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2.1.1.41: sterol 24-C-methyltransferase

This is an abbreviated version!
For detailed information about sterol 24-C-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.41

Reaction

S-adenosyl-L-methionine
+
5alpha-cholesta-8,24-dien-3beta-ol
=
S-adenosyl-L-homocysteine
 +
24-methylene-5alpha-cholest-8-en-3beta-ol

Synonyms

(S)-adenosyl-L-methionine:DELTA24(25)-sterol methyl transferase, 24-C-sterol methyltransferase, 24-SMT, 24-sterol C-methyltransferase, C-24 sterol methyltransferase, C24-methyltransferase, DELTA(24,25)-SMT, DELTA24-methyltransferase, DELTA24-sterol methyltransferase, Erg6, Erg6p, LMJF_36_2380, LMJF_36_2390, methyltransferase, DELTA24-sterol, PbSMT, phytosterol methyltransferase, S-adenosyl-4-methionine:sterol DELTA24-methyltransferase, S-adenosyl-L-methionine:DELTA24(23)-sterol methyltransferase, SAM:SMT, SMT, SMT protein, SMT1, SMT80, SMT90, sterol 24-C-methyltransferase, sterol C24-methyltransferase, sterol methyltransferase, STM, TbSMT, zymosterol 24-methyltransferase, zymosterol-24-methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.41 sterol 24-C-methyltransferase

Substrates Products

Substrates Products on EC 2.1.1.41 - sterol 24-C-methyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(3beta)-3-fluorolanost-8,24-diene + S-adenosyl-L-methionine
(3beta)-3-fluoro-24-methylidenelanost-8-ene + S-adenosyl-L-homocysteine
show the reaction diagram
-
catalytic competence: 16%
-
-
?
(3beta)-3-methoxylanosta-8,24-diene + S-adenosyl-L-methionine
(3beta)-3-methoxy-24-methylidenelanost-8-ene + S-adenosyl-L-homocysteine
show the reaction diagram
-
catalytic competence: 18%
-
-
?
(3beta)-lanosta-8,24-dien-3-amine + S-adenosyl-L-methionine
(3beta)-24-methylidenelanost-8-en-3-amine + S-adenosyl-L-homocysteine
show the reaction diagram
-
catalytic competence: 22%
-
-
?
(3beta)-lanosta-8,24-dien-3-yl acetate + S-adenosyl-L-methionine
(3beta)-24-methylidenelanost-8-en-3-yl acetate + S-adenosyl-L-homocysteine
show the reaction diagram
-
catalytic competence: 29%
-
-
?
14alpha-methylergosta-8,24(28)-diene + S-adenosyl-L-methionine
?
show the reaction diagram
-
-
-
-
?
14alpha-methylzymosterol + S-adenosyl-L-methionine
14alpha-methyl-24-methylenezymosterol + S-adenosyl-L-homocysteine
show the reaction diagram
24(28)-methylenecycloartanol + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
show the reaction diagram
-
ratio of DELTA25(27) to DELTA24(28)-product for wild-type is 100:0, 35% conversion
-
?
24(28)-methylenelophenol + S-adenosyl-L-methionine
?
show the reaction diagram
-
-
-
?
24-methylenecholesterol + S-adenosyl-L-methionine
24-ethylidenecholesterol + S-adenosyl-L-homocysteine
show the reaction diagram
-
5% the reaction rate of zymosterol
-
?
24-methylenelanosterol + S-adenosyl-L-methionine
pneumocysterol + S-adenosyl-L-homocysteine
show the reaction diagram
-
preferred substrate
-
?
26,27-dehydrozymosterol + S-adenosyl-L-methionine
26-homo-cholesta-8(9),23(24)E,26(26')-trienol + 26-homo-cholesta-8(9),26(26')-3beta,24beta-dienol + S-adenosyl-L-homocysteine
show the reaction diagram
-
mutants
-
?
26,27-dehydrozymosterol + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
show the reaction diagram
-
in contrast to the results with zymosterol, product analysis of the 26,27-dehydrozymosterol assays shows that multiple products are produced that occurred in different ratios determined by HPLC-radiocounting of the non-saponifiable lipid fractions. In these analyses two major product classes are identified, a neutral C26 sterol monol and a pair of C26-oxygenated diols
-
-
?
31-norlanosterol + S-adenosyl-L-methionine
?
show the reaction diagram
4alpha-methylzymosterol + S-adenosyl-L-methionine
?
show the reaction diagram
5-dehydroepisterol + S-adenosyl-L-methionine
?
show the reaction diagram
-
-
-
-
?
cholesta-5,7,24-triene + S-adenosyl-L-methionine
?
show the reaction diagram
-
-
-
-
?
cholesta-7,24-diene + S-adenosyl-L-methionine
?
show the reaction diagram
-
-
-
-
?
cholesterol + S-adenosyl-L-methionine
?
show the reaction diagram
-
-
-
-
?
cycloartenol + S-adenosyl-L-methionine
24(28)-methylenecycloartanol + S-adenosyl-L-homocysteine
show the reaction diagram
-
ratio of DELTA25(27) to DELTA24(28)-product for wild-type is 57:43, 70% conversion
-
?
cycloartenol + S-adenosyl-L-methionine
24-methylenecycloartanol + S-adenosyl-L-homocysteine
show the reaction diagram
dehydroergosterol + S-adenosyl-L-methionine
?
show the reaction diagram
-
-
-
-
?
desmosterol + S-adenosyl-L-methionine
24-methylenedesmosterol + S-adenosyl-L-homocysteine
show the reaction diagram
ergosta-5,8,22,24(28)-tetraene + S-adenosyl-L-methionine
?
show the reaction diagram
-
-
-
-
?
ergosterol + S-adenosyl-L-methionine
?
show the reaction diagram
-
-
-
-
?
lanosta-8,24-dien-3-one + S-adenosyl-L-methionine
24-methylidenelanost-8-en-3-one + S-adenosyl-L-homocysteine
show the reaction diagram
-
catalytic competence: 48%
-
-
?
lanosterol + S-adenosyl-L-methionine
24-methylene-24,25-dihydrolanosterol + S-adenosyl-L-homocysteine
show the reaction diagram
lanosterol + S-adenosyl-L-methionine
24beta-methyllanosta-8,25(27)-enol + 24(28)-methylenelanosterol + S-adenosyl-L-homocysteine
show the reaction diagram
-
products are 55% 24beta-methyllanosta-8,25(27)-enol, 38% 24(28)-methylenelanosterol (eburicol), and 7% 24beta-ethyllanosta-8,25(27)-enol
-
?
lanosterol-3beta-OH + S-adenosyl-L-methionine
24-methylene-24,25-dihydrolanosterol + S-adenosyl-L-homocysteine
show the reaction diagram
-
catalytic competence: 100%
-
-
?
obtusifoliol + S-adenosyl-L-methionine
? + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 24(28)-methylene cycloartenol
S-adenosyl-L-homocysteine + 24(28)-ethylidene cycloartenol
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 24(28)-methylene lophenol
S-adenosyl-L-homocysteine + 24(28)-ethylidene lophenol
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 26,27-dehydrolanosterol
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + 31-norlanosterol
?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + cycloartenol
S-adenosyl-L-homocysteine + 24-methylenecycloartanol
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + cycloartenol
S-adenosyl-L-homocysteine + cyclolaudenol + 24(28)-methylene cycloartanol
show the reaction diagram
reaction of EC 2.1.1.142
-
-
?
S-adenosyl-L-methionine + lanosterol
S-adenosyl-L-homocysteine + 24-methylene-24,25-dihydrolanosterol
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + lanosterol
S-adenosyl-L-homocysteine + 24beta-methyl lanosta-8,25(27)-enol + 24(28)-methylene lanosterol
show the reaction diagram
reaction of EC 2.1.1.142
-
-
?
S-adenosyl-L-methionine + obtusifoliol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + zymosterol
?
show the reaction diagram
-
GC-MS analysis of the enzyme-generated products from a soluble TbSMT shows the presence of four biomethylated sterols identified as ergosta-8,25(27)-dienol, ergosta-8,24(28)-dienol, ergosta-8,24(25)-dienol and 24-dimethyl ergosta-8,25(27)-dienol in a ratio of substrate/product of 7:3. The products distributed in a ratio of approximately 5:1:2:2 respectively
-
-
?
S-adenosyl-L-methionine + zymosterol
S-adenosyl-L-homocysteine + fecosterol
show the reaction diagram
zymosterol + S-adenosyl-L-methionine
24-methylzymosta-8,25(27)-dienol + S-adenosyl-L-homocysteine
show the reaction diagram
-
mutants D79L and E82L
-
?
zymosterol + S-adenosyl-L-methionine
?
show the reaction diagram
zymosterol + S-adenosyl-L-methionine
fecosterol + S-adenosyl-L-homocysteine
show the reaction diagram
additional information
?
-