2.1.1.69: 5-hydroxyfuranocoumarin 5-O-methyltransferase

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For detailed information about 5-hydroxyfuranocoumarin 5-O-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.69

2.1.1.69

ammonia-lyase

phenylpropanoid

parsley

bergapten

peucedanum

petroselinum

crispum

praeruptorum

4-coumarate:coa

psoralens

megasperma

jasmonate

methoxylated

coumarins

seedlings

phytophthora

glycinea

pathogenesis-related

elicitor

majus

wounding

chalcone

Reaction

Synonyms

bergaptol O-methyltransferase, bergaptol-5-O-methyltransferase, BMT, EC 2.1.1.92, furanocoumarin 5-methyltransferase, furanocoumarin 5-O-methyltransferase, methyltransferase, bergaptol

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.69 5-hydroxyfuranocoumarin 5-O-methyltransferase

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Results	in table
5	AA Sequence
2	CAS Registry Number
4	Cloned(Commentary)
1	Cofactor
1	Crystallization (Commentary)
1	Expression
1	General Stability
15	Inhibitors
7	KM Value [mM]
2	Localization
1	Metals/Ions
5	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
15	Organism
1	Pathway
1	PDB ID
5	pH Optimum
3	pH Range
1	pH Stability
2	pI Value
31	Protein Variants
5	Purification (Commentary)
2	Reaction
1	Reaction Type
15	Reference
21	Source Tissue
4	Specific Activity [micromol/min/mg]
3	Storage Stability
35	Substrates and Products (Substrate)
5	Subunits
11	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Temperature Range [°C]

Systematic Name

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Systematic Name on EC 2.1.1.69 - 5-hydroxyfuranocoumarin 5-O-methyltransferase

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S-adenosyl-L-methionine:5-hydroxyfurocoumarin 5-O-methyltransferase

Converts bergaptol into bergapten, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities [4]. The enzyme methylates the 5-hydroxy group of some hydroxy- and methylcoumarins, such as 5-hydroxyxanthotoxin [3], but has little activity on non-coumarin phenols [1]. Caffeate, 5-hydroxyferulate and daphnetin are not substrates [4]. Cu2+, Zn2+ and Co2+ cause enzyme inhibition [4]. (see also EC 2.1.1.70, 8-hydroxyfuranocoumarin 8-O-methyltransferase)