2.1.1.5: betaine-homocysteine S-methyltransferase
This is an abbreviated version!
For detailed information about betaine-homocysteine S-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.5
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2.1.1.5
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cystathionine
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s-adenosylmethionine
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choline
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folate
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remethylation
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hyperhomocysteinemia
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s-adenosylhomocysteine
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adenosyltransferase
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n-methyltransferase
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one-carbon
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beta-synthase
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dimethylglycine
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transsulfuration
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methylenetetrahydrofolate
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5-methyltetrahydrofolate-homocysteine
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transmethylation
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medicine
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mthfd1
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guanidinoacetate
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homocysteine-induced
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folate-dependent
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homocystinuria
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5-methyltetrahydrofolate
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transcobalamin
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b-vitamins
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slc19a1
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hypotaurine
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molecular biology
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analysis
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nutrition
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food industry
- 2.1.1.5
- cystathionine
- s-adenosylmethionine
- choline
- folate
-
remethylation
- hyperhomocysteinemia
- s-adenosylhomocysteine
-
adenosyltransferase
- n-methyltransferase
-
one-carbon
- beta-synthase
- dimethylglycine
-
transsulfuration
- methylenetetrahydrofolate
-
5-methyltetrahydrofolate-homocysteine
-
transmethylation
- medicine
- mthfd1
- guanidinoacetate
-
homocysteine-induced
-
folate-dependent
- homocystinuria
- 5-methyltetrahydrofolate
-
transcobalamin
-
b-vitamins
-
slc19a1
- hypotaurine
- molecular biology
- analysis
- nutrition
- food industry
Reaction
Synonyms
betaine homocysteine methyltransferase, betaine homocysteine methyltransferase-1, betaine homocysteine S-methyltransferase, betaine-homocysteine methyltransferase, betaine-homocysteine S-methyltransferase, betaine-homocysteine S-methyltransferase 2, betaine-homocysteine S-methyltransferase-2, betaine-homocysteine transmethylase, betaine:homocysteine methyltransferase, betaine:homocysteine S-methyltransferase, BHMT, BHMT-1, BHMT-2, BHMT1, BHMT2, methyltransferase, betaine-homocysteine
ECTree
2.1.1.5 betaine-homocysteine S-methyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.1.1.5 - betaine-homocysteine S-methyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-homocysteine + S-methylmethionine
?
-
BHMT-2 uses S-methylmethionine as a methyl donor for the methylation of homocysteine. Unlike BHMT, BHMT-2 can not use betaine
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-
?
additional information
?
-
-
BHMT can utilize S-methylmethionine as a substrate in vitro with a very low affinity
-
-
?
L-Asp + dimethylsulfonioacetate
?
-
using the non-physiological methyl donor dimethylsulfonioacetate an O-methylation of Asp is performed by BHMT, but only in the presence of beta-mercaptoethanol
-
-
?
L-homocysteine + betaine
L-methionine + dimethylglycine
-
-
-
-
?
L-homocysteine + betaine
L-methionine + dimethylglycine
-
-
-
-
?
L-homocysteine + betaine
L-methionine + dimethylglycine
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-
-
-
?
L-homocysteine + betaine
L-methionine + dimethylglycine
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reduced BHMT activity in cirrhotic livers may explain the elevated plasma homocysteine levels in cirrhosis
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-
?
L-homocysteine + betaine
L-methionine + dimethylglycine
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folate-independent remethylation of homocysteine
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-
?
L-homocysteine + betaine
L-methionine + dimethylglycine
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this reaction processes 25% of the cellular L-homocysteine in an in vitro model
-
-
?
L-homocysteine + betaine
L-methionine + dimethylglycine
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the enzyme can be modified by tissue-type transglutaminase and its activity is regulated repressively by the modification, especially by the cross-linking. This regulatory reaction might be involved in the regulation of homocysteine metabolism in the liver
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-
?
L-homocysteine + S-methyl-L-methionine
?
-
BHMT-2 uses S-methylmethionine as a methyl donor for the methylation of homocysteine. Unlike BHMT, BHMT-2 can not use betaine
-
-
?
N,N,N-trimethylglycine + L-homocysteine
N,N-dimethylglycine + L-methionine
-
-
-
?
N,N,N-trimethylglycine + L-homocysteine
N,N-dimethylglycine + L-methionine
-
-
-
?
N,N,N-trimethylglycine + L-homocysteine
N,N-dimethylglycine + L-methionine
-
-
-
?
N,N,N-trimethylglycine + L-homocysteine
N,N-dimethylglycine + L-methionine
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i.e. betaine, methyl transfer directly from one substrate to the other
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?
N,N,N-trimethylglycine + L-homocysteine
N,N-dimethylglycine + L-methionine
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enzyme cristallin in lens
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-
?
N,N,N-trimethylglycine + L-homocysteine
N,N-dimethylglycine + L-methionine
-
-
-
?
N,N,N-trimethylglycine + L-homocysteine
N,N-dimethylglycine + L-methionine
-
-
-
?
N,N,N-trimethylglycine + L-homocysteine
N,N-dimethylglycine + L-methionine
-
-
-
?
N,N,N-trimethylglycine + L-homocysteine
N,N-dimethylglycine + L-methionine
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i.e. betaine, involved in betaine metabolism
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-
?
N,N,N-trimethylglycine + L-homocysteine
N,N-dimethylglycine + L-methionine
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-
-
?
