2.1.1.67: thiopurine S-methyltransferase
This is an abbreviated version!
For detailed information about thiopurine S-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.67
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2.1.1.67
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azathioprine
-
6-mercaptopurine
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bowel
-
pharmacogenetics
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children
-
lymphoblastic
-
leukemia
-
myelosuppression
-
erythrocyte
-
tpmt*2
-
crohn
-
thioguanine
-
dosing
-
s-methylation
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autoimmune
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marrow
-
remission
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caucasian
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leukopenia
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myelotoxicity
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ulcerative
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6-methylmercaptopurine
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methotrexate
-
ethnic
-
inosine
-
colitis
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azathioprine-induced
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medicine
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allele-specific
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interindividual
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nudt15
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5-aminosalicylic
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thiopurine-induced
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allopurinol
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pancytopenia
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neutropenia
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dihydropyrimidine
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infliximab
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drug-metabolizing
-
pyrophosphohydrolase
-
trimodal
-
hematotoxicity
-
analysis
-
nudix
-
pemphigus
-
diagnostics
-
mofetil
- 2.1.1.67
- azathioprine
- 6-mercaptopurine
- bowel
-
pharmacogenetics
- children
- lymphoblastic
- leukemia
-
myelosuppression
- erythrocyte
-
tpmt*2
- crohn
- thioguanine
-
dosing
-
s-methylation
- autoimmune
- marrow
-
remission
-
caucasian
- leukopenia
-
myelotoxicity
-
ulcerative
- 6-methylmercaptopurine
- methotrexate
-
ethnic
- inosine
- colitis
-
azathioprine-induced
- medicine
-
allele-specific
-
interindividual
-
nudt15
-
5-aminosalicylic
-
thiopurine-induced
- allopurinol
- pancytopenia
- neutropenia
- dihydropyrimidine
-
infliximab
-
drug-metabolizing
-
pyrophosphohydrolase
-
trimodal
-
hematotoxicity
- analysis
-
nudix
- pemphigus
- diagnostics
- mofetil
Reaction
Synonyms
6-thiopurine S-methyltransferase, 6-thiopurine transmethylase, mercaptopurine methyltransferase, thiopurine methyl transferase, thiopurine methyltransferase, thiopurine S-methyltransferase, thiopurine-S-methyl-transferase, TMPT, TPMT
ECTree
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Crystallization
Crystallization on EC 2.1.1.67 - thiopurine S-methyltransferase
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two crystal structures of murine TPMT are determined, as a binary complex with the product S-adenosyl-L-homocysteine and as a ternary complex with S-adenosyl-L-homocysteine and the substrate 6-mercaptopurine, to 1.8 and 2.0 A resolution, respectively