2.1.1.61: tRNA 5-(aminomethyl)-2-thiouridylate-methyltransferase

This is an abbreviated version!
For detailed information about tRNA 5-(aminomethyl)-2-thiouridylate-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.61

2.1.1.61

infantile

infant

homoplasmic

myopathy

leigh

l-cysteine

medicine

Reaction

5-aminomehtyl-2-thiouridine34 in tRNALys

5-methylaminomehtyl-2-thiouridine34 in tRNALys

Synonyms

5-methylaminomethyl-2-thiouridylate methyltransferase, 5-methylaminomethyl-2-thiouridylate-methyltransferase, methylaminomethyl-2-thiouridylate-methyltransferase, methyltransferase, transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-, MTO2, MTU1, S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase, transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase, TRMU, tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase, tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase, tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.61 tRNA 5-(aminomethyl)-2-thiouridylate-methyltransferase

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Results	in table
2	Activating Compound
8785	AA Sequence
2	Application
1	CAS Registry Number
3	Cloned(Commentary)
16	Disease/ Diagnostics
1	Expression
3	General Information
4	Inhibitors
8	Localization
1	Metals/Ions
3	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
185	Organism
1	Pathway
8	PDB ID
1	pH Optimum
1	pI Value
8	Protein Variants
3	Purification (Commentary)
2	Reaction
1	Reaction Type
10	Reference
20	Source Tissue
2	Specific Activity [micromol/min/mg]
10	Substrates and Products (Substrate)
3	Subunits
20	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Temperature Stability [°C]
1	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.1.1.61 - tRNA 5-(aminomethyl)-2-thiouridylate-methyltransferase

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S-adenosyl-L-methionine + 5-aminomethyl-2-thiouridine in tRNA

S-adenosyl-L-homocysteine + 5-methylaminomethyl-2-thiouridylate in tRNA

7 entries

S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine

S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate

Escherichia coli

441224

additional information

Escherichia coli

the enzyme exhibits two activities: enzyme from trmC1 mutant reacts with 5-carboxymethylaminomethyl-2-thiouridine to form 5-aminomethyl-2-thiouridine without S-adenosyl-L-methionine, enzyme from trmC2 mutant methylates 5-aminomethyl-2-thiouridine in the presence of S-adenosyl-L-methionine

441224