp. Res.
29
303-309
2005
Homo sapiens
Grassmann, S.; Apelt, J.; Sippl, W.; Ligneau, X.; Pertz, H.H.; Zhao, Y.H.; Arrang, J.M.; Ganellin, C.R.; Schwartz, J.C.; Schunack, W.; Stark, H.
Imidazole derivatives as a novel class of hybrid compounds with inhibitory histamine N-methyltransferase potencies and histamine hH3 receptor affinities
Bioorg. Med. Chem.
11
2163-2174
2003
Rattus norvegicus
Huetz, G.N.; Schwelberger, H.G.
Simultaneous purification of the histamine degrading enzymes diamine oxidase and histamine N-methyltransferase from the same tissue
Inflamm. Res.
52
S65-S66
2003
Sus scrofa
-
Kuefner, M.A.; Schwelberger, H.G.; Weidenhiller, M.; Hahn, E.G.; Raithel, M.
Both catabolic pathways of histamine via histamine-N-methyl-transferase and diamine oxidase are diminished in the colonic mucosa of patients with food allergy
Inflamm. Res.
53
S31-S32
2004
Homo sapiens
-
Taraschenko, O.D.; Barnes, W.G.; Herrick-Davis, K.; Yokoyama, Y.; Boyd, D.L.; Hough, L.B.
Actions of tacrine and galanthamine on histamine-N-methyltransferase
Methods Find. Exp. Clin. Pharmacol.
27
161-165
2005
Homo sapiens, Rattus norvegicus
Apelt, J.; Grassmann, S.; Ligneau, X.; Pertz, H.H.; Ganellin, C.R.; Arrang, J.M.; Schwartz, J.C.; Schunack, W.; Stark, H.
Search for histamine H3 receptor antagonists with combined inhibitory potency at Ntau-methyltransferase: ether derivatives
Pharmazie
60
97-106
2005
Rattus norvegicus
Feurle, J.; Rajtar, S.; Irman-Florjanc, T.; Schwelberger, H.G.
Molecular cloning of guinea-pig diamine oxidase and histamine N-methyltransferase
Inflamm. Res.
55
S59-S60
2006
Cavia porcellus
-
Horton, J.R.; Sawada, K.; Nishibori, M.; Cheng, X.
Structural basis for inhibition of histamine N-methyltransferase by diverse drugs
J. Mol. Biol.
353
334-344
2005
Homo sapiens (P50135)
Aschenbach, J.R.; Schwelberger, H.G.; Ahrens, F.; Fuerll, B.; Gaebel, G.
Histamine inactivation in the colon of pigs in relationship to abundance of catabolic enzymes
Scand. J. Gastroenterol.
41
712-719
2006
Sus scrofa
Rutherford, K.; Parson, W.W.; Daggett, V.
The histamine N-methyltransferase T105I polymorphism affects active site structure and dynamics
Biochemistry
47
893-901
2008
Homo sapiens (P50135), Homo sapiens
Cao, H.; Mei, Q.; Zhang, L.; Xu, J.
C314T polymorphism in histamine N-methyltransferase gene and susceptibility to duodenal ulcer in Chinese population.
Clin. Chim. Acta
391
130
2008
Homo sapiens
-
Reuter, M.; Jeste, N.; Klein, T.; Hennig, J.; Goldman, D.; Enoch, M.; Oroszi, G.
Association of THR105Ile, a functional polymorphism of histamine N-methyltransferase (HNMT), with alcoholism in German Caucasians
Drug Alcohol Depend.
87
69-75
2007
Homo sapiens
Yokoyama, A.; Mori, S.; Takahashi, H.K.; Kanke, T.; Wake, H.; Nishibori, M.
Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice
Eur. J. Pharmacol.
558
179-184
2007
Mus musculus
Rajtar, S.; Irman-Florjanc, T.
Amitriptyline affects histamine-N-methyltransferase and diamine oxidase activity in rats and guinea pigs
Eur. J. Pharmacol.
574
201-208
2007
Cavia porcellus, Rattus norvegicus
Ledesma, M.C.; Garcia-Martin, E.; Alonso-Navarro, H.; Martinez, C.; Jimenez-Jimenez, F.J.; Benito-Leon, J.; Puertas, I.; Rubio, L.; Lopez-Alburquerque, T.; Agundez, J.A.
The Nonsynonymous Thr105Ile Polymorphism of the Histamine N-Methyltransferase is Associated to the Risk of Developing Essential Tremor
Neuromolecular Med.
10
356-361
2008
Homo sapiens
Huang, C.C.; Huang, C.W.; Cheng, Y.S.; Yu, J.
Histamine metabolism influences blood vessel branching in zebrafish reg6 mutants
BMC Dev. Biol.
8
31
2008
Danio rerio
Kim, S.H.; Kang, Y.M.; Kim, S.H.; Cho, B.Y.; Ye, Y.M.; Hur, G.Y.; Park, H.S.
Histamine N-methyltransferase 939A>G polymorphism affects mRNA stability in patients with acetylsalicylic acid-intolerant chronic urticaria
Allergy
64
213-221
2009
Homo sapiens
Dave, S.; Rahatgaonkar, A.
Computational evaluation of 2-phenyl-4H-chromen-4-one analogues as antihistamines: Potential histamine N-methyltransferase (HMT) inhibitors
E-J. Chem.
6
1009-1016
2009
Homo sapiens
-
von Mach-Szczypi?ski, J.; Stanosz, S.; Sieja, K.; Stanosz, M.
Histamine and its metabolizing enzymes in tissues of primary ductal breast cancer
Eur. J. Gynaecol. Oncol.
30
509-511
2009
Homo sapiens
Osredkar, D.; Burnik-Papler, T.; Pecavar, B.; Kralj-Iglic, V.; Krzan, M.
Kinetic and pharmacological properties of [(3)H]-histamine transport into cultured type 1 astrocytes from neonatal rats
Inflamm. Res.
58
94-102
2009
Rattus norvegicus
Agundez, J.; Luengo, A.; Herraez, O.; Martinez, C.; Alonso-Navarro, H.; Jimenez-Jimenez, F.; Garcia-Martin, E.
Nonsynonymous polymorphisms of histamine-metabolising enzymes in patients with Parkinsons disease
Neuromolecular Med.
10
10-16
2008
Homo sapiens (P50135), Homo sapiens
Palada, V.; Terzi?, J.; Mazzulli, J.; Bwala, G.; Hagenah, J.; Peterlin, B.; Hung, A.Y.; Klein, C.; Krainc, D.
Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinsons disease
Neurobiol. Aging
33
836.e1-3
2012
Homo sapiens
Kuefner, M.A.; Feurle, J.; Petersen, J.; Uder, M.; Schwelberger, H.G.
Influence of iodinated contrast media on the activities of histamine inactivating enzymes diamine oxidase and histamine N-methyltransferase in vitro
Allergol. Immunopathol. (Madr.)
42
324-328
2014
Homo sapiens (P50135), Homo sapiens
Tongsook, C.; Niederhauser, J.; Kronegger, E.; Straganz, G.; Macheroux, P.
Leucine 208 in human histamine N-methyltransferase emerges as a hotspot for protein stability rationalizing the role of the L208P variant in intellectual disability
Biochim. Biophys. Acta
1863
188-199
2017
Homo sapiens (P50135), Homo sapiens
Jia, H.Z.; Liu, S.L.; Zou, Y.F.; Chen, X.F.; Yu, L.; Wan, J.; Zhang, H.Y.; Chen, Q.; Xiong, Y.; Yu, B.; Zhang, W.
MicroRNA-223 is involved in the pathogenesis of atopic dermatitis by affecting histamine-N-methyltransferase
Cell. Mol. Biol. (Noisy-le-grand)
64
103-107
2018
Homo sapiens (P50135), Homo sapiens
Maw, H.H.; Zeng, X.; Campbell, S.; Taub, M.E.; Teitelbaum, A.M.
N-Methylation of BI 187004 by thiol S-methyltransferase
Drug Metab. Dispos.
46
770-778
2018
Homo sapiens (P50135), Homo sapiens
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