2.1.1.45: thymidylate synthase
This is an abbreviated version!
For detailed information about thymidylate synthase, go to the full flat file.
Word Map on EC 2.1.1.45
-
2.1.1.45
-
5-fluorouracil
-
thymidine
-
colorectal
-
dihydrofolate
-
antifolate
-
methotrexate
-
dihydropyrimidine
-
pyrimidine
-
fluoropyrimidine
-
phosphorylase
-
ribonucleotide
-
leucovorin
-
pemetrexed
-
resect
-
fdump
-
uracil
-
mthfr
-
casey
-
schedule
-
polyglutamates
-
non-small
-
cisplatin
-
folylpolyglutamate
-
deoxyuridine
-
oxaliplatin
-
5-fluoro-2'-deoxyuridine
-
antimetabolite
-
orotate
-
irinotecan
-
capecitabine
-
5-fu-based
-
ccrf-cem
-
folate-dependent
-
gemcitabine
-
folinic
-
formyltransferase
-
quinazoline
-
glycinamide
-
dttp
-
polyglutamylation
-
2'-deoxyuridine
-
tegafur
-
medicine
-
methotrexate-resistant
-
deoxycytidylate
-
cross-complementing
-
drug development
-
transformylase
-
5-fu-induced
-
dutpase
-
aminopterin
-
deoxythymidine
- 2.1.1.45
- 5-fluorouracil
- thymidine
- colorectal
- dihydrofolate
- antifolate
- methotrexate
- dihydropyrimidine
- pyrimidine
-
fluoropyrimidine
- phosphorylase
- ribonucleotide
- leucovorin
- pemetrexed
-
resect
- fdump
- uracil
- mthfr
-
casey
-
schedule
- polyglutamates
-
non-small
- cisplatin
- folylpolyglutamate
- deoxyuridine
- oxaliplatin
- 5-fluoro-2'-deoxyuridine
-
antimetabolite
- orotate
- irinotecan
- capecitabine
-
5-fu-based
-
ccrf-cem
-
folate-dependent
- gemcitabine
-
folinic
-
formyltransferase
- quinazoline
- glycinamide
- dttp
-
polyglutamylation
- 2'-deoxyuridine
-
tegafur
- medicine
-
methotrexate-resistant
- deoxycytidylate
-
cross-complementing
- drug development
-
transformylase
-
5-fu-induced
- dutpase
- aminopterin
- deoxythymidine
Reaction
Synonyms
BgDHFR-TS, bifunctional TS-DHFR, DFR-TS, DHFR-TS, DHFR–TS, dihydrofolate reductase-thymidylate synthase, dTMP synthase, HTS, human TS, LBRM_06_0830, methylenetetrahydrofolate:dUMP C-methyltransferase, More, Thy1, ThyA, thymidylate synthase, thymidylate synthase A, thymidylate synthase-dihydrofolate reductase, thymidylate synthetase, ThyX, TMP synthetase, TMPS, TS, TS-DHFR, TSase, TYMS, Y110A7A.4
ECTree
Advanced search results
Subunits
Subunits on EC 2.1.1.45 - thymidylate synthase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
dimer
homodimer
monomer
additional information
?
x * 58000, recombinant bifunctional enzyme DHFR-TS, SDS-PAGE
dimer
-
-
dimer
-
-
three-dimensional structures of Toxoplasma gondii enzyme TS-DHFR at 3.7 A and of a loop truncated TS-DHFR enzyme, removing several flexible surface loops in the DHFR domain, improving resolution to 2.2 A. The TS-DHFR homodimer includes a junctional region containing a linked crossover helix between the DHFR domains of the two adjacent monomers, a long linker connecting the TS and DHFR domains, and a DHFR domain that is positively charged, importance of this region not only in DHFR catalysis but also in modulating the distal TS activity suggests a role for TS-DHFR interdomain interactions. The interactions between the TS and the DHFR domains within the same monomer are comprised of both electrostatic and hydrophobic interactions that are predominately hydrophobic, these include hydrophobic contacts between F231, F319, and M297 as well as P242, I573, and V596
additional information
-
three-dimensional structures of Toxoplasma gondii enzyme TS-DHFR at 3.7 A and of a loop truncated TS-DHFR enzyme, removing several flexible surface loops in the DHFR domain, improving resolution to 2.2 A. The TS-DHFR homodimer includes a junctional region containing a linked crossover helix between the DHFR domains of the two adjacent monomers, a long linker connecting the TS and DHFR domains, and a DHFR domain that is positively charged, importance of this region not only in DHFR catalysis but also in modulating the distal TS activity suggests a role for TS-DHFR interdomain interactions. The interactions between the TS and the DHFR domains within the same monomer are comprised of both electrostatic and hydrophobic interactions that are predominately hydrophobic, these include hydrophobic contacts between F231, F319, and M297 as well as P242, I573, and V596
additional information
the bifunctional folate and pyrimidine-metabolising enzyme dihydrofolate reductase-thymidylate synthase dihydrofolate reductase-thymidylate synthase is expressed from a single gene as a homodimer comprising of an N-terminal DHFR domain fused via a linker peptide to a TS domain at the C-terminus
additional information
-
the bifunctional folate and pyrimidine-metabolising enzyme dihydrofolate reductase-thymidylate synthase dihydrofolate reductase-thymidylate synthase is expressed from a single gene as a homodimer comprising of an N-terminal DHFR domain fused via a linker peptide to a TS domain at the C-terminus
-