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2.1.1.67: thiopurine S-methyltransferase

This is an abbreviated version!
For detailed information about thiopurine S-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.67

Reaction

S-adenosyl-L-methionine
+
a thiopurine
=
S-adenosyl-L-homocysteine
 +
a thiopurine S-methylether

Synonyms

6-thiopurine S-methyltransferase, 6-thiopurine transmethylase, mercaptopurine methyltransferase, thiopurine methyl transferase, thiopurine methyltransferase, thiopurine S-methyltransferase, thiopurine-S-methyl-transferase, TMPT, TPMT

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.67 thiopurine S-methyltransferase

Expression

Expression on EC 2.1.1.67 - thiopurine S-methyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
azathioprine therapy can raise TPMT activity
-
decreased activity of TPMT is associated with hematopoietic toxicity after administration of standard doses of 6- mercaptopurine or azathioprine
-
longitudinal induction of thiopurine methyltransferase activity is observed during 6-thioguanine treatment
-
S-adenosyl-L-methionine has no effect on TPMT mRNA expression
-
smokers have significantly higher TPMT activity than nonsmokers
-
the restriction of L-methionine in cell growth media reversibly decreases enzyme activity and protein levels
-
TPMT activity is significantly higher in wild type children than in wild type adults (18-68 years), wild type infants from 0.08-5 years has a 9% higher average TPMT activity than the other wild type groups, only in children from 0.08-2 years is the TPMT activity higher in males than in females
-