2.1.1.5: betaine-homocysteine S-methyltransferase

This is an abbreviated version!
For detailed information about betaine-homocysteine S-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.5

2.1.1.5

cystathionine

s-adenosylmethionine

choline

folate

remethylation

hyperhomocysteinemia

s-adenosylhomocysteine

adenosyltransferase

n-methyltransferase

one-carbon

beta-synthase

dimethylglycine

transsulfuration

methylenetetrahydrofolate

5-methyltetrahydrofolate-homocysteine

transmethylation

medicine

mthfd1

guanidinoacetate

homocysteine-induced

folate-dependent

homocystinuria

5-methyltetrahydrofolate

transcobalamin

b-vitamins

slc19a1

hypotaurine

molecular biology

analysis

nutrition

food industry

Reaction

Synonyms

betaine homocysteine methyltransferase, betaine homocysteine methyltransferase-1, betaine homocysteine S-methyltransferase, betaine-homocysteine methyltransferase, betaine-homocysteine S-methyltransferase, betaine-homocysteine S-methyltransferase 2, betaine-homocysteine S-methyltransferase-2, betaine-homocysteine transmethylase, betaine:homocysteine methyltransferase, betaine:homocysteine S-methyltransferase, BHMT, BHMT-1, BHMT-2, BHMT1, BHMT2, methyltransferase, betaine-homocysteine

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.5 betaine-homocysteine S-methyltransferase

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Results	in table
28	Activating Compound
724	AA Sequence
25	Application
1	CAS Registry Number
10	Cloned(Commentary)
7	Crystallization (Commentary)
168	Disease/ Diagnostics
6	Expression
7	General Information
8	General Stability
14	IC50 Value
100	Inhibitors
4	kcat/KM [mM/s]
3	Ki Value [mM]
58	KM Value [mM]
12	Localization
11	Metals/Ions
14	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
311	Organism
1	Oxidation Stability
8	Pathway
16	PDB ID
10	pH Optimum
1	pH Stability
1	pI Value
1	Posttranslational Modification
60	Protein Variants
11	Purification (Commentary)
4	Reaction
1	Reaction Type
89	Reference
105	Source Tissue
13	Specific Activity [micromol/min/mg]
6	Storage Stability
50	Substrates and Products (Substrate)
12	Subunits
78	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
37	Turnover Number [1/s]

Metals Ions

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Metals Ions on EC 2.1.1.5 - betaine-homocysteine S-methyltransferase

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K+

Homo sapiens

Q93088

Km value around 0.1 mM. The presence of potassium ions lowers the apparent KM of the enzyme for homocysteine, but it does not affect the apparent KM for betaine or the apparent kcat for either substrate

735230

Zinc

Homo sapiens

Q93088

wild-type enzyme contains zinc. Mutant enzymes H338A, R346A, W352A, R361A, P362A, Y363A, N364A, P365A maintain normal or near-normal ability to bind zinc

657666

3 entries

Zn2+

5 entries