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2.1.1.5: betaine-homocysteine S-methyltransferase

This is an abbreviated version!
For detailed information about betaine-homocysteine S-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.5

Reaction

betaine
+
L-homocysteine
=
dimethylglycine
+
L-methionine

Synonyms

betaine homocysteine methyltransferase, betaine homocysteine methyltransferase-1, betaine homocysteine S-methyltransferase, betaine-homocysteine methyltransferase, betaine-homocysteine S-methyltransferase, betaine-homocysteine S-methyltransferase 2, betaine-homocysteine S-methyltransferase-2, betaine-homocysteine transmethylase, betaine:homocysteine methyltransferase, betaine:homocysteine S-methyltransferase, BHMT, BHMT-1, BHMT-2, BHMT1, BHMT2, methyltransferase, betaine-homocysteine

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.5 betaine-homocysteine S-methyltransferase

Expression

Expression on EC 2.1.1.5 - betaine-homocysteine S-methyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
corticosteroids down-regulate in kidney expression and activity
-
corticosteroids stimulate activity in the liver and also up-regulate the gene expression
-
decreased expression after exogenous addition of all-trans-retinoic acid
-
during fetal development, a total of ten splice variants of BHMT are expressed at varying levels across a wide range of porcine tissues. Two variants contain an identical ORF that encodes a C-terminal truncated form of BHMT
-
significant upregulation of betaine homocysteine methyltransferase-1 in livers of rats fed a betaine supplemented ethanol diet
-
the activity of hepatic BHMT significantly increases with increase in both dietary casein level and dietary methionine level, hepatic level of mRNA for BHMT is parallel to the enzyme activity
-