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2.1.1.63: methylated-DNA-[protein]-cysteine S-methyltransferase

This is an abbreviated version!
For detailed information about methylated-DNA-[protein]-cysteine S-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.63

Reaction

DNA (containing 4-O-methylthymine)
+
protein L-cysteine
=
DNA (without 4-O-methylthymine)
 +
protein S-methyl-L-cysteine

Synonyms

Ada protein, Ada-C, AGAT, AGT, AGTendoV, alkylated DNA-protein alkyltransferase, alkylguanine transferase, ATASE, C-hAGT, carboxyl terminal domain of the inducible Escherichia coli ada alkyltransferase, hAGT, methylated-DNA-[protein]-cysteine S-methyltransferase, methylguanine DNA methyltransferase, MGMT, Mgt1, MJ1529, N-hAGT, O6-alkylguanine DNA alkyltransferase, O6-alkylguanine DNA-alkyltransferase, O6-alkylguanine-DNA alkyl-transferase, O6-alkylguanine-DNA alkyltransferase, O6-methylguanine DNA methyltransferase, O6-methylguanine methyltransferase, O6-methylguanine-DNA methyltransferase, O6-methylguanine-DNA-methyltransferase, O6-MGMT, O6meG-DNA alkyltransferase, OGT, Pk-MGMT, SSO2487, Tk-MGMT, TTHA1564

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.63 methylated-DNA-[protein]-cysteine S-methyltransferase

Organic Solvent Stability

Organic Solvent Stability on EC 2.1.1.63 - methylated-DNA-[protein]-cysteine S-methyltransferase

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ORGANIC SOLVENT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2,2,2-trifluoroethanol
-
enzyme retains its native structure at high concentrations
2-propanol
-
enzyme retains its native structure at high concentrations
Ethanol
-
enzyme retains its native structure at high concentrations
Methanol
-
enzyme retains its native structure at high concentrations
SDS
-
enzyme retains its native structure at high concentrations
urea
-
5 mM, melting temperature of wild-type enzyme: 91.5 °C, melting temperature of mutant enzyme E83A: 89.2°C, melting temperature of mutant enzyme E93A: 85.5°C, melting temperature of mutant enzyme E158A: 90.6°C, melting temperature of mutant enzyme E159A: 91.7 °C