2.1.1.64: 3-demethylubiquinol 3-O-methyltransferase
This is an abbreviated version!
For detailed information about 3-demethylubiquinol 3-O-methyltransferase, go to the full flat file.
Reaction
Synonyms
2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase, 5-demethylubiquinone-9 methyltransferase, 5-demethylubiquinone-9-methyltransferase, AtCOQ3, COQ3, Coq3 O-methyltransferase, O-methyltransferase, OMHMB methyltransferase, OMHMB-methyltransferase, S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase, UbiG, UbiG methyltransferase, ubiquinone biosynthesis O-methyltransferase
ECTree
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Substrates Products
Substrates Products on EC 2.1.1.64 - 3-demethylubiquinol 3-O-methyltransferase
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REACTION DIAGRAM
S-adenosyl-L-methionine + 3-demethylubiquinol-10
S-adenosyl-L-homocysteine + ubiquinol-10 + H+
the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-10, 1. the methylation of 3,4-dihydroxy-5-all-trans-decaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-10
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S-adenosyl-L-methionine + 3-demethylubiquinol-n
S-adenosyl-L-homocysteine + ubiquinol-n
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additional information
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wide substrate specificity. The enzyme methylates both eukaryotic substrates 3,4-dihydroxy-5-farnesylbenzoic acid (this activity is classified as EC 2.1.1.114) and demethylubiquinol-3 and the distinct prokaryotic substrate 3-((2E,6E)-farnesyl)benzene-1,2-diol
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S-adenosyl-L-homocysteine + ubiquinol-3
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i.e. 5-((2E,6E)-farnesyl)-2-hydroxy-3-methoxy-6-methyl-1,4-benzoquinone
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S-adenosyl-L-methionine + 3-demethylubiquinol-3
S-adenosyl-L-homocysteine + ubiquinol-3
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i.e. 5-(2E,6E)-farnesyl-2-hydroxy-3-methoxy-6-methyl-1,4-benzoquinone
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S-adenosyl-L-methionine + 3-demethylubiquinol-3
S-adenosyl-L-homocysteine + ubiquinol-3
i.e. 5-(2E,6E)-farnesyl-2-hydroxy-3-methoxy-6-methyl-1,4-benzoquinone, in vitro assay
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S-adenosyl-L-methionine + 3-demethylubiquinol-3
S-adenosyl-L-homocysteine + ubiquinol-3
i.e. 5-(2E,6E)-farnesyl-2-hydroxy-3-methoxy-6-methyl-1,4-benzoquinone, in vitro assay
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S-adenosyl-L-methionine + 3-demethylubiquinol-3
S-adenosyl-L-homocysteine + ubiquinol-3
i.e. 5-(2E,6E)-farnesyl-2-hydroxy-3-methoxy-6-methyl-1,4-benzoquinone
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S-adenosyl-L-homocysteine + ubiquinol-6
3-demethylubiquinol-6 is an intermediate in biosynthesis of ubiquinone-6 in Saccharomyces cerevisiae (methylated by the yeast enzyme COQ3 to ubiquinol-6). The human construct rescues the growth of a yeast coq3 null mutant on a nonfermentable carbon source and restores coenzyme Q biosynthesis, although at lower levels than that of wild type yeast
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S-adenosyl-L-methionine + 3-demethylubiquinol-6
S-adenosyl-L-homocysteine + ubiquinol-6
the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-6 in Saccharomyces cerevisiae, 1. the methylation of 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-6
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S-adenosyl-L-homocysteine + ubiquinol-8
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involved in biosynthesis of ubiquinone-8
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S-adenosyl-L-methionine + 3-demethylubiquinol-8
S-adenosyl-L-homocysteine + ubiquinol-8
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the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-8 in Escherichia coli, 1. the methylation of 3,4-dihydroxy-5-all-trans-octaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-8
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S-adenosyl-L-methionine + 3-demethylubiquinol-8
S-adenosyl-L-homocysteine + ubiquinol-8
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the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-8 in Escherichia coli, 1. the methylation of 3,4-dihydroxy-5-octaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-8
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S-adenosyl-L-methionine + 3-demethylubiquinol-8
S-adenosyl-L-homocysteine + ubiquinol-8
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i.e. 2-all-trans-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol
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S-adenosyl-L-homocysteine + ubiquinol-9
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S-adenosyl-L-methionine + 3-demethylubiquinol-9
S-adenosyl-L-homocysteine + ubiquinol-9
involved in biosynthesis of ubiquinone-9
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S-adenosyl-L-methionine + 3-demethylubiquinol-9
S-adenosyl-L-homocysteine + ubiquinol-9
the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-9 in Rattus norvegicus, 1. the methylation of 3,4-dihydroxy-5-all-trans-octaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-9
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