2.1.1.6: catechol O-methyltransferase

This is an abbreviated version!
For detailed information about catechol O-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.6

2.1.1.6

dopamine

val158met

catechols

parkinson

monoamine

dopaminergic

schizophrenia

prefrontal

levodopa

estrogen

val

o-methylation

psychiatric

norepinephrine

entacapone

l-dopa

tolcapone

serotonin

noradrenaline

dyskinesia

neurotransmitter

striatal

psycho

dopac

carbidopa

verbal

3,4-dihydroxyphenylacetic

extraneuronal

5-httlpr

low-activity

parkinsonian

homovanillic

normetanephrine

benserazide

antiparkinsonian

synthesis

endophenotype

dsm-iv

3h-noradrenaline

2-methoxyestradiol

analysis

tropolone

updrs

slc6a4

dihydroxyphenylacetic

amantadine

pargyline

oxidase-b

phenylethanolamine-n-methyltransferase

metanephrine

selegiline

medicine

antisocial

Reaction

Synonyms

catechol methyltransferase, catechol-O-methyl transferase, catechol-O-methyl transferase, membrane bound, catechol-O-methyl transferase, soluble, catechol-O-methyltransferase, catechol-O-transferase, catecholamine O-methyltransferase, COMT, COMT I, COMT II, COMT-mb, COMT-s, COMT1, COMT2, CTOMT1, L-COMT, MB-COMT, methyltransferase, catechol, S-COMT, SCOMT

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.6 catechol O-methyltransferase

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Results	in table
4	Activating Compound
1399	AA Sequence
30	Application
1	CAS Registry Number
22	Cloned(Commentary)
12	Crystallization (Commentary)
2407	Disease/ Diagnostics
6	Expression
10	General Information
2	General Stability
143	IC50 Value
304	Inhibitors
1	kcat/KM [mM/s]
53	Ki Value [mM]
145	KM Value [mM]
86	Localization
33	Metals/Ions
33	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
190	Organism
10	Pathway
184	PDB ID
17	pH Optimum
1	pH Range
3	Posttranslational Modification
28	Protein Variants
31	Purification (Commentary)
8	Reaction
2	Reaction Type
189	Reference
202	Source Tissue
17	Specific Activity [micromol/min/mg]
5	Storage Stability
294	Substrates and Products (Substrate)
16	Subunits
119	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
5	Temperature Stability [°C]
17	Turnover Number [1/s]

pH Optimum

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pH Optimum on EC 2.1.1.6 - catechol O-methyltransferase

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6.8 - 8.4

Homo sapiens

leads to maximal formation of 2-methoxyestradiol-17beta

441523

Rattus norvegicus

membrane-bound enzyme

7 - 8

7.1 - 7.4

7.3 - 8.2

7.4

membrane-bound activity

7.5

7.5 - 8.2

7.6 - 7.8

7.8

8 - 8.5

9.2

leads to maximal formation of 2- and 3-monomethyl ether

441523

additional information

Rattus norvegicus

P22734

wild-type is independent of pH

755786