2.1.1.5: betaine-homocysteine S-methyltransferase
This is an abbreviated version!
For detailed information about betaine-homocysteine S-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.5
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2.1.1.5
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cystathionine
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s-adenosylmethionine
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choline
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folate
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remethylation
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hyperhomocysteinemia
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s-adenosylhomocysteine
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adenosyltransferase
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n-methyltransferase
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one-carbon
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beta-synthase
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dimethylglycine
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transsulfuration
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methylenetetrahydrofolate
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5-methyltetrahydrofolate-homocysteine
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transmethylation
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medicine
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mthfd1
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guanidinoacetate
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homocysteine-induced
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folate-dependent
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homocystinuria
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5-methyltetrahydrofolate
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transcobalamin
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b-vitamins
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slc19a1
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hypotaurine
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molecular biology
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analysis
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nutrition
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food industry
- 2.1.1.5
- cystathionine
- s-adenosylmethionine
- choline
- folate
-
remethylation
- hyperhomocysteinemia
- s-adenosylhomocysteine
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adenosyltransferase
- n-methyltransferase
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one-carbon
- beta-synthase
- dimethylglycine
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transsulfuration
- methylenetetrahydrofolate
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5-methyltetrahydrofolate-homocysteine
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transmethylation
- medicine
- mthfd1
- guanidinoacetate
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homocysteine-induced
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folate-dependent
- homocystinuria
- 5-methyltetrahydrofolate
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transcobalamin
-
b-vitamins
-
slc19a1
- hypotaurine
- molecular biology
- analysis
- nutrition
- food industry
Reaction
Synonyms
betaine homocysteine methyltransferase, betaine homocysteine methyltransferase-1, betaine homocysteine S-methyltransferase, betaine-homocysteine methyltransferase, betaine-homocysteine S-methyltransferase, betaine-homocysteine S-methyltransferase 2, betaine-homocysteine S-methyltransferase-2, betaine-homocysteine transmethylase, betaine:homocysteine methyltransferase, betaine:homocysteine S-methyltransferase, BHMT, BHMT-1, BHMT-2, BHMT1, BHMT2, methyltransferase, betaine-homocysteine
ECTree
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Activating Compound
Activating Compound on EC 2.1.1.5 - betaine-homocysteine S-methyltransferase
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beta-mercaptoethanol
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using a redox-inert methyl acceptor, it is shown that BHMT requires a thiol reducing agent for activity. Short-term exposure of BHMT to reducing agent-free buffer inactivates the enzyme without causing any loss of its catalytic zinc. Activity can be completely restored by the re-addition of a thiol reducing agent
Insulin
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is effective in counteracting the stimulation of BHMT activity and mRNA levels produced by triamcinolone in rat hepatoma H4IIE cells
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L-methionine
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independent of dietary choline, supplemental methionine increases hepatic BHMT activity by ca. 30%
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only slightly increased homocysteine remethylation in response to addition of betaine to diets containing 0.07 and 0.24% supplemental methionine
betaine
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together with methionine restriction induces hepatic BHMT 4fold compared with methionine restriction alone, BHMT mRNAlevel is also increased by 3fold by betaine supplementation of methionine-replete diets
choline
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liver BHMT activity is 1.3fold higher in rats fed the methionine deficient diet containing choline than in rats fed the methionine-adequate diet containing supplemental choline
choline
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elevations in the liver activity, whereas it has no effect in the renal enzyme
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increases in BHMT activity are only observed when 4-methylpyrazole is included in the treatment
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dietary methionine level does not significantly affect BHMT-dependent homocysteine remethylation or the relative proportion of homocysteine that is remethylated by BHMT, also choline appears to have little impact on BHMT-dependent remethylation
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additional information
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taurine, cysteic acid, cysteine sulfinate, sulfate, glycine, L-serine, L-threonine do not affect activity
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additional information
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after 24 h, Bhmt expression increases 1.53fold under hypoosmotic conditions, Bhmt enzymatic activity is altered under anisoosmotic conditions
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additional information
after 24 h, Bhmt expression increases 1.53fold under hypoosmotic conditions, Bhmt enzymatic activity is altered under anisoosmotic conditions
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additional information
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choline and methionine do not affect BHMT activity, mRNA expression and immunodetectable protein in the kidney
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additional information
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diet increases BHMT activity with small elevations in expression
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additional information
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triamcinolone increases the level and rate of BHMT mRNA synthesis in H4IIE cells
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