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2.1.1.74: methylenetetrahydrofolate-tRNA-(uracil54-C5)-methyltransferase [NAD(P)H-oxidizing]

This is an abbreviated version!
For detailed information about methylenetetrahydrofolate-tRNA-(uracil54-C5)-methyltransferase [NAD(P)H-oxidizing], go to the full flat file.

Word Map on EC 2.1.1.74

Reaction

5,10-methylenetetrahydrofolate
+
uracil54 in tRNA
 +
NAD(P)H
 +
H+
=
tetrahydrofolate
 +
5-methyluracil54 in tRNA
 +
NAD(P)+

Synonyms

EC 2.1.2.12, FDRTS, folate-dependent ribothymidyl synthase, folate-dependent tRNA methyltransferase, folate/FAD-dependent tRNA T54 methyltransferase, methylenetetrahydrofolate-transfer ribonucleate uracil 5-methyltransferase,, TRMFO, tRNA (m5U54)-methyltransferase, tRNA:m5U-54 MTase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.74 methylenetetrahydrofolate-tRNA-(uracil54-C5)-methyltransferase [NAD(P)H-oxidizing]

Substrates Products

Substrates Products on EC 2.1.1.74 - methylenetetrahydrofolate-tRNA-(uracil54-C5)-methyltransferase [NAD(P)H-oxidizing]

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
5,10-methylenetetrahydrofolate + tRNA containing uridine at position 54 + FADH2
tetrahydrofolate + tRNA containing ribothymidine at position 54 + FAD
show the reaction diagram
5,10-methylenetetrahydrofolate + tRNA UpsiC + FADH2
tetrahydrofolate + tRNA TpsiC + FAD
show the reaction diagram
5,10-methylenetetrahydrofolate + tRNA UpsiC + NADH
tetrahydrofolate + tRNA TpsiC + NAD+
show the reaction diagram
-
-
-
-
?
5,10-methylenetetrahydrofolate + uracil54 in tRNA + FADH2
tetrahydrofolate + 5-methyluracil54 in tRNA + FAD
show the reaction diagram
-
-
-
?
N5,N10-methylenetetrahydrofolate + tRNA containing uridine at position 54 + FADH2
tetrahydrofolate + tRNA containing ribothymidine at position 54 + FAD
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + tRNAPhe containing uridine at position 54
S-adenosyl-L-homocysteine + tRNAPhe containing ribothymidine at position 54
show the reaction diagram
S-adenosyl-L-methionine + tRNAPhe mutant A58G containing uridine at position 54
S-adenosyl-L-homocysteine + tRNAPhe mutant A58G containing ribothymidine at position 54
show the reaction diagram
S-adenosyl-L-methionine + tRNAPhe mutant A58U containing uridine at position 54
S-adenosyl-L-homocysteine + tRNAPhe mutant A58U containing ribothymidine at position 54
show the reaction diagram
S-adenosyl-L-methionine + tRNAPhe mutant G57A containing uridine at position 54
S-adenosyl-L-homocysteine + tRNAPhe mutant G57A containing ribothymidine at position 54
show the reaction diagram
S-adenosyl-L-methionine + tRNAPhe nucleotides 18-76 containing uridine at position 54
S-adenosyl-L-homocysteine + tRNAPhe nucleotides 18-76 containing ribothymidine at position 54
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + tRNAPhe nucleotides 44-76 containing uridine at position 54
S-adenosyl-L-homocysteine + tRNAPhe nucleotides 44-76 containing ribothymidine at position 54
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + tRNAPhe with deletions of aminoacyl stem and D-arm containing uridine at position 54
S-adenosyl-L-homocysteine + tRNAPhe with deletions of aminoacyl stem and D-arm containing ribothymidine at position 54
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + tRNAPhe with deletions of aminoacyl stem containing uridine at position 54
S-adenosyl-L-homocysteine + tRNAPhe with deletions of aminoacyl stem containing ribothymidine at position 54
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + tRNAPhe with deletions of anticodon arm containing uridine at position 54
S-adenosyl-L-homocysteine + tRNAPhe with deletions of anticodon armand D-arm containing ribothymidine at position 54
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + tRNAPhe with deletions of D-arm containing uridine at position 54
S-adenosyl-L-homocysteine + tRNAPhe with deletions of D-arm containing ribothymidine at position 54
show the reaction diagram
-
-
-
?
additional information
?
-