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2.1.1.6: catechol O-methyltransferase

This is an abbreviated version!
For detailed information about catechol O-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.6

Reaction

S-adenosyl-L-methionine
+
a catechol
=
S-adenosyl-L-homocysteine
 +
a guaiacol

Synonyms

catechol methyltransferase, catechol-O-methyl transferase, catechol-O-methyl transferase, membrane bound, catechol-O-methyl transferase, soluble, catechol-O-methyltransferase, catechol-O-transferase, catecholamine O-methyltransferase, COMT, COMT I, COMT II, COMT-mb, COMT-s, COMT1, COMT2, CTOMT1, L-COMT, MB-COMT, methyltransferase, catechol, S-COMT, SCOMT

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.6 catechol O-methyltransferase

Substrates Products

Substrates Products on EC 2.1.1.6 - catechol O-methyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(+)-catechin + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
(+)-epicatechin + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
(-)-epicatechin + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
(-)-epigallocatechin + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
(-)-epigallocatechin-3-O-gallate + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
(R)-1,2-dihydroxy-4-[2-(methylamino)butyl]benzene + S-adenosyl-L-methionine
?
show the reaction diagram
-
-
-
-
?
(R)-3,4-dihydroxymethamphetamine + S-adenosyl-L-methionine
?
show the reaction diagram
-
-
-
-
?
(R)-N-ethyl-3,4-dihydroxyamphetamine + S-adenosyl-L-methionine
?
show the reaction diagram
-
-
-
-
?
(S)-1,2-dihydroxy-4-[2-(methylamino)butyl]benzene + S-adenosyl-L-methionine
?
show the reaction diagram
-
-
-
-
?
(S)-3,4-dihydroxymethamphetamine + S-adenosyl-L-methionine
?
show the reaction diagram
-
-
-
-
?
(S)-N-ethyl-3,4-dihydroxyamphetamine + S-adenosyl-L-methionine
?
show the reaction diagram
-
-
-
-
?
1-carboxy-1-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
1-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
2-hydroxyestradiol + S-adenosyl-L-methionine
2-hydroxyestradiol 3-methyl ether + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
-
?
2-hydroxyestradiol + S-adenosyl-L-methionine
2-methoxyestradiol + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
-
?
2-hydroxyestradiol + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + 2-methoxyestradiol + 2-hydroxy-3-methoxyestradiol
show the reaction diagram
-
-
-
-
?
2-hydroxyestradiol + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
2-hydroxyestradiol-17beta + S-adenosyl-L-methionine
2-methoxyestradiol-17beta + 2-hydroxyestradiol-17beta methyl ether + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
?
2-hydroxyestrogen + S-adenosyl-L-methionine
2-methoxyestrogen + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
-
?
2-hydroxyestrone + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
the production of 2-methoxyestrone in cultures treated with 2-hydroxyestrone is approximately 2fold that of 4-methoxyestrone in cultures treated with 4-hydroxyestrone
-
-
?
3,4-dihydroxybenzoic acid + S-adenosyl-L-methionine
3-hydroxy-4-methoxybenzoic acid + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
-
?
3,4-dihydroxybenzoic acid + S-adenosyl-L-methionine
4-hydroxy-3-methoxybenzoic acid + S-adenosyl-L-homocysteine
show the reaction diagram
3,4-dihydroxybenzoic acid + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
3,4-dihydroxymandelic acid + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
3,4-dihydroxyphenylacetic acid + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
3,5-dinitrocatechol + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
3-hydroxytyramine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + 3-methoxytyramine
show the reaction diagram
-
-
-
-
?
4-hydroxyestradiol + S-adenosyl-L-methionine
(17beta)-estra-1(10),2,4-triene-3,4,17-triol + S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
MCF-10F cells oxidize 4-hydroxyestradiol to estrone (estradiol)-3,4-quinones, which react with DNA to form the depurinating N3Ade and N7Gua adducts
-
-
?
4-hydroxyestradiol + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
-
?
4-hydroxyestradiol + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
4-hydroxyestrogen + S-adenosyl-L-methionine
4-methoxyestrogen + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
-
?
4-hydroxyestrone + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
4-nitrocatechol + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
6,7-dihydroxycoumarin + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
adrenaline + S-adenosyl-L-methionine
methanephrine + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
-
?
adrenaline + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
aesculetin + S-adenosyl-L-methionine
scopoletin + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
-
?
benzene-1,2-diol + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
show the reaction diagram
caffeic acid + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
catechol + S-adenosyl-L-methionine
guaiacol + S-adenosyl-L-homocysteine
show the reaction diagram
catechol + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
catecholestradiol + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
catecholestrone + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
DL-3,4-dihydroxyamphetamine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
DL-3,4-dihydroxyephedrine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
dobutamine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
dopa + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
dopamine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + 3-O-methyldopamine
show the reaction diagram
-
-
-
-
?
dopamine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
epinephrine + S-adenosyl-L-methionine
metanephrine + S-adenosyl-L-homocysteine
show the reaction diagram
epinine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
esculetin + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
-
?
esculetin + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
fisetin + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
homoprotocatechuic acid + S-adenosyl-L-methionine
?
show the reaction diagram
-
-
-
-
?
isoetharine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
isoproterenol + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
L-dopa + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
show the reaction diagram
L-dopa + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + 3-O-methyl-L-dopa
show the reaction diagram
L-Dopa + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + 3-O-methyldopa
show the reaction diagram
noradrenaline + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
norepinephrine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + normetanephrine
show the reaction diagram
p-nitrocatechol + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
procyanidin dimer B1 + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
procyanidin dimer B2 + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
procyanidin dimer B3 + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
procyanidin dimer B4 + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
procyanidin dimer B5 + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
procyanidin dimer B7 + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
procyanidin trimer C1 + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
protocatechualdehyde + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
protocatechuic acid + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
protocatechuic aldehyde + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
show the reaction diagram
-
17% of the activity with catechol
-
-
?
quercetin + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
S-adenosyl-L-homocysteine + 4''-O-methyl epigallocatechin gallate
S-adenosyl-L-homocysteine + 4',4''-di-O-methyl epigallocatechin gallate
show the reaction diagram
S-adenosyl-L-methionine + (3,4-dihydroxyphenyl)acetic acid
S-adenosyl-L-homocysteine + (4-hydroxy-3-methoxyphenyl)acetic acid + (3-hydroxy-4-methoxyphenyl)acetic acid
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 1,2-dihydroxyphenanthrene
S-adenosyl-L-homocysteine + 1-methoxy-2-hydroxyphenanthrene + 1-methoxy-2-hydroxyphenanthrene
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + 1-hydroxyestradiol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 1-hydroxypyrene
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + 2,3-dihydroxybenzaldehyde
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 2,3-dihydroxynaphthalene
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 2-(1-thienyl)ethyl-3,4-dihydroxybenzylcyano acetate
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 2-hydroxyestradiol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
S-adenosyl-L-methionine + 3,4-dihydroxy-L-Phe
S-adenosyl-L-homocysteine + ?
show the reaction diagram
S-adenosyl-L-methionine + 3,4-dihydroxyacetophenone
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 3,4-dihydroxybenzaldehyde
S-adenosyl-L-homocysteine + 4-hydroxy-3-methoxybenzaldehyde + 3-hydroxy-4-methoxybenzaldehyde
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 3,4-dihydroxybenzoic acid
S-adenosyl-L-homocysteine + 4-hydroxy-3-methoxybenzoic acid + 3-hydroxy-4-methoxybenzoic acid
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 3,4-dihydroxybenzoic acid
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + 3,4-dihydroxybenzoic acid ethyl ester
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 3,4-dihydroxymandelic acid
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 3,4-dihydroxyphenylacetic acid
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 3,4-dihydroxyphenylglycol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 3-fluorocatechol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 3-methoxy-5-bromocatechol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 3-methoxycatechol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 4-chlorocatechol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 4-hydroxyequilenin
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + 4-hydroxyestradiol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
S-adenosyl-L-methionine + 4-isopropylcatechol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 4-methylcatechol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 4-nitrobenzene-1,2-diol
S-adenosyl-L-homocysteine + 2-methoxy-4-nitrophenol + 2-methoxy-5-nitrophenol
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 4-nitrocatechol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 4-tert-butyl-5-methoxycatechol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 4-tert-butylcatechol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 5-hydroxydopamine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 6-hydroxydopa
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 6-hydroxydopamine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + a catechol
?
show the reaction diagram
S-adenosyl-L-methionine + a catechol
S-adenosyl-L-homocysteine + a guaiacol
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + adrenaline
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + anthrarobin
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + carbidopa
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + catechin
S-adenosyl-L-homocysteine + ?
show the reaction diagram
S-adenosyl-L-methionine + catechol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
S-adenosyl-L-methionine + catecholamine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + chlorogenic acid
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + dihydrexidine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + dobutamine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + dopamine
S-adenosyl-L-homocysteine + 3-methoxytyramine
show the reaction diagram
-
-
-
-
r
S-adenosyl-L-methionine + dopamine
S-adenosyl-L-homocysteine + 3-O-methyldopamine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + dopamine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
S-adenosyl-L-methionine + epicatechin
S-adenosyl-L-homocysteine + ?
show the reaction diagram
S-adenosyl-L-methionine + epicatechin gallate
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + epigallocatechin
S-adenosyl-L-homocysteine + ?
show the reaction diagram
S-adenosyl-L-methionine + epigallocatechin gallate
S-adenosyl-L-homocysteine + 4''-O-methyl epigallocatechin gallate
show the reaction diagram
S-adenosyl-L-methionine + epigallocatechin gallate
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + epigallocatechin-3-gallate
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + epinephrine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
S-adenosyl-L-methionine + epinephrine
S-adenosyl-L-homocysteine + metanephrine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + esculetin
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + esculetin
S-adenosyl-L-homocysteine + scopoletin
show the reaction diagram
S-adenosyl-L-methionine + ethyl-3,4-dihydroxybenzylcyanoacetate
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + fisetin
S-adenosyl-L-homocysteine + ?
show the reaction diagram
S-adenosyl-L-methionine + gallic acid
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + isoproterenol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + L-Dopa
S-adenosyl-L-homocysteine + ?
show the reaction diagram
S-adenosyl-L-methionine + levodopa
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + methyl gallate
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + noradrenaline
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + norepinephrine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
S-adenosyl-L-methionine + norepinephrine
S-adenosyl-L-homocysteine + normetanephrine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + pyrene
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + pyrogallol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + quercetin
S-adenosyl-L-homocysteine + ?
show the reaction diagram
S-adenosyl-L-methionine + R-salsolinol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + rosmarinic acid
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + salsoline
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + salsoline-1-carboxylic acid
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + scopoletin
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + SKF38393
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + tetrachlorocatechol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
salvianolic acid B + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
tolcapone + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + ?
show the reaction diagram
additional information
?
-