2.1.1.45: thymidylate synthase
This is an abbreviated version!
For detailed information about thymidylate synthase, go to the full flat file.
Word Map on EC 2.1.1.45
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2.1.1.45
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5-fluorouracil
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thymidine
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colorectal
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dihydrofolate
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antifolate
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methotrexate
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dihydropyrimidine
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pyrimidine
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fluoropyrimidine
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phosphorylase
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ribonucleotide
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leucovorin
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pemetrexed
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resect
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fdump
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uracil
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mthfr
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casey
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schedule
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polyglutamates
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non-small
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cisplatin
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folylpolyglutamate
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deoxyuridine
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oxaliplatin
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5-fluoro-2'-deoxyuridine
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antimetabolite
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orotate
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irinotecan
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capecitabine
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5-fu-based
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ccrf-cem
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folate-dependent
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gemcitabine
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folinic
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formyltransferase
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quinazoline
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glycinamide
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dttp
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polyglutamylation
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2'-deoxyuridine
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tegafur
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medicine
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methotrexate-resistant
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deoxycytidylate
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cross-complementing
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drug development
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transformylase
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5-fu-induced
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dutpase
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aminopterin
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deoxythymidine
- 2.1.1.45
- 5-fluorouracil
- thymidine
- colorectal
- dihydrofolate
- antifolate
- methotrexate
- dihydropyrimidine
- pyrimidine
-
fluoropyrimidine
- phosphorylase
- ribonucleotide
- leucovorin
- pemetrexed
-
resect
- fdump
- uracil
- mthfr
-
casey
-
schedule
- polyglutamates
-
non-small
- cisplatin
- folylpolyglutamate
- deoxyuridine
- oxaliplatin
- 5-fluoro-2'-deoxyuridine
-
antimetabolite
- orotate
- irinotecan
- capecitabine
-
5-fu-based
-
ccrf-cem
-
folate-dependent
- gemcitabine
-
folinic
-
formyltransferase
- quinazoline
- glycinamide
- dttp
-
polyglutamylation
- 2'-deoxyuridine
-
tegafur
- medicine
-
methotrexate-resistant
- deoxycytidylate
-
cross-complementing
- drug development
-
transformylase
-
5-fu-induced
- dutpase
- aminopterin
- deoxythymidine
Reaction
Synonyms
BgDHFR-TS, bifunctional TS-DHFR, DFR-TS, DHFR-TS, DHFR–TS, dihydrofolate reductase-thymidylate synthase, dTMP synthase, HTS, human TS, LBRM_06_0830, methylenetetrahydrofolate:dUMP C-methyltransferase, More, Thy1, ThyA, thymidylate synthase, thymidylate synthase A, thymidylate synthase-dihydrofolate reductase, thymidylate synthetase, ThyX, TMP synthetase, TMPS, TS, TS-DHFR, TSase, TYMS, Y110A7A.4
ECTree
2.1.1.45 thymidylate synthaseAdvanced search results
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results (Purification
Purification on EC 2.1.1.45 - thymidylate synthase
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PURIFICATION (Commentary) 
ORGANISM
UNIPROT
LITERATURE
after purification and precipitation with ammonium sulfate, wild-type and K48Q TS are frozen at -80°C
ammonium sulfate precipitation and Q-Sepharose column chromatography
Blue-Sepharose column chromatography and Q-Sepharose column chromatography
GST-GVE2 TS fusion protein is purified by glutathione-Sepharose beads
HiTrap Blue-Sepharose column chromatography and HiTrap Q column chromatography
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methotrexate-Sepharose column chromatography and anion exchange column chromatography
partially
purified from phage infected E. coli
recombinant enzyme
recombinant enzyme, expressed in E. coli
recombinant His-tagged enzyme from Escherichia coli strain M15(pREP4) by nickel affinity chromatography
recombinant protein
recombinant Trypanosoma brucei Tsf-DHFR-TS from Escherichia coli strain BL21 Star (DE3) by methotrexate affinity chromatography and gel filtration
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ammonium sulfate precipitation and Q-Sepharose column chromatography
methotrexate-Sepharose column chromatography and anion exchange column chromatography
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methotrexate-Sepharose column chromatography and anion exchange column chromatography
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recombinant His-tagged enzyme from Escherichia coli strain M15(pREP4) by nickel affinity chromatography
recombinant His-tagged enzyme from Escherichia coli strain M15(pREP4) by nickel affinity chromatography
recombinant His-tagged enzyme from Escherichia coli strain M15(pREP4) by nickel affinity chromatography
