2.1.1.63: methylated-DNA-[protein]-cysteine S-methyltransferase

This is an abbreviated version!
For detailed information about methylated-DNA-[protein]-cysteine S-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.63

2.1.1.63

glioblastoma

temozolomide

glioma

o6-benzylguanine

adduct

resect

hypermethylation

methylation-specific

radiotherapy

unmethylated

mismatch

nitrosoureas

isocitrate

cpg

n-methyl-n'-nitro-n-nitrosoguanidine

multiforme

chloroethylnitrosoureas

progression-free

1,3-bis2-chloroethyl-1-nitrosourea

chloroethylating

n-methyl-n-nitrosourea

astrocytomas

carmustine

o6-meg

interstrand

glycosylase

dna-repair

anaplastic

karnofsky

dacarbazine

repair-deficient

tmz-induced

methylnitrosourea

phosphotriester

n-nitroso

myelosuppression

chemoradiotherapy

oligodendrogliomas

tmz-resistant

medicine

procarbazine

p14arf

drug development

diagnostics

lomustine

miscoding

idh-mutant

analysis

idh-wildtype

dna-alkylating

repair-proficient

neuro-oncology

premutagenic

codeletion

molecular biology

Reaction

Synonyms

Ada protein, Ada-C, AGAT, AGT, AGTendoV, alkylated DNA-protein alkyltransferase, alkylguanine transferase, ATASE, C-hAGT, carboxyl terminal domain of the inducible Escherichia coli ada alkyltransferase, hAGT, methylated-DNA-[protein]-cysteine S-methyltransferase, methylguanine DNA methyltransferase, MGMT, Mgt1, MJ1529, N-hAGT, O6-alkylguanine DNA alkyltransferase, O6-alkylguanine DNA-alkyltransferase, O6-alkylguanine-DNA alkyl-transferase, O6-alkylguanine-DNA alkyltransferase, O6-methylguanine DNA methyltransferase, O6-methylguanine methyltransferase, O6-methylguanine-DNA methyltransferase, O6-methylguanine-DNA-methyltransferase, O6-MGMT, O6meG-DNA alkyltransferase, OGT, Pk-MGMT, SSO2487, Tk-MGMT, TTHA1564

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.63 methylated-DNA-[protein]-cysteine S-methyltransferase

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
11	Activating Compound
37705	AA Sequence
36	Application
1	CAS Registry Number
31	Cloned(Commentary)
1	Cofactor
5	Crystallization (Commentary)
3061	Disease/ Diagnostics
11	Expression
16	General Information
4	General Stability
42	IC50 Value
106	Inhibitors
3	KM Value [mM]
8	Localization
3	Metals/Ions
22	Molecular Weight [Da]
58	Natural Substrates/ Products (Substrates)
6	Organic Solvent Stability
217	Organism
46	PDB ID
2	pH Optimum
2	pH Range
122	Protein Variants
25	Purification (Commentary)
2	Reaction
7	Reaction Type
124	Reference
1	Renatured (Commentary)
132	Source Tissue
4	Specific Activity [micromol/min/mg]
4	Storage Stability
141	Substrates and Products (Substrate)
19	Subunits
217	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]
7	Temperature Range [°C]
29	Temperature Stability [°C]
4	Turnover Number [1/s]

IC50 Value

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

IC50 Value on EC 2.1.1.63 - methylated-DNA-[protein]-cysteine S-methyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to IC50 Value Search

0.00033

2-([2-amino-6-[(4-bromothiophen-2-yl)methoxy]-9H-purin-9-yl]methoxy)ethanol

Homo sapiens

686337

0.000006

4-[(4-bromothiophen-2-yl)methoxy]-1H-pyrazolo[3,4-d]pyrimidin-6-amine

Homo sapiens

686337

0.00008

6-(1-benzofuran-2-ylmethoxy)-9H-purin-2-amine

Homo sapiens

686337

0.185

6-(4,5,6,7-tetrahydro-1-benzothiophen-2-ylmethoxy)-9H-purin-2-amine

Homo sapiens

686337

0.000022

6-(naphtho[1,2-b]thiophen-2-ylmethoxy)-9H-purin-2-amine

Homo sapiens

686337

0.00005

6-(naphtho[2,1-b]thiophen-2-ylmethoxy)-9H-purin-2-amine

Homo sapiens

686337

0.0011

6-(phenanthro[9,10-b]thiophen-2-ylmethoxy)-9H-purin-2-amine

Homo sapiens

686337

0.00055

6-[(1-methyl-4-nitro-1H-pyrrol-2-yl)methoxy]-9H-purin-2-amine

Homo sapiens

686337

0.000095

6-[(4-bromothiophen-2-yl)methoxy]-9-(2-deoxy-beta-D-erythro-pentofuranosyl)-9H-purin-2-amine

Homo sapiens

686337

0.000045

7-[(4-bromothiophen-2-yl)methoxy]-2,3-dihydro-1H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine

Homo sapiens

686337

0.000115

9-beta-D-arabinofuranosyl-6-[(4-bromothiophen-2-yl)methoxy]-9H-purin-2-amine

Homo sapiens

686337

0.0000018

DNA (containing 6-O-carboxymethylguanine)

Homo sapiens

in 50 mM Tris-HCl pH 8.3, at 37°C

734793

0.00000093

DNA (containing 6-O-methylguanine)

Homo sapiens

in 50 mM Tris-HCl pH 8.3, at 37°C

734793

0.0000014 - 0.000003

double-stranded oligonucleotides

Homo sapiens

6-O-methylguanine, 6-O-(4-fluorobenzyl)-guanine, 6-O-(3-fluorobenzyl)-guanine, 6-O-(2-fluorobenzyl)-guanine, 6-O-benzylguanine, 6-O-benzylhypoxanthine. IC50: 1.4-3.0 nM

485491

0.0005

N9-cyclopentyl-O6-(4-bromothenyl)guanine

Homo sapiens

P16455

673072

0.000025

O4-(4-bromothenylpterin)

Homo sapiens

686337

0.00007

O6-(1,2-thiazol-4-ylmethyl)guanine

Homo sapiens

686337

0.00035

O6-(1,3-oxazol-5-yl)guanine

Homo sapiens

686337

0.000033

O6-(1,3-thiazol-5-yl)guanine

Homo sapiens

686337

0.000035

O6-(1-benzofuran-2-ylmethyl)guanine

Homo sapiens

686337

0.00003

O6-(2-benzo[b]thienylmethyl)guanine

Homo sapiens

686337

0.00043

O6-(3-pyridyl)guanine

Homo sapiens

686337

0.00004

O6-(4-(2-chloropyridyl))guanine

Homo sapiens

686337

0.00024

O6-(4-bromothenyl)-8-oxaguanine

Homo sapiens

686337

0.0000028

O6-(4-bromothenyl)-8-thiaguanine

Homo sapiens

686337

0.0000001 - 0.0000034

O6-(4-bromothenyl)guanine

2 entries

0.00013

O6-(4-pyridyl)guanine

Homo sapiens

686337

0.00009 - 1.2

O6-benzylguanine

11 entries

0.0003

O6-furfurylguanine

Homo sapiens

686337

0.000018

O6-thenylguanine

Homo sapiens

686337

0.0085

O6-[(1-methyl-1H-imidazol-5-yl)methyl]guanine

Homo sapiens

686337