2.1.1.45: thymidylate synthase
This is an abbreviated version!
For detailed information about thymidylate synthase, go to the full flat file.
Word Map on EC 2.1.1.45
-
2.1.1.45
-
5-fluorouracil
-
thymidine
-
colorectal
-
dihydrofolate
-
antifolate
-
methotrexate
-
dihydropyrimidine
-
pyrimidine
-
fluoropyrimidine
-
phosphorylase
-
ribonucleotide
-
leucovorin
-
pemetrexed
-
resect
-
fdump
-
uracil
-
mthfr
-
casey
-
schedule
-
polyglutamates
-
non-small
-
cisplatin
-
folylpolyglutamate
-
deoxyuridine
-
oxaliplatin
-
5-fluoro-2'-deoxyuridine
-
antimetabolite
-
orotate
-
irinotecan
-
capecitabine
-
5-fu-based
-
ccrf-cem
-
folate-dependent
-
gemcitabine
-
folinic
-
formyltransferase
-
quinazoline
-
glycinamide
-
dttp
-
polyglutamylation
-
2'-deoxyuridine
-
tegafur
-
medicine
-
methotrexate-resistant
-
deoxycytidylate
-
cross-complementing
-
drug development
-
transformylase
-
5-fu-induced
-
dutpase
-
aminopterin
-
deoxythymidine
- 2.1.1.45
- 5-fluorouracil
- thymidine
- colorectal
- dihydrofolate
- antifolate
- methotrexate
- dihydropyrimidine
- pyrimidine
-
fluoropyrimidine
- phosphorylase
- ribonucleotide
- leucovorin
- pemetrexed
-
resect
- fdump
- uracil
- mthfr
-
casey
-
schedule
- polyglutamates
-
non-small
- cisplatin
- folylpolyglutamate
- deoxyuridine
- oxaliplatin
- 5-fluoro-2'-deoxyuridine
-
antimetabolite
- orotate
- irinotecan
- capecitabine
-
5-fu-based
-
ccrf-cem
-
folate-dependent
- gemcitabine
-
folinic
-
formyltransferase
- quinazoline
- glycinamide
- dttp
-
polyglutamylation
- 2'-deoxyuridine
-
tegafur
- medicine
-
methotrexate-resistant
- deoxycytidylate
-
cross-complementing
- drug development
-
transformylase
-
5-fu-induced
- dutpase
- aminopterin
- deoxythymidine
Reaction
Synonyms
BgDHFR-TS, bifunctional TS-DHFR, DFR-TS, DHFR-TS, DHFR–TS, dihydrofolate reductase-thymidylate synthase, dTMP synthase, HTS, human TS, LBRM_06_0830, methylenetetrahydrofolate:dUMP C-methyltransferase, More, Thy1, ThyA, thymidylate synthase, thymidylate synthase A, thymidylate synthase-dihydrofolate reductase, thymidylate synthetase, ThyX, TMP synthetase, TMPS, TS, TS-DHFR, TSase, TYMS, Y110A7A.4
ECTree
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IC50 Value
IC50 Value on EC 2.1.1.45 - thymidylate synthase
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0.000054 - 0.00027
(2S)-2-[([4-[(2-amino-6-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)sulfanyl]phenyl]carbonyl)amino]pentanedioic acid
0.00015 - 0.00019
(S)-2-(5(((1,2-dihydro-3-methyl-1-oxobenzo[f]quinazolin-9 yl)methyl)amino)1-oxo-2-isoindolinyl)glutaric acid
0.0000046
1-(5-cyano-1,6-dihydro-6-oxo-4-p-tolylpyrimidin-2-yl)-4-phenylthiosemicarbazide
Homo sapiens
pH 7.4, 30°C
0.00197
2,4-dioxo-N-(2-(1-(m-tolyl)-1H-1,2,3-triazol-4-yl)phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-sulfonamide
Homo sapiens
pH 7.4, 30°C
0.009
2-(2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)-4-cyanophenyl)acetic acid
Cryptosporidium hominis
25°C, pH not specified in the publication
0.011
2-(2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)-4-methoxyphenyl)acetic acid
Cryptosporidium hominis
25°C, pH not specified in the publication
0.016
2-(2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)phenyl) acetic acid
Cryptosporidium hominis
25°C, pH not specified in the publication
0.000013
2-(2-(4-hydroxybenzylidene)hydrazinyl)-6-oxo-4-(p-tolyl)-1,6-dihydropyrimidine-5-carbonitrile
Homo sapiens
pH 7.4, 30°C
0.018
2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido) terephthalic acid
Cryptosporidium hominis
25°C, pH not specified in the publication
0.028
2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)-4-chloro benzoic acid
Cryptosporidium hominis
25°C, pH not specified in the publication
0.011
2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)-4-cyanobenzoic acid
Cryptosporidium hominis
25°C, pH not specified in the publication
0.00038
2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-L-glutamic acid
Cryptosporidium hominis
-
pH not specified in the publication, temperature not specified in the publication
0.0046 - 0.023
2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one
0.0011 - 0.0025
2-amino-5-[(2-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one
0.00011 - 0.0023
2-amino-5-[(3,4-dichlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one
0.00023 - 0.0023
2-amino-5-[(3,4-dichlorophenyl)thio]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one
0.00069 - 0.0016
2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]-pyrimidin-4(3H)-one
0.0012 - 0.0023
2-amino-5-[(3,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one
0.00038 - 0.0023
2-amino-5-[(3-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one
0.00039 - 0.0022
2-amino-5-[(4-bromophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one
0.00075 - 0.0025
2-amino-5-[(4-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one
0.0013 - 0.0029
2-amino-6-ethyl-5-[(4-fluorophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one
0.00022 - 0.0017
2-amino-6-ethyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one
0.00011 - 0.0012
2-amino-6-methyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one
0.0000081
2-chloro-N'-[5-methyl-4-(4-methylphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetohydrazide
Homo sapiens
pH 7.4, 30°C
0.0000044
2-hydrazinyl-1,6-dihydro-6-oxo-4-p-tolyl pyrimidine-5-carbonitrile
Homo sapiens
pH 7.4, 30°C
0.01
3-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)-4-(carboxymethyl)benzoic acid
Cryptosporidium hominis
25°C, pH not specified in the publication
0.0000047
4-chloro-N'-(5-cyano-1,6-dihydro-6-oxo-4-p-tolylpyrimidin-2-yl)benzohydrazide
Homo sapiens
pH 7.4, 30°C
0.0000037
N',N'-diacetyl-N-(5-cyano-1,6-dihydro-6-oxo-4-p-tolylpyrimidin-2-yl)acetohydrazide
Homo sapiens
pH 7.4, 30°C
0.0000042
N'-(5-cyano-1,6-dihydro-6-oxo-4-p-tolylpyrimidin-2-yl)-4-nitrobenzohydrazide
Homo sapiens
pH 7.4, 30°C
0.0000157
N'-(5-cyano-1,6-dihydro-6-oxo-4-p-tolylpyrimidin-2-yl)benzohydrazide
Homo sapiens
pH 7.4, 30°C
0.00087
N-(2-(1-(2-chlorophenyl)-1H-1,2,3-triazol-4-yl) phenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-sulfonamide
Homo sapiens
pH 7.4, 30°C
0.0006
N-(2-(1-(3-chlorophenyl)-1H-1,2,3-triazol-4-yl) phenyl)-2,4-dioxo-1, 2,3,4-tetrahydropyrimidine-5-sulfonamide
Homo sapiens
pH 7.4, 30°C
0.00013
N-(2-(1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl) phenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-sulfonamide
Homo sapiens
pH 7.4, 30°C
0.00128
N-(3-(1-(2-chlorophenyl)-1H-1,2,3-triazol-4-yl) phenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-sulfonamide
Homo sapiens
pH 7.4, 30°C
0.00056
N-(3-(1-(3-chlorophenyl)-1H-1,2,3-triazol-4-yl) phenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-sulfonamide
Homo sapiens
pH 7.4, 30°C
0.00045
N-(3-(1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl) phenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-sulfonamide
Homo sapiens
pH 7.4, 30°C
0.000046 - 0.00023
N-(4-((2-amino-6-methyl-4-oxo-3,4-dihydro-5H-pyrrolo(3,2-d)pyrimidin-5-yl)methyl)benzoyl)-L-glutamic acid
0.00004
N-(4-((2-amino-6-methyl-4-oxo-3,4-dihydrothieno(2,3-d)pyrimidin-5-yl)sulfanyl)benzoyl)-L-glutamic acid
Homo sapiens
potent inhibitor of human TS and of human DHFR, it is a novel dual TS-DHFR inhibitor, 330-fold more potent than pemetrexed
0.000054 - 0.00027
N-(4-((2-amino-6-methyl-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-5-yl)thio)benzoyl)-L-glutamic acid
0.00165
N-(4-(1-(2-chlorophenyl)-1H-1,2,3-triazol-4-yl) phenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-sulfonamide
Homo sapiens
pH 7.4, 30°C
0.00158
N-(4-(1-(3-chlorophenyl)-1H-1,2,3-triazol-4-yl) phenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-sulfonamide
Homo sapiens
pH 7.4, 30°C
0.00074
N-(4-(1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl) phenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-sulfonamide
Homo sapiens
pH 7.4, 30°C
0.047
N-(4-[[(2,4-diaminopteridin-6-yl)methyl](methyl)amino]benzoyl)glutamic acid
Homo sapiens
-
-
0.0049
N-([5-[2-(2,4-diaminoquinazolin-6-yl)ethyl]-2,3-dihydrothiophen-2-yl]carbonyl)-4-methylideneglutamic acid
Homo sapiens
-
-
0.0054 - 0.23
N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)thio]-benzoyl]-L-glutamic acid
0.000018 - 0.00009
N-[4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)thio]benzoyl]-L-glutamic acid
0.000046 - 0.00023
N-[4-[(2-amino-6-methyl-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)methyl]benzoyl]-L-glutamic acid
0.000036 - 0.00004
N-[4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl]-L-glutamic acid
0.0048
N-[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]-2-fluorobenzoyl]-4-methylideneglutamic acid
Homo sapiens
-
-
0.008
N-[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]-4-methylideneglutamic acid
Homo sapiens
-
-
additional information
N-[4-[2-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-4-methylideneglutamic acid
0.000054
(2S)-2-[([4-[(2-amino-6-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)sulfanyl]phenyl]carbonyl)amino]pentanedioic acid
Homo sapiens
-
-
0.00027
(2S)-2-[([4-[(2-amino-6-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)sulfanyl]phenyl]carbonyl)amino]pentanedioic acid
Escherichia coli
-
-
0.00015
(S)-2-(5(((1,2-dihydro-3-methyl-1-oxobenzo[f]quinazolin-9 yl)methyl)amino)1-oxo-2-isoindolinyl)glutaric acid
Penaeus vannamei
at 30°C
0.00019
(S)-2-(5(((1,2-dihydro-3-methyl-1-oxobenzo[f]quinazolin-9 yl)methyl)amino)1-oxo-2-isoindolinyl)glutaric acid
Shrimp white spot syndrome virus
at 30°C
0.0046
Homo sapiens
-
-
0.023
2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one
Escherichia coli
-
IC50 above 0.023 mM
0.023
2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one
Toxoplasma gondii
-
IC50 above 0.023 mM
0.0011
Homo sapiens
-
-
0.002
2-amino-5-[(2-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one
Escherichia coli
-
-
0.0025
2-amino-5-[(2-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one
Toxoplasma gondii
-
-
0.00011
Homo sapiens
-
0.0012
2-amino-5-[(3,4-dichlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one
Toxoplasma gondii
-
-
0.0023
2-amino-5-[(3,4-dichlorophenyl)sulfanyl]-6-methylthieno[2,3-d]pyrimidin-4(3H)-one
Escherichia coli
-
-
0.00023
Homo sapiens
-
-
0.001
2-amino-5-[(3,4-dichlorophenyl)thio]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one
Toxoplasma gondii
-
-
0.0023
2-amino-5-[(3,4-dichlorophenyl)thio]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one
Escherichia coli
-
-
0.00069
Homo sapiens
-
-
0.0012
2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]-pyrimidin-4(3H)-one
Escherichia coli
-
-
0.0016
2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]-pyrimidin-4(3H)-one
Toxoplasma gondii
-
-
0.0012
Homo sapiens
-
-
0.0018
2-amino-5-[(3,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one
Escherichia coli
-
-
0.0023
2-amino-5-[(3,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one
Toxoplasma gondii
-
-
0.00038
Homo sapiens
-
-
0.0018
2-amino-5-[(3-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one
Toxoplasma gondii
-
-
0.0023
2-amino-5-[(3-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one
Escherichia coli
-
-
0.00039
Homo sapiens
-
-
0.0022
2-amino-5-[(4-bromophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one
Escherichia coli
-
-
0.0022
2-amino-5-[(4-bromophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one
Toxoplasma gondii
-
-
0.00075
Homo sapiens
-
-
0.0022
2-amino-5-[(4-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one
Toxoplasma gondii
-
-
0.0025
2-amino-5-[(4-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one
Escherichia coli
-
-
0.0011
Toxoplasma gondii
-
-
0.0014
2-amino-6-ethyl-5-(2-naphthylthio)thieno[2,3-d]pyrimidin-4(3H)-one
Escherichia coli
-
-
0.0084
2-amino-6-ethyl-5-(phenylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one
Toxoplasma gondii
-
-
0.028
2-amino-6-ethyl-5-(phenylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one
Escherichia coli
-
-
0.00028
Homo sapiens
-
-
0.0017
2-amino-6-ethyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one
Toxoplasma gondii
-
-
0.002
2-amino-6-ethyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one
Escherichia coli
-
-
0.0013
Homo sapiens
-
-
0.0026
2-amino-6-ethyl-5-[(4-fluorophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one
Toxoplasma gondii
-
-
0.0029
2-amino-6-ethyl-5-[(4-fluorophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one
Escherichia coli
-
-
0.00022
Homo sapiens
-
-
0.001
2-amino-6-ethyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one
Toxoplasma gondii
-
-
0.0017
2-amino-6-ethyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one
Escherichia coli
-
-
0.00012
Homo sapiens
-
0.0012
2-amino-6-methyl-5-(2-naphthylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one
Toxoplasma gondii
-
-
0.0024
2-amino-6-methyl-5-(2-naphthylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one
Escherichia coli
-
-
0.00011
Homo sapiens
-
0.0012
2-amino-6-methyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one
Escherichia coli
-
-
0.0012
2-amino-6-methyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one
Toxoplasma gondii
-
-
0.063
Homo sapiens
mutant K47A, pH not specified in the publication, temperature not specified in the publication
0.068
CQLYQRSG
Homo sapiens
wild-type, pH not specified in the publication, temperature not specified in the publication
0.068
CQLYQRSG
Homo sapiens
mutant Y202A, pH not specified in the publication, temperature not specified in the publication
0.3
CQLYQRSG
Homo sapiens
mutant F59A, pH not specified in the publication, temperature not specified in the publication
0.3
CQLYQRSG
Homo sapiens
mutant L198A, pH not specified in the publication, temperature not specified in the publication
0.000000022
Mus musculus
-
FdUMP[10] strongly inhibited cell growth in both FM3A cell lines, with a much lower resistance factor than FUdR and FdUMP
0.075
Homo sapiens
mutant Y202A, pH not specified in the publication, temperature not specified in the publication
0.08
LCQFYVVN
Homo sapiens
mutant K47A, pH not specified in the publication, temperature not specified in the publication
0.088
LCQFYVVN
Homo sapiens
wild-type, pH not specified in the publication, temperature not specified in the publication
0.12
LCQFYVVN
Homo sapiens
mutant F59A, pH not specified in the publication, temperature not specified in the publication
0.188
LCQFYVVN
Homo sapiens
mutant L198A, pH not specified in the publication, temperature not specified in the publication
0.057
Homo sapiens
mutant K47A, pH not specified in the publication, temperature not specified in the publication
0.067
LSCQLYQR
Homo sapiens
mutant Y202A, pH not specified in the publication, temperature not specified in the publication
0.068
LSCQLYQR
Homo sapiens
wild-type, pH not specified in the publication, temperature not specified in the publication
0.075
LSCQLYQR
Homo sapiens
wild-type, pH not specified in the publication, temperature not specified in the publication
0.152
LSCQLYQR
Homo sapiens
mutant K47A, pH not specified in the publication, temperature not specified in the publication
0.3
LSCQLYQR
Homo sapiens
mutant F59A, pH not specified in the publication, temperature not specified in the publication
0.3
LSCQLYQR
Homo sapiens
mutant L198A, pH not specified in the publication, temperature not specified in the publication
0.3
LSCQLYQR
Homo sapiens
mutant Y202A, pH not specified in the publication, temperature not specified in the publication
0.5
LSCQLYQR
Homo sapiens
mutant L198A, pH not specified in the publication, temperature not specified in the publication
0.013
Enterococcus faecalis
pH not specified in the publication, temperature not specified in the publication
0.000046
N-(4-((2-amino-6-methyl-4-oxo-3,4-dihydro-5H-pyrrolo(3,2-d)pyrimidin-5-yl)methyl)benzoyl)-L-glutamic acid
Homo sapiens
-
potent dual inhibitor of human TS and human DHFR, 2-fold more potent than PDDF and 206-fold more potent than pemetrexed
0.000069
N-(4-((2-amino-6-methyl-4-oxo-3,4-dihydro-5H-pyrrolo(3,2-d)pyrimidin-5-yl)methyl)benzoyl)-L-glutamic acid
Escherichia coli
-
potent inhibitor of human TS
0.00023
N-(4-((2-amino-6-methyl-4-oxo-3,4-dihydro-5H-pyrrolo(3,2-d)pyrimidin-5-yl)methyl)benzoyl)-L-glutamic acid
Toxoplasma gondii
-
moderate inhibitor of human thymidylate synthase
0.000054
N-(4-((2-amino-6-methyl-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-5-yl)thio)benzoyl)-L-glutamic acid
Homo sapiens
-
potent inhibitor of human TS and moderate inhibitor of human DHFR
0.000054
N-(4-((2-amino-6-methyl-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-5-yl)thio)benzoyl)-L-glutamic acid
Homo sapiens
potent inhibitor of human TS and moderate inhibitor of human DHFR
0.00027
N-(4-((2-amino-6-methyl-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-5-yl)thio)benzoyl)-L-glutamic acid
Escherichia coli
-
moderate inhibitor of human TS
0.0054
Homo sapiens
-
at 30°C and pH 7.4
0.027
N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)thio]-benzoyl]-L-glutamic acid
Toxoplasma gondii
-
at 30°C and pH 7.4
0.23
N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)thio]-benzoyl]-L-glutamic acid
Escherichia coli
-
at 30°C and pH 7.4
0.000018
Escherichia coli
-
-
0.000054
N-[4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)thio]benzoyl]-L-glutamic acid
Homo sapiens
-
-
0.00009
N-[4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)thio]benzoyl]-L-glutamic acid
Toxoplasma gondii
-
-
0.000046
N-[4-[(2-amino-6-methyl-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)methyl]benzoyl]-L-glutamic acid
Homo sapiens
-
-
0.000069
N-[4-[(2-amino-6-methyl-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)methyl]benzoyl]-L-glutamic acid
Escherichia coli
-
-
0.00023
N-[4-[(2-amino-6-methyl-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)methyl]benzoyl]-L-glutamic acid
Escherichia coli
-
-
0.000036
N-[4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl]-L-glutamic acid
Toxoplasma gondii
-
-
0.00004
N-[4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl]-L-glutamic acid
Escherichia coli
-
-
0.00004
N-[4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl]-L-glutamic acid
Homo sapiens
-
-
0.00004
N-[4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl]-L-glutamic acid
Homo sapiens
-
0.056
Homo sapiens
mutant K47A, pH not specified in the publication, temperature not specified in the publication
0.071
QFYVVNSE
Homo sapiens
mutant Y202A, pH not specified in the publication, temperature not specified in the publication
0.081
QFYVVNSE
Homo sapiens
wild-type, pH not specified in the publication, temperature not specified in the publication
0.3
QFYVVNSE
Homo sapiens
mutant L198A, pH not specified in the publication, temperature not specified in the publication
0.03
Homo sapiens
mutant Y202A, pH not specified in the publication, temperature not specified in the publication
0.045
SELSCQLY
Homo sapiens
wild-type, pH not specified in the publication, temperature not specified in the publication
0.052
SELSCQLY
Homo sapiens
mutant K47A, pH not specified in the publication, temperature not specified in the publication
0.3
SELSCQLY
Homo sapiens
mutant F59A, pH not specified in the publication, temperature not specified in the publication
0.3
SELSCQLY
Homo sapiens
mutant L198A, pH not specified in the publication, temperature not specified in the publication
0.05
Homo sapiens
mutant Y202A, pH not specified in the publication, temperature not specified in the publication
0.053
VNSELSCQ
Homo sapiens
mutant K47A, pH not specified in the publication, temperature not specified in the publication
0.088
VNSELSCQ
Homo sapiens
wild-type, pH not specified in the publication, temperature not specified in the publication
0.3
VNSELSCQ
Homo sapiens
mutant F59A, pH not specified in the publication, temperature not specified in the publication
0.3
VNSELSCQ
Homo sapiens
mutant L198A, pH not specified in the publication, temperature not specified in the publication
0.057
Homo sapiens
mutant K47A, pH not specified in the publication, temperature not specified in the publication
0.062
YVVNSELS
Homo sapiens
wild-type, pH not specified in the publication, temperature not specified in the publication
0.075
YVVNSELS
Homo sapiens
mutant Y202A, pH not specified in the publication, temperature not specified in the publication
0.3
YVVNSELS
Homo sapiens
mutant F59A, pH not specified in the publication, temperature not specified in the publication
0.3
YVVNSELS
Homo sapiens
mutant L198A, pH not specified in the publication, temperature not specified in the publication
0.00144
Homo sapiens
-
wild type enzyme, in 50 mM Tris-HCl, pH 7.4, 1 mM EDTA, 0.2% 2-mercaptoethanol, at 22°C
0.034
ZD1694
Homo sapiens
-
mutant enzyme A191K, in 50 mM Tris-HCl, pH 7.4, 1 mM EDTA, 0.2% 2-mercaptoethanol, at 22°C
additional information
Homo sapiens
-
value above 0.05
additional information
N-[4-[2-(2,4-diaminopyrido[3,2-d]pyrimidin-6-yl)ethyl]benzoyl]-4-methylideneglutamic acid
Homo sapiens
-
value above 0.05
additional information
N-[4-[2-(2-amino-4-methylquinazolin-6-yl)ethyl]benzoyl]-4-methylideneglutamic acid
Homo sapiens
-
value above 0.05