2.1.1.60: calmodulin-lysine N-methyltransferase

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For detailed information about calmodulin-lysine N-methyltransferase, go to the full flat file.

Reaction

Synonyms

calmodulin lysine methyl transferase, calmodulin lysine methyltransferase, calmodulin lysine N-methyltransferase, calmodulin methyltransferase, calmodulin N-methyltransferase, calmodulin-lysine N-methyltransferase, CaM KMT, CaM Lys methyltransferase, CaMKMT, methyltransferase, calmodulin (lysine), S-adenosylmethionine:calmodulin N-methyltransferase (lysine)

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.60 calmodulin-lysine N-methyltransferase

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Results	in table
11	Activating Compound
1465	AA Sequence
1	CAS Registry Number
5	Cloned(Commentary)
7	Disease/ Diagnostics
4	General Information
1	General Stability
12	Inhibitors
2	Ki Value [mM]
9	KM Value [mM]
9	Localization
10	Metals/Ions
8	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
18	Organism
2	Pathway
1	PDB ID
4	pH Optimum
6	Purification (Commentary)
2	Reaction
1	Reaction Type
18	Reference
19	Source Tissue
2	Specific Activity [micromol/min/mg]
2	Storage Stability
25	Substrates and Products (Substrate)
4	Subunits
19	Synonyms
1	Systematic Name

General Information

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General Information on EC 2.1.1.60 - calmodulin-lysine N-methyltransferase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

2 entries

metabolism

Homo sapiens

Q7Z624

the enzyme is the major methyltransferase of calmodulin in human cells and a Hsp90 client protein

735078

physiological function

Mus musculus

Q3U2J5

the enzyme is essential for normal body growth and somatosensory development, as well as for the proper functioning of the adult mouse brain

734999

malfunction

Mus musculus

Q3U2J5

enzyme-deficient mice have deficits in motor learning, complex coordination and learning of aversive stimuli

734999

malfunction

Homo sapiens

Q7Z624

the absence of enzyme causes accumulation of hypomethylated calmodulin in 2p21 deletion syndrome patients

735078